PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19531467-12 2009 Our data demonstrate for the first time that PGN activates the nSMase/ceramide pathway to induce MKK3/6/p38 MAPK activation, which in turn initiates NF-kappaB activation and ultimately induces COX-2 expression in macrophages. Ceramides 70-78 mitogen-activated protein kinase kinase 3 Homo sapiens 97-103