PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22927247-3 2012 Applying liquid chromatography electrospray ionization tandem mass spectrometry, we revealed a significant decrease of proapoptotic ceramide in BCR/IL-4/CD40L-stimulated primary CLL cells compared with untreated controls. Ceramides 132-140 CD40 ligand Homo sapiens 153-158 16545138-8 2006 Co culture with CD40L L cells also blocked the apoptosis induced by exogenous ceramides in breast carcinoma and non Hodgkin"s lymphoma cell lines through a caspase-3-like, 8-like and 9-like dependent pathways. Ceramides 78-87 CD40 ligand Homo sapiens 16-21 16545138-9 2006 CONCLUSION: These results indicate that CD40L expressed on adjacent non tumoral cells induces multidrug resistance to cytotoxic agents and ceramides in both breast carcinoma and non Hodgkin"s lymphoma cell lines, albeit through a caspase independent and dependent pathway respectively. Ceramides 139-148 CD40 ligand Homo sapiens 40-45 9315737-2 1997 Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingomyelinase correlating with a consumption of sphingomyelin and a release of ceramide. Ceramides 204-212 CD40 ligand Homo sapiens 63-68 8976196-3 1996 Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-alpha and IL-1 beta, with intracellular ceramide accumulation, as they are induced to differentiate. Ceramides 141-149 CD40 ligand Homo sapiens 52-63