PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10919278-4 2000 Compared with TNF-alpha-induced JNK activation, ceramide elicits a more rapid activation of JNK within 30 min. Ceramides 48-56 mitogen-activated protein kinase 8 Homo sapiens 92-95 10903735-2 2000 It has been reported that cross-linking Abs to Fas trigger c-Jun N-terminal kinase (JNK) signaling via caspase-mediated activation of MEKK1 (JNK kinase kinase), elevation of ceramide levels or by recruitment of death domain associated protein (DAXX) to Fas. Ceramides 174-182 mitogen-activated protein kinase 8 Homo sapiens 84-87 10788436-2 2000 Both ceramide and TNF activate a wide variety of cellular responses, including NF-kappaB, AP-1, JNK, and apoptosis. Ceramides 5-13 mitogen-activated protein kinase 8 Homo sapiens 96-99 10788436-8 2000 Similarly, ceramide activated the protein kinases JNK and mitogen-activated protein kinase kinase in Jurkat cells but not in JCaM1 cells. Ceramides 11-19 mitogen-activated protein kinase 8 Homo sapiens 50-53 10666416-8 2000 Treatment of cardiac myocytes with extracellular ceramides also activated JNK. Ceramides 49-58 mitogen-activated protein kinase 8 Homo sapiens 74-77 10666416-12 2000 The results are consistent with a pathway of ceramide-mediated activation of JNK. Ceramides 45-53 mitogen-activated protein kinase 8 Homo sapiens 77-80 10340476-6 1999 Similarly, the ceramide-induced c-jun amino-terminal kinase (JNK/SAPK) activation is impaired in cells overexpressing Hsp70. Ceramides 15-23 mitogen-activated protein kinase 8 Homo sapiens 61-69 10531389-4 1999 Treatment of U937 cells with cell-permeant ceramides induced both an increase in ROS generation and JNK activation, and apoptosis, all of which were antioxidant-sensitive. Ceramides 43-52 mitogen-activated protein kinase 8 Homo sapiens 100-103 10531389-5 1999 In conclusion, DNR-triggered apoptosis implicates a ceramide-mediated, ROS-dependent JNK and activated protein-1 activation. Ceramides 52-60 mitogen-activated protein kinase 8 Homo sapiens 85-88 9478967-7 1998 These results show that triggering the ceramide signaling pathway activates MMP-1 gene expression via three distinct MAPK pathways, i.e. ERK1/2, SAPK/JNK, and p38, and suggest that targeted modulation of the ceramide signaling pathway may offer a novel therapeutic approach for inhibiting collagenolytic activity, e.g. in inflammatory disorders. Ceramides 39-47 mitogen-activated protein kinase 8 Homo sapiens 150-153 9830045-8 1998 Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase. Ceramides 18-26 mitogen-activated protein kinase 8 Homo sapiens 105-128 9830045-8 1998 Triggering of the ceramide pathway also led to increases in extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activities; pharmacological inhibitors of MAPK kinase (MEK) and p38 MAPK blocked the induction of COX-2 by SMase. Ceramides 18-26 mitogen-activated protein kinase 8 Homo sapiens 130-133 9884018-6 1998 Recent investigations link ceramide and its analogues to the extracellular signal-regulated kinase (ERK) cascade, stress-activated protein kinase-c-Jun kinase (SAPK/JNK) cascade and apoptotic responses. Ceramides 27-35 mitogen-activated protein kinase 8 Homo sapiens 165-168 9786905-7 1998 We also demonstrated that JNK activation does not require ceramide generation since in MCF7 cells transfected with a dominant-negative derivative of FADD (FADD-DN), which are resistant to the cytotoxic action of TNF, TNF induced JNK activation in the absence of ceramide generation. Ceramides 262-270 mitogen-activated protein kinase 8 Homo sapiens 26-29 9415703-3 1997 Ceramide robustly stimulated p46-JNK1/p54-JNK2 activity and increased expression of c-jun mRNA and c-Jun protein; in contrast, sphingosine moderately stimulated p46-JNK1/p54-JNK2 and failed to modify c-jun/c-Jun expression. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 33-37 9762361-2 1998 In the current study we extend those observations and examine the ability of both TNF and ceramide to activate the stress/cytokine activated p38 MAPK, the JNK and JAK-STAT pathways. Ceramides 90-98 mitogen-activated protein kinase 8 Homo sapiens 155-158 9354428-1 1997 The activation of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and/or extracellular signal-regulated kinase (ERK) is involved in ceramide-induced apoptosis in certain cells. Ceramides 155-163 mitogen-activated protein kinase 8 Homo sapiens 45-48 9354428-3 1997 In HKe-3 and HKh-2, the activity of JNK/SAPK increased significantly within 60 min following C2 ceramide stimulation, and some apoptosis followed. Ceramides 96-104 mitogen-activated protein kinase 8 Homo sapiens 36-44 9260915-2 1997 Moreover, ectopic expression of bcl-2 can impair apoptosis signaling by most of the cell stresses that activate the ceramide/JNK pathway. Ceramides 116-124 mitogen-activated protein kinase 8 Homo sapiens 125-128 9268362-0 1997 Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. Ceramides 8-16 mitogen-activated protein kinase 8 Homo sapiens 81-102 9268362-3 1997 The critical function of this signaling cascade is indicated by prevention of Fas- or C6-ceramide-induced apoptosis after inhibition of Ras, Rac1, or JNK/p38-K. Ceramides 89-97 mitogen-activated protein kinase 8 Homo sapiens 150-153 9260915-4 1997 Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. Ceramides 63-71 mitogen-activated protein kinase 8 Homo sapiens 84-88 9260915-4 1997 Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. Ceramides 63-71 mitogen-activated protein kinase 8 Homo sapiens 133-137 9260915-4 1997 Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. Ceramides 63-71 mitogen-activated protein kinase 8 Homo sapiens 133-137 9260915-4 1997 Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. Ceramides 63-71 mitogen-activated protein kinase 8 Homo sapiens 84-87 8645177-9 1996 Therefore, in blocking ceramide-stimulated ERK-2 activity, cyclic AMP may allow the ceramide-dependent activation of JNK to programme cells to opt out of the cell cycle. Ceramides 23-31 mitogen-activated protein kinase 8 Homo sapiens 117-120 9374036-4 1997 In several cell systems ceramide links to the stress-activated protein kinase (SAPK)/c-jun kinase (JNK) cascade to signal apoptosis. Ceramides 24-32 mitogen-activated protein kinase 8 Homo sapiens 99-102 8831497-7 1996 Extracellular SMase does not have access to intracellular sphingomyelin, but treatment of ECs with membrane-permeant ceramide analogues still completely fails to activate NF-kappa B and only activates JNK at late times. Ceramides 117-125 mitogen-activated protein kinase 8 Homo sapiens 201-204 8892112-9 1996 Incubation of cells with bacterial sphingomyelinase and a cell-permeable ceramide stimulated JNK activity, suggesting that the ceramide pathway may play a role in JNK activation, although the time course of activation did not correspond to that of TNF-alpha. Ceramides 73-81 mitogen-activated protein kinase 8 Homo sapiens 93-96 8892112-9 1996 Incubation of cells with bacterial sphingomyelinase and a cell-permeable ceramide stimulated JNK activity, suggesting that the ceramide pathway may play a role in JNK activation, although the time course of activation did not correspond to that of TNF-alpha. Ceramides 73-81 mitogen-activated protein kinase 8 Homo sapiens 163-166 8892112-9 1996 Incubation of cells with bacterial sphingomyelinase and a cell-permeable ceramide stimulated JNK activity, suggesting that the ceramide pathway may play a role in JNK activation, although the time course of activation did not correspond to that of TNF-alpha. Ceramides 127-135 mitogen-activated protein kinase 8 Homo sapiens 93-96 8892112-9 1996 Incubation of cells with bacterial sphingomyelinase and a cell-permeable ceramide stimulated JNK activity, suggesting that the ceramide pathway may play a role in JNK activation, although the time course of activation did not correspond to that of TNF-alpha. Ceramides 127-135 mitogen-activated protein kinase 8 Homo sapiens 163-166 8657285-5 1996 Finally sphingosine-1-phosphate not only stimulates the extracellular signal-regulated kinase (ERK) pathway, it counteracts the ceramide-induced activation of stress-activated protein kinase (SAPK/JNK). Ceramides 128-136 mitogen-activated protein kinase 8 Homo sapiens 197-200 9079627-2 1997 It has recently been reported that ceramide activates stress-activated protein kinase (SAPK, also known as c-Jun NH2-terminal kinase JNK), a subfamily member of mitogen-activated protein kinase superfamily molecules and that the ceramide/SAPK/JNK signaling pathway is required for stress-induced apoptosis. Ceramides 35-43 mitogen-activated protein kinase 8 Homo sapiens 133-136 9079627-2 1997 It has recently been reported that ceramide activates stress-activated protein kinase (SAPK, also known as c-Jun NH2-terminal kinase JNK), a subfamily member of mitogen-activated protein kinase superfamily molecules and that the ceramide/SAPK/JNK signaling pathway is required for stress-induced apoptosis. Ceramides 35-43 mitogen-activated protein kinase 8 Homo sapiens 243-246 9079627-2 1997 It has recently been reported that ceramide activates stress-activated protein kinase (SAPK, also known as c-Jun NH2-terminal kinase JNK), a subfamily member of mitogen-activated protein kinase superfamily molecules and that the ceramide/SAPK/JNK signaling pathway is required for stress-induced apoptosis. Ceramides 229-237 mitogen-activated protein kinase 8 Homo sapiens 133-136 9079627-2 1997 It has recently been reported that ceramide activates stress-activated protein kinase (SAPK, also known as c-Jun NH2-terminal kinase JNK), a subfamily member of mitogen-activated protein kinase superfamily molecules and that the ceramide/SAPK/JNK signaling pathway is required for stress-induced apoptosis. Ceramides 229-237 mitogen-activated protein kinase 8 Homo sapiens 243-246 9079627-3 1997 However, the molecular mechanism by which ceramide induces SAPK/JNK activation is unknown. Ceramides 42-50 mitogen-activated protein kinase 8 Homo sapiens 64-67 9079627-7 1997 Furthermore, expression of a kinase-negative form of TAK1 interfered with the activation of SAPK/JNK induced by ceramide. Ceramides 112-120 mitogen-activated protein kinase 8 Homo sapiens 97-100 9079627-8 1997 These results indicate that TAK1 may function as a mediator of ceramide signaling to SAPK/JNK activation. Ceramides 63-71 mitogen-activated protein kinase 8 Homo sapiens 90-93 8647130-6 1996 In contrast, sphingosine and cell-permeable ceramides elicit the prominent tyrosyl phosphorylation and activation of JNK, are poor stimulators of ERK-2, and do not induce the phosphorylation of p70(56K). Ceramides 44-53 mitogen-activated protein kinase 8 Homo sapiens 117-120 8647130-9 1996 For instance, both ceramide and sphingosine will elicit growth arrest via activation of JNK, whereas sphingosine phosphate will potentiate growth-factor-stimulated DNA synthesis, a consequence of the activation of ERK-2, Furthermore, under certain conditions, sphingosine and ceramide stimulate cAMP formation, a negative modulator of cell growth, whereas sphingosine phosphate depresses cAMP, thereby enhancing its own growth-promoting properties. Ceramides 19-27 mitogen-activated protein kinase 8 Homo sapiens 88-91 8645177-9 1996 Therefore, in blocking ceramide-stimulated ERK-2 activity, cyclic AMP may allow the ceramide-dependent activation of JNK to programme cells to opt out of the cell cycle. Ceramides 84-92 mitogen-activated protein kinase 8 Homo sapiens 117-120 28733206-8 2017 The increases in ceramide concentrations may induce ER stress and activate the JNK pathway by affecting the expression of the related genes, and eventually trigger the mitochondria-independent apoptosis in hepatocytes. Ceramides 17-25 mitogen-activated protein kinase 8 Homo sapiens 79-82 26698173-9 2016 Finally, we show that JNK mediates ceramide-activated PKR inhibitory action on IRS1. Ceramides 35-43 mitogen-activated protein kinase 8 Homo sapiens 22-25 28683288-4 2017 The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Ceramides 174-182 mitogen-activated protein kinase 8 Homo sapiens 274-297 28683288-4 2017 The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Ceramides 174-182 mitogen-activated protein kinase 8 Homo sapiens 299-302 26807955-9 2016 HepG2 cells treated with ceramide displayed increased phosphorylation of STAT3, JNK, and NF-kappaB proteins. Ceramides 25-33 mitogen-activated protein kinase 8 Homo sapiens 80-83 25576381-1 2015 Here we reported that co-administration of docetaxel and a cell-permeable short-chain ceramide (C6) resulted in a striking increase in growth inhibition and apoptosis in primary and transformed breast cells (MCF-7 and MDA-231), which were associated with mitochondrial permeability transition pore (mPTP) opening, a significant reactive oxygen species (ROS) production and the pro-apoptotic AMP-Protein Kinase (AMPK) as well as c-Jun N-terminal kinases (JNK) activations. Ceramides 86-94 mitogen-activated protein kinase 8 Homo sapiens 428-452 25576381-1 2015 Here we reported that co-administration of docetaxel and a cell-permeable short-chain ceramide (C6) resulted in a striking increase in growth inhibition and apoptosis in primary and transformed breast cells (MCF-7 and MDA-231), which were associated with mitochondrial permeability transition pore (mPTP) opening, a significant reactive oxygen species (ROS) production and the pro-apoptotic AMP-Protein Kinase (AMPK) as well as c-Jun N-terminal kinases (JNK) activations. Ceramides 86-94 mitogen-activated protein kinase 8 Homo sapiens 454-457 23543151-2 2013 Effect of ceramide on expression of mitochondrial Bax and phosphorylated (p)-ERK, p38MAPK and JNK, that of MAPKs inhibition, and of EGF in the presence or absence of MAPKs inhibition on ceramide-induced apoptosis were examined in HK-2 cells. Ceramides 10-18 mitogen-activated protein kinase 8 Homo sapiens 94-97 25168245-8 2015 In addition, the depletion of MAPK8/9 or SMPD2 by RNAi knockdown decreased ceramide generation and stress- and cytokine-induced apoptosis in Jurkat cells. Ceramides 75-83 mitogen-activated protein kinase 8 Homo sapiens 30-37 25168245-9 2015 Therefore the phosphorylation of nSMase1 is a pivotal step in JNK signaling, which leads to ceramide generation and apoptosis under stress conditions and in response to cytokine stimulation. Ceramides 92-100 mitogen-activated protein kinase 8 Homo sapiens 62-65 25168245-0 2015 Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. Ceramides 15-23 mitogen-activated protein kinase 8 Homo sapiens 102-105 25168245-3 2015 Here we show that the phosphorylation of nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2) by c-Jun N-terminal kinase (JNK) signaling stimulates ceramide generation and apoptosis and provide evidence for a signaling mechanism that integrates stress- and cytokine-activated apoptosis in vertebrate cells. Ceramides 146-154 mitogen-activated protein kinase 8 Homo sapiens 95-118 25168245-3 2015 Here we show that the phosphorylation of nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2) by c-Jun N-terminal kinase (JNK) signaling stimulates ceramide generation and apoptosis and provide evidence for a signaling mechanism that integrates stress- and cytokine-activated apoptosis in vertebrate cells. Ceramides 146-154 mitogen-activated protein kinase 8 Homo sapiens 120-123 25168245-6 2015 The JNK inhibitor SP600125 blocked the phosphorylation and activation of nSMase1, which in turn blocked ceramide signaling and apoptosis. Ceramides 104-112 mitogen-activated protein kinase 8 Homo sapiens 4-7 25937892-8 2014 Up-regulation of the ER stress-associated apoptosis promoting transcription factor CHOP and p-JNK suggested that the antitumor activity of ceramide is owing to activation of apoptotic ER stress. Ceramides 139-147 mitogen-activated protein kinase 8 Homo sapiens 94-97 24997497-5 2014 The present study showed that CAPE activated neutral sphingomyelinase (N-SMase), which led to the ceramide-mediated activation of MAPKs, including extracellular signal-regulated kinase (ERK), Jun N-terminus kinase (JNK), and p38 MAPK. Ceramides 98-106 mitogen-activated protein kinase 8 Homo sapiens 215-218 24190701-12 2014 Further, bortezomib-induced pro-apoptotic c-Jun N-terminal kinase (JNK) activation was also associated with ceramide production. Ceramides 108-116 mitogen-activated protein kinase 8 Homo sapiens 42-65 24190701-12 2014 Further, bortezomib-induced pro-apoptotic c-Jun N-terminal kinase (JNK) activation was also associated with ceramide production. Ceramides 108-116 mitogen-activated protein kinase 8 Homo sapiens 67-70 23065795-5 2012 Inhibition of de novo ceramide synthesis using chemical inhibitors blocked the ability of gammaT and gammaT3 to induce apoptosis as detected by Annexin V-FITC/PI assay and to activate JNK/CHOP/DR5 pro-apoptotic signaling thereby demonstrating the involvement of de novo ceramide synthesis in gammaT- and gammaT3-induced apoptosis. Ceramides 22-30 mitogen-activated protein kinase 8 Homo sapiens 184-187 23065795-6 2012 CONCLUSION: Taken together, data show that both gammaT and gammaT3 induce apoptosis via de novo ceramide synthesis dependent activation of JNK/CHOP/DR5 pro-apoptotic signaling. Ceramides 96-104 mitogen-activated protein kinase 8 Homo sapiens 139-142 22935424-5 2012 Salubrinal inhibited ceramide-induced inositol-requiring enzyme 1alpha (IRE1alpha)/apoptosis signal regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) phosphorylation. Ceramides 21-29 mitogen-activated protein kinase 8 Homo sapiens 152-155 21943220-7 2011 RESULTS: Ceramide-treated cells exhibited the characteristics of autophagy and JNK pathway activation. Ceramides 9-17 mitogen-activated protein kinase 8 Homo sapiens 79-82 22445853-3 2012 Here, we show that both ceramide and loss of Isc1p lead to the activation of Hog1p, the MAPK of the high osmolarity glycerol (HOG) pathway that is functionally related to mammalian p38 and JNK. Ceramides 24-32 mitogen-activated protein kinase 8 Homo sapiens 189-192 21708940-9 2011 The addition of sphingomyelinase, ceramide, or a proteasome inhibitor all led to retention of IRAK-1 at the cell membrane and to increased JNK phosphorylation. Ceramides 34-42 mitogen-activated protein kinase 8 Homo sapiens 139-142 22652149-7 2012 Inhibition of the ceramide-responsive JNK and PP2A pathways did not abolish the effects of ceramide, and JNK phosphorylation was unresponsive to ceramide; however, ceramide significantly inhibited phosphorylation of Akt. Ceramides 18-26 mitogen-activated protein kinase 8 Homo sapiens 38-41 21943220-8 2011 Inhibition of JNK pathway could block the ceramide-induced autophagy and the up-regulation of LC3 expression. Ceramides 42-50 mitogen-activated protein kinase 8 Homo sapiens 14-17 21943220-10 2011 CONCLUSIONS: Ceramide could induce autophagy in human nasopharyngeal carcinoma cells, and activation of JNK pathway was involved in ceramide-induced autophagy and LC3 expression. Ceramides 132-140 mitogen-activated protein kinase 8 Homo sapiens 104-107 21364631-3 2010 Inhibition of JNK activation with sphingomyelinase inhibitors (20 muM desipramine, 20 muM imipramine), with the protein kinase C-delta (PKCdelta) inhibitor rottlerin (10 muM), and with the specific PKCtheta pseudosubstrate inhibitor (30 muM) indicates that ceramide and phosphorylation by PKCdelta and PKCtheta mediate gal-1-induced JNK activation. Ceramides 257-265 mitogen-activated protein kinase 8 Homo sapiens 14-17 20110572-7 2010 Both SFA and ceramide activated PKC-zeta and the mitogen-activated protein kinases Erk, JNK, and p38. Ceramides 13-21 mitogen-activated protein kinase 8 Homo sapiens 88-91 19060920-5 2009 In this study, we used human cancer cell lines CNE2 and Hep3B to investigate the role of JNK-mediated Beclin 1 expression in ceramide-induced autophagic cell death. Ceramides 125-133 mitogen-activated protein kinase 8 Homo sapiens 89-92 19060920-11 2009 In addition, inhibition of JNK activity by SP600125 could inhibit autophagy induction by ceramide. Ceramides 89-97 mitogen-activated protein kinase 8 Homo sapiens 27-30 19337026-2 2009 Like amino acid starvation, ceramide triggers autophagy by interfering with the mTOR-signaling pathway, and by dissociating the Beclin 1:Bcl-2 complex in a c-Jun N-terminal kinase 1 (JNK1)-mediated Bcl-2 phosphorylation-dependent manner. Ceramides 28-36 mitogen-activated protein kinase 8 Homo sapiens 156-181 19337026-2 2009 Like amino acid starvation, ceramide triggers autophagy by interfering with the mTOR-signaling pathway, and by dissociating the Beclin 1:Bcl-2 complex in a c-Jun N-terminal kinase 1 (JNK1)-mediated Bcl-2 phosphorylation-dependent manner. Ceramides 28-36 mitogen-activated protein kinase 8 Homo sapiens 183-187 19060920-7 2009 JNK was activated in these two cell lines exposed to ceramide and the phosphorylation of c-Jun also increased. Ceramides 53-61 mitogen-activated protein kinase 8 Homo sapiens 0-3 18820034-7 2009 Thus, conversion of sphingomyelin to ceramide in basolateral membranes of intestinal cells rapidly activates JNK to inhibit a cAMP-gated K(+) conductance and thereby attenuates Cl(-) secretion. Ceramides 37-45 mitogen-activated protein kinase 8 Homo sapiens 109-112 18820034-0 2009 Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 19-22 19029119-0 2009 Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. Ceramides 48-56 mitogen-activated protein kinase 8 Homo sapiens 8-12 18948750-0 2008 Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 118-121 18948750-1 2008 Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal Kinase (JNK). Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 73-96 18948750-1 2008 Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal Kinase (JNK). Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 98-101 18270325-0 2008 Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 30-33 18270325-8 2008 Ceramide caused ASK1-regulated p38 mitogen-activated protein kinase (MAPK) and JNK activation, as well as activation of the endoplasmic reticulum (ER) stress cascade, and pharmacologic or siRNA-mediated inhibition of p38 MAPK or JNK partially reduced ceramide-induced mitochondria-mediated apoptosis. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 79-82 18270325-8 2008 Ceramide caused ASK1-regulated p38 mitogen-activated protein kinase (MAPK) and JNK activation, as well as activation of the endoplasmic reticulum (ER) stress cascade, and pharmacologic or siRNA-mediated inhibition of p38 MAPK or JNK partially reduced ceramide-induced mitochondria-mediated apoptosis. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 229-232 18270325-9 2008 Furthermore, ceramide-induced ASK1, p38, and JNK phosphorylation and cell apoptosis were inhibited by Txnip siRNA transfection. Ceramides 13-21 mitogen-activated protein kinase 8 Homo sapiens 45-48 18270325-10 2008 Taken together, we show that ceramide exhibits a mechanism of transcriptional regulation involving up-regulation of Txnip expression, also induced by etoposide, which results in ASK1 activation, ER stress, and p38 and JNK phosphorylation, all leading to apoptosis. Ceramides 29-37 mitogen-activated protein kinase 8 Homo sapiens 218-221 17005604-10 2007 p38 and JNK stimulation by CML-collagen was almost entirely blocked when formation of ROS was inhibited and was partially reduced by NO and ceramide inhibitors. Ceramides 140-148 mitogen-activated protein kinase 8 Homo sapiens 8-11 17828457-7 2007 Pharmacological inhibition of JNK kinase, as well as inhibition of ROS by the reducing agent N-acetylcysteine, prevented ceramide accumulation and capsaicin-induced cell death. Ceramides 121-129 mitogen-activated protein kinase 8 Homo sapiens 30-33 17828457-9 2007 These data reveal JNK as an upstream regulator of ceramide production. Ceramides 50-58 mitogen-activated protein kinase 8 Homo sapiens 18-21 16969513-8 2006 Furthermore, we observed that paclitaxel, ceramide, or combo-induced EGFR phosphorylation was inhibited by EGFR inhibitor, PD153035, while paclitaxel, ceramide, or combo-induced JNK and ERK phosphorylation was blocked by EGFR inhibitor, PD153035 and ERK inhibitor, U126. Ceramides 42-50 mitogen-activated protein kinase 8 Homo sapiens 178-181 16413574-10 2006 These data indicate that TNF inhibits endothelium-dependent NO-mediated dilation of coronary arterioles by ceramide-induced activation of JNK and subsequent production of superoxide via xanthine oxidase. Ceramides 107-115 mitogen-activated protein kinase 8 Homo sapiens 138-141 16479073-0 2006 Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK. Ceramides 0-9 mitogen-activated protein kinase 8 Homo sapiens 107-110 16479073-7 2006 The ceramide level was reduced significantly, and this was associated with the downregulation of apoptotic signaling molecules, such as PKC-alpha and JNK, in the lesional epidermis of psoriasis patients. Ceramides 4-12 mitogen-activated protein kinase 8 Homo sapiens 150-153 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 95-103 mitogen-activated protein kinase 8 Homo sapiens 29-50 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 95-103 mitogen-activated protein kinase 8 Homo sapiens 52-55 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 95-103 mitogen-activated protein kinase 8 Homo sapiens 157-160 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 95-103 mitogen-activated protein kinase 8 Homo sapiens 157-160 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 138-146 mitogen-activated protein kinase 8 Homo sapiens 29-50 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 138-146 mitogen-activated protein kinase 8 Homo sapiens 52-55 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 138-146 mitogen-activated protein kinase 8 Homo sapiens 157-160 16524368-4 2006 We provide evidence that the Jun N-terminal kinase (JNK) signaling pathway mediates Abeta- and ceramide-induced apoptosis: Both Abeta and ceramide activated JNK phosphorylation, and subsequent AP-1 DNA binding activity; JNK siRNA decreased AP-1 DNA binding, DP5 expression and reduced cell death. Ceramides 138-146 mitogen-activated protein kinase 8 Homo sapiens 157-160 15905098-4 2005 Ceramide also selectively altered the phosphorylation state of members of the MAPK superfamily, causing dephosphorylation of ERK1/2 and hyperphosphorylation of p38 MAP kinases, but not affecting the phosphorylation of JNK or ERK5. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 218-221 15769735-2 2005 Several studies have also described ceramide (CER), a lipid second messenger, as a major contributor in mediating UV light-induced c-Jun N-terminal kinase (JNK) activation and cell death. Ceramides 36-44 mitogen-activated protein kinase 8 Homo sapiens 131-154 15769735-2 2005 Several studies have also described ceramide (CER), a lipid second messenger, as a major contributor in mediating UV light-induced c-Jun N-terminal kinase (JNK) activation and cell death. Ceramides 36-44 mitogen-activated protein kinase 8 Homo sapiens 156-159 15769735-2 2005 Several studies have also described ceramide (CER), a lipid second messenger, as a major contributor in mediating UV light-induced c-Jun N-terminal kinase (JNK) activation and cell death. Ceramides 46-49 mitogen-activated protein kinase 8 Homo sapiens 131-154 15769735-2 2005 Several studies have also described ceramide (CER), a lipid second messenger, as a major contributor in mediating UV light-induced c-Jun N-terminal kinase (JNK) activation and cell death. Ceramides 46-49 mitogen-activated protein kinase 8 Homo sapiens 156-159 12738796-3 2003 Importantly, the MLK member MLK3/SPRK has been shown recently to be a direct target of ceramide and tumor necrosis factor-alpha (TNF-alpha) and to mediate the TNF-alpha and ceramide-induced JNK activation in Jurkat cells. Ceramides 87-95 mitogen-activated protein kinase 8 Homo sapiens 190-193 15520191-2 2004 Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 91-118 15520191-2 2004 Ceramide is known to potently activate a number of stress-regulated enzymes, including the c-Jun NH(2)-terminal kinase (JNK). Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 120-123 15520191-4 2004 Here, we report that ceramide promotes apoptosis in A549 cells by a mechanism involving JNK. Ceramides 21-29 mitogen-activated protein kinase 8 Homo sapiens 88-91 15520191-5 2004 The JNK inhibitor SP600125 proved effective at protecting cells from the lethal effects of ceramide. Ceramides 91-99 mitogen-activated protein kinase 8 Homo sapiens 4-7 15520191-8 2004 Ceramide was found to inhibit c-Jun phosphorylation, suggesting that JNK-mediated phosphorylation of c-Jun is not likely involved in ceramide-induced apoptosis. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 69-72 15520191-10 2004 On the other hand, ceramide promoted phosphorylation of Bim and induced translocation of active JNK from the nucleus to the cytoplasm and mitochondrial fraction. Ceramides 19-27 mitogen-activated protein kinase 8 Homo sapiens 96-99 15520191-11 2004 Ceramide-mediated changes in localization of JNK were consistent with the observed changes in phosphorylation status of c-Jun and Bim. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 45-48 15520191-14 2004 These results suggest that JNK may participate in ceramide-induced apoptosis in A549 cells by a mechanism involving Bim. Ceramides 50-58 mitogen-activated protein kinase 8 Homo sapiens 27-30 12738796-3 2003 Importantly, the MLK member MLK3/SPRK has been shown recently to be a direct target of ceramide and tumor necrosis factor-alpha (TNF-alpha) and to mediate the TNF-alpha and ceramide-induced JNK activation in Jurkat cells. Ceramides 173-181 mitogen-activated protein kinase 8 Homo sapiens 190-193 12738796-10 2003 Thus, our findings imply that some of the biological functions of JNK activators, such as TNF-alpha and ceramide, may be attributed to their ability to block cell responses to growth and survival factors acting through the ERK/MAPK pathway. Ceramides 104-112 mitogen-activated protein kinase 8 Homo sapiens 66-69 12646059-11 2003 Ceramide also activated the JNK pathway, but had no effect on ERK and p38 MAPKs. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 28-31 12676512-6 2003 However, the mechanisms how ceramide directly activates enzymes such as JNK and PP2A are still not clear. Ceramides 28-36 mitogen-activated protein kinase 8 Homo sapiens 72-75 12770554-6 2003 Immunocytochemistry using the same antibodies shows that phospho-JNK are localized in the neurites of control neurons and translocate to the nucleus where phospho-c-Jun concurrently appears upon ceramide-induced apoptosis. Ceramides 195-203 mitogen-activated protein kinase 8 Homo sapiens 65-68 12504027-5 2002 Specific inhibition of dMLK and MLK3 significantly attenuates activation of JNK by ceramide in vivo without affecting ceramide-induced p38 or ERK activation. Ceramides 83-91 mitogen-activated protein kinase 8 Homo sapiens 76-79 11354249-2 2001 Ceramide has been found to be a second messenger, which activates the c-jun N-terminal kinase (JNK) that is required for apoptotic cell death. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 70-93 11480555-11 2001 Ceramide activates stress-activated protein kinases like c-jun N-terminal kinase (JNK) and thus affects transcription pathways involving c-jun. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 57-80 11480555-11 2001 Ceramide activates stress-activated protein kinases like c-jun N-terminal kinase (JNK) and thus affects transcription pathways involving c-jun. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 82-85 11354249-2 2001 Ceramide has been found to be a second messenger, which activates the c-jun N-terminal kinase (JNK) that is required for apoptotic cell death. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 95-98 11354249-9 2001 Inhibition of ceramide production by desipramine (25-50 microM) reduced UV-induced JNK activation in both 293 and Jurkat cells; and protects 293 cells from UV-induced apoptosis. Ceramides 14-22 mitogen-activated protein kinase 8 Homo sapiens 83-86 11354249-12 2001 These results suggest that UV-induced JNK activation and apoptosis can be mediated through a ceramide dependent or an independent pathway. Ceramides 93-101 mitogen-activated protein kinase 8 Homo sapiens 38-41 11001916-7 2000 It is therefore proposed that PKCzeta regulates the PC-PLC/ASMase pathway, and it is hypothesized that the resultant ceramide accumulation mediates the activation of the SEK/JNK module by LPS. Ceramides 117-125 mitogen-activated protein kinase 8 Homo sapiens 174-177 11181043-0 2001 UVA radiation stimulates ceramide production: relationship to oxidative stress and potential role in ERK, JNK, and p38 activation. Ceramides 25-33 mitogen-activated protein kinase 8 Homo sapiens 106-109 11152959-1 2000 Previous studies have demonstrated that a number of biochemical actions of ceramide are mediated through protein kinase signalling pathways, such as p42/p44 mitogen-activated protein kinase (p42/p44 MAPK) and c-Jun N-terminal directed protein kinase (JNK). Ceramides 75-83 mitogen-activated protein kinase 8 Homo sapiens 251-254 11152959-6 2000 The possibility that growth arrest could be mediated by JNK was discounted on the basis that PDGF, as well as ceramide, stimulated JNK in these cells. Ceramides 110-118 mitogen-activated protein kinase 8 Homo sapiens 131-134 11241551-11 2001 Ceramide induced a strong and prolonged activation of c-Jun N-terminal Kinase (JNK) that correlated very well with the time course of cell death. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 54-77 11241551-11 2001 Ceramide induced a strong and prolonged activation of c-Jun N-terminal Kinase (JNK) that correlated very well with the time course of cell death. Ceramides 0-8 mitogen-activated protein kinase 8 Homo sapiens 79-82