PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15474071-10 2004 CONCLUSION(S): The results suggest that IL-1alpha stimulates the production of IL-8 and M-CSF by a mechanism that involves the sphingomyelin-ceramide system. Ceramides 141-149 interleukin 1 alpha Homo sapiens 40-49 18751914-5 2008 TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders. Ceramides 83-91 interleukin 1 alpha Homo sapiens 14-18 17981627-4 2008 Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury. Ceramides 171-179 interleukin 1 alpha Homo sapiens 71-80 17404114-5 2007 RESULTS: We showed by DNA-binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1, and H(2)O(2) was suppressed by morin; the suppression was not cell type specific. Ceramides 159-167 interleukin 1 alpha Homo sapiens 169-182 15474071-1 2004 OBJECTIVE: To measure the level of interleukin 6 (IL-6), IL-8, and macrophage colony-stimulating factor (M-CSF) induced by IL-1alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues. Ceramides 193-201 interleukin 1 alpha Homo sapiens 123-132 11775008-2 2001 Our objective was to evaluate interleukin (IL)-1alpha-induced production of PGE2 and PGF2alpha in endometrial stromal cells (ESC) following treatment with ceramide analogues. Ceramides 155-163 interleukin 1 alpha Homo sapiens 30-53 11775008-13 2001 CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium. Ceramides 145-153 interleukin 1 alpha Homo sapiens 40-49 11775008-13 2001 CONCLUSIONS: These results suggest that IL-1alpha stimulates the production of PGE2 and PGF2alpha by a mechanism that involves the sphingomyelin-ceramide system, and thus that ceramide may be important in increasing the production of PGE2 and PGF2alpha in the human endometrium. Ceramides 176-184 interleukin 1 alpha Homo sapiens 40-49 9736250-0 1998 Identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells. Ceramides 18-26 interleukin 1 alpha Homo sapiens 38-83 11167182-11 2001 CONCLUSIONS: Results suggest that IL-1alpha induce the PGHS-2 mRNA and stimulate the production of PGE2 by a mechanism that involves the sphingomyelin-ceramide system. Ceramides 151-159 interleukin 1 alpha Homo sapiens 34-43 11717138-0 2001 Interleukin 1 upregulates ovarian prostaglandin endoperoxide synthase-2 expression: evidence for prostaglandin-dependent/ceramide-independent transcriptional stimulation and for message stabilization. Ceramides 121-129 interleukin 1 alpha Homo sapiens 0-13 11167182-0 2001 Effect of ceramide analogs on interleukin-1alpha-induced production of prostaglandin E2 by amnion-derived (WISH) cells. Ceramides 10-18 interleukin 1 alpha Homo sapiens 30-48 11167182-2 2001 Our objective was to measure the level of PGE2 induced by interleukin (IL)-1alpha following treatment with ceramide analogs in amnion-derived cells. Ceramides 107-115 interleukin 1 alpha Homo sapiens 58-81 10390188-3 1999 Ceramide, a product of sphingomyelin hydrolysis, is a known mediator of apoptotic effects of TNF, IL-1, and gammaIFN. Ceramides 0-8 interleukin 1 alpha Homo sapiens 98-102 7964160-0 1994 The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. Ceramides 31-39 interleukin 1 alpha Homo sapiens 69-82 9797556-0 1998 Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha, as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells. Ceramides 0-8 interleukin 1 alpha Homo sapiens 24-67 10200497-4 1998 IL-1 increases beta-cell formation of NO, ceramide, prostaglandins, heat-shock proteins, and activates a protease. Ceramides 42-50 interleukin 1 alpha Homo sapiens 0-4 7527398-4 1994 Ceramide has been proposed as an intracellular mediator of IL-1 action, but C2-ceramide or sphingosine stimulated predominantly MBP-specific kinase activity in fibroblasts and had no effect in HepG2 cells. Ceramides 0-8 interleukin 1 alpha Homo sapiens 59-63 8692926-1 1996 Interleukin 1 is the prototype of an inflammatory cytokine, and evidence suggests that it uses the sphingomyelin pathway and ceramide production to trigger mitogen-activated protein kinase (MAPK) activation and subsequent gene expression required for acute inflammatory processes. Ceramides 125-133 interleukin 1 alpha Homo sapiens 0-13 7544978-1 1995 Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Ceramides 130-138 interleukin 1 alpha Homo sapiens 61-80 7964160-3 1994 Two lipid second messengers have been found to transmit TNF and IL-1 intracellular signals: 1,2-diacylglycerol (DAG), generated by a phosphatidylcholine-specific phospholipase C, and ceramide, generated by sphingomyelinase (SMase). Ceramides 183-191 interleukin 1 alpha Homo sapiens 64-68 7964161-6 1994 In the past three years, several groups reported that IL-1 and tumor necrosis factor (TNF) rapidly induce sphingomyelin turnover in various types of cells, producing ceramide, which may act as a second messenger molecule in an intracellular signaling cascade. Ceramides 166-174 interleukin 1 alpha Homo sapiens 54-58 8034680-3 1994 Tumor necrosis factor alpha (TNF alpha) and interleukin-1, besides activating the phospholipase C-mediated breakdown of phosphatidylcholine, also generate ceramide, which is produced by stimulation of sphingomyelin hydrolysis. Ceramides 155-163 interleukin 1 alpha Homo sapiens 44-57 8376361-2 1993 Signal transduction for tumor necrosis factor-alpha and interleukin-1 involves sphingomyelin hydrolysis to ceramide and stimulation of a ceramide-activated serine/threonine protein kinase (Mathias, S., Younes, A., Kan, C., Orlow, I., Joseph, C., and Kolesnick, R. (1993) Science 259, 519-522). Ceramides 107-115 interleukin 1 alpha Homo sapiens 56-69 27313060-1 2016 The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Ceramides 39-47 interleukin 1 alpha Homo sapiens 166-170 27313060-1 2016 The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Ceramides 133-141 interleukin 1 alpha Homo sapiens 166-170 27313060-2 2016 Although much has been learned about ceramide generation by activation of sphingomyelinases in response to IL-1, the contribution of the de novo pathway is not completely understood. Ceramides 37-45 interleukin 1 alpha Homo sapiens 107-111 27313060-5 2016 IL-1 and the IL-6 family cytokine, oncostatin M, increased dihydroceramide and ceramide levels in HepG2 cells and concomitantly decreased ORMDL proteins. Ceramides 66-74 interleukin 1 alpha Homo sapiens 0-4 27313060-7 2016 Together, our results suggest that ORMDLs may be involved in regulation of ceramides during IL-1-mediated sterile inflammation. Ceramides 75-84 interleukin 1 alpha Homo sapiens 92-96 22451348-6 2012 Using this model, we assessed the effects of the inflammatory cytokine interleukin-1alpha (IL-1alpha), several bioactive sphingolipids and all-trans retinoic acid (RA) on ceramide levels in the SC. Ceramides 171-179 interleukin 1 alpha Homo sapiens 91-100 22451348-7 2012 Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels. Ceramides 73-81 interleukin 1 alpha Homo sapiens 23-32 22451348-7 2012 Whereas treatment with IL-1alpha (at 10 nM) significantly down-regulated ceramide levels, treatment with sphingosylphosphorylcholine (at 50 microM) or sphingosine-1-phosphate (at 10 or 20 microM) distinctly up-regulated ceramide levels. Ceramides 220-228 interleukin 1 alpha Homo sapiens 23-32 20540705-4 2010 Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFalpha, TRAIL, Fas ligand), cytokines (IL-1, IFNgamma), radiation, pathogenic infections, cytotoxic agents and others. Ceramides 25-33 interleukin 1 alpha Homo sapiens 217-221 32481596-6 2020 Cellular ceramide was elevated 2.67 +- 1.07-fold in RPE cells derived from diabetic donors compared to control donors, and these changes correlated with increased gene expression of IL-1beta, IL-6, and ASM. Ceramides 9-17 interleukin 1 alpha Homo sapiens 182-190