PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30542809-1	2019	Tolterodine is metabolized to an active 5-hydroxymethyl tolterodine (5-HMT) by CYP2D6.	Tolterodine Tartrate	0-11	histamine N-methyltransferase	Homo sapiens	71-74	
23497983-6	2013	Fesoterodine, 5-HMT, and tolterodine resulted in significantly increased (two- to five-fold) values of the apparent dissociation constant for specific [N-methyl-(3)H] scopolamine methyl chloride binding in the detrusor muscle and parotid gland, with little effect on the corresponding values of the maximal number of binding sites.	Tolterodine Tartrate	25-36	histamine N-methyltransferase	Homo sapiens	16-19	
19145494-3	2009	5-HMT is formed via biotransformation of both fesoterodine and tolterodine, albeit by different metabolising enzymes, viz.	Tolterodine Tartrate	63-74	histamine N-methyltransferase	Homo sapiens	2-5	
21352267-1	2011	WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine.	Tolterodine Tartrate	42-53	histamine N-methyltransferase	Homo sapiens	143-146	
21352267-1	2011	WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine.	Tolterodine Tartrate	74-85	histamine N-methyltransferase	Homo sapiens	89-92	
21352267-1	2011	WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine.	Tolterodine Tartrate	74-85	histamine N-methyltransferase	Homo sapiens	143-146	
21352267-2	2011	The formation of 5-HMT from tolterodine occurs via CYP2D6, and some subjects are poor metabolizers CYP2D6.	Tolterodine Tartrate	28-39	histamine N-methyltransferase	Homo sapiens	19-22	
21352267-7	2011	AIMS: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine.	Tolterodine Tartrate	6-17	histamine N-methyltransferase	Homo sapiens	53-56	
21352267-7	2011	AIMS: Tolterodine and 5-hydroxymethyl tolterodine (5-HMT) are equipotent active moieties of tolterodine; 5-HMT is the singular active moiety of fesoterodine.	Tolterodine Tartrate	38-49	histamine N-methyltransferase	Homo sapiens	53-56	
21352267-8	2011	Formation of 5-HMT from fesoterodine and tolterodine occurs via esterases and CYP2D6 respectively.	Tolterodine Tartrate	41-52	histamine N-methyltransferase	Homo sapiens	15-18	
19835561-0	2009	The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine.	Tolterodine Tartrate	75-86	histamine N-methyltransferase	Homo sapiens	90-93	
19835561-1	2009	This review highlights the design and development of fesoterodine (Toviaz) as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), which is also the active metabolite of tolterodine, for the treatment of overactive bladder (OAB).	Tolterodine Tartrate	107-118	histamine N-methyltransferase	Homo sapiens	122-125	
19956551-7	2009	It is unique in that it shares the same active metabolite as tolterodine, 5-hydoxymethyltolterodine (5-HMT); however, this conversion is established via ubiquitous esterases and not via the cytochrome P450 system, thus providing a faster and more efficient conversion to 5-HMT.	Tolterodine Tartrate	61-72	histamine N-methyltransferase	Homo sapiens	103-106	
19956551-7	2009	It is unique in that it shares the same active metabolite as tolterodine, 5-hydoxymethyltolterodine (5-HMT); however, this conversion is established via ubiquitous esterases and not via the cytochrome P450 system, thus providing a faster and more efficient conversion to 5-HMT.	Tolterodine Tartrate	61-72	histamine N-methyltransferase	Homo sapiens	273-276	
29128914-2	2017	We developed and validated a simple, rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma.	Tolterodine Tartrate	184-195	histamine N-methyltransferase	Homo sapiens	253-256	
29995258-5	2018	Tolterodine and its therapeutically equipotent metabolite formed via CYP2D6 pathway, 5-HMT, inhibit multiple cardiac ion currents (IKr, INa, ICaL).	Tolterodine Tartrate	0-11	histamine N-methyltransferase	Homo sapiens	87-90