PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2840263-9 1988 TGF-beta decreased iodide uptake stimulated by forskolin or 8-bromo-cAMP. Colforsin 47-56 transforming growth factor beta 1 Homo sapiens 0-8 24912820-15 2014 Treatment of PSC with PGE2 or forskolin suppressed both TGFbeta-stimulated collagen synthesis and PDGF-stimulated DNA synthesis. Colforsin 30-39 transforming growth factor beta 1 Homo sapiens 56-63 3040721-8 1987 Forskolin, a direct activator of adenylate cyclase, also blocked induction of c-sis mRNA by thrombin and TGF-beta and inhibited the release of PDGF activity into the media of these cells. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 105-113 32053631-7 2020 More generally, dermal, cardiac and lung fibroblast responses to TGFbeta1 could be enhanced by increasing YAP nuclear levels (with GPCR ligands LPA, S1P, thrombin or Rho activator) and inhibited by decreasing nuclear YAP (with Rho inhibitor, forskolin, latrunculin B or 2-deoxy-glucose). Colforsin 242-251 transforming growth factor beta 1 Homo sapiens 65-73 30711170-3 2019 METHODS: SCAPs were stimulated with an activator of cAMP (forskolin) in the presence of either TGF-beta1 or a TGF-beta1 inhibitor. Colforsin 58-67 transforming growth factor beta 1 Homo sapiens 95-104 30711170-3 2019 METHODS: SCAPs were stimulated with an activator of cAMP (forskolin) in the presence of either TGF-beta1 or a TGF-beta1 inhibitor. Colforsin 58-67 transforming growth factor beta 1 Homo sapiens 110-119 30711170-8 2019 Moreover, the TGF-beta1 inhibitor synergized the effect of forskolin on the expression of type I collagen and runt-related transcription factor 2. Colforsin 59-68 transforming growth factor beta 1 Homo sapiens 14-23 30711170-9 2019 The results of Western blotting revealed that forskolin attenuated the unregulated expression of the phosphorylation of Smad3 and ERK induced by TGF-beta1, and a cAMP inhibitor (H89) antagonized this effect. Colforsin 46-55 transforming growth factor beta 1 Homo sapiens 145-154 29898378-7 2018 Treatment of OA synoviocytes with forskolin (10 muM) increased intracellular cAMP levels and reduced TGF-beta1-stimulated COL1A1, alpha-SMA, and TIMP-1 expression, with no change in PLOD2 expression. Colforsin 34-43 transforming growth factor beta 1 Homo sapiens 101-110 29898378-8 2018 Forskolin also reduced TGF-beta1-stimulated procollagen I and alpha-SMA content as well as synoviocyte migration and proliferation. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 23-32 3372537-6 1988 Pretreatment of cultures with 50 microM forskolin, a potent activator of adenylyl cyclase, completely blocked B chain transcription by thrombin and TGF-beta, but did not inhibit A chain transcription induced by TGF-beta. Colforsin 40-49 transforming growth factor beta 1 Homo sapiens 148-156 2846977-7 1988 TGF-beta also reduced forskolin and (Bu)2cAMP-induced T production (greater than 85% decrease), indicating that TGF-beta can inhibit steroidogenesis distal to the formation of cAMP. Colforsin 22-31 transforming growth factor beta 1 Homo sapiens 0-8 2846977-7 1988 TGF-beta also reduced forskolin and (Bu)2cAMP-induced T production (greater than 85% decrease), indicating that TGF-beta can inhibit steroidogenesis distal to the formation of cAMP. Colforsin 22-31 transforming growth factor beta 1 Homo sapiens 112-120 30984775-9 2019 Both BAY 41-2272 and forskolin alone reduced TGF-beta induced collagen and fibronectin de novo synthesis as well as deposition. Colforsin 21-30 transforming growth factor beta 1 Homo sapiens 45-53 30984775-11 2019 Furthermore, the TGF-beta induced expression of fibrilar alpha-smooth muscle actin was reduced by BAY 41-2272 and this effect was strengthened by forskolin. Colforsin 146-155 transforming growth factor beta 1 Homo sapiens 17-25 30984775-12 2019 In addition, BAY 41-2272 and forskolin reduced TGF-beta induced beta-catenin. Colforsin 29-38 transforming growth factor beta 1 Homo sapiens 47-55 21612641-7 2011 The TGF-beta1 stimulation of alpha-SMA, CTGF, COL1A2 and COL3A1 was greatly inhibited by concomitant treatment with forskolin, especially in DC-derived cells. Colforsin 116-125 transforming growth factor beta 1 Homo sapiens 4-13 21957188-6 2012 TGFB1 exposure caused a 70%-99% decrease in basal transepithelial electrical resistance (R(TE), a sensitive indicator of barrier integrity), while a significant decrease in anion secretory response to forskolin was detected at the highest levels of TGFB1 exposure employed. Colforsin 201-210 transforming growth factor beta 1 Homo sapiens 0-5 21612641-8 2011 In contrast, TGF-beta1 stimulation of FN1-EDA showed similar levels of reduction with the addition of forskolin in all three cell types. Colforsin 102-111 transforming growth factor beta 1 Homo sapiens 13-22 19151320-7 2009 Activation of protein kinase A (PKA) by forskolin or iloprost resulted in a significant inhibition of SM-alpha-actin expression induced by TGF-beta, and this was associated with inhibition of both SRF expression and activity, but not of Smad-mediated gene transcription. Colforsin 40-49 transforming growth factor beta 1 Homo sapiens 139-147 17428796-8 2007 In lung fibroblasts, inhibition of the TGFbeta1-stimulated CCN2/CTGF by PGE(2), butaprost, or forskolin is due to p38, ERK, and JNK MAP kinase inhibition that is cAMP-dependent. Colforsin 94-103 transforming growth factor beta 1 Homo sapiens 39-47 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 transforming growth factor beta 1 Homo sapiens 0-32 18287089-0 2008 Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. Colforsin 213-222 transforming growth factor beta 1 Homo sapiens 34-42 18287089-7 2008 We previously demonstrated that JNK1 phosphorylation by TGFbeta1 is also critical for TGFbeta1-induced CCN2/CTGF expression, and forskolin partially reduces levels of phosphorylated JNK1. Colforsin 129-138 transforming growth factor beta 1 Homo sapiens 86-94 17428796-12 2007 Whereas forskolin reduces TGFbeta1-stimulated expression of CCN2/CTGF by 35% and JNK activation in gingival fibroblasts, micromolar PGE(2)-stimulated JNK in gingival fibroblasts and opposes the inhibitory effects of cAMP on CCN2/CTGF expression. Colforsin 8-17 transforming growth factor beta 1 Homo sapiens 26-34 11138844-4 2000 After TGF-beta1 treatment, the basal, procaterol- and forskolin-stimulated cAMP accumulations were also decreased. Colforsin 54-63 transforming growth factor beta 1 Homo sapiens 6-15 17325033-5 2007 Induction of CREB phosphorylation with forskolin or 6bnz-cAMP mimics TGFbeta"s inhibitory effect on cyclin A expression. Colforsin 39-48 transforming growth factor beta 1 Homo sapiens 69-76 16353668-4 2005 A Northern blot analysis with the use of a radiolabeled cDNA probe, and immunodetection with antibodies directed against SF-1, demonstrated that the Sf-1 transcript and the SF-1 protein levels were lowered by TGF-beta in Y-1 adrenocortical cells, both in untreated and adenylyl cyclase activator, forskolin-treated cells. Colforsin 297-306 transforming growth factor beta 1 Homo sapiens 209-217 14654784-5 2003 Using either an artificial SMAD3/4-dependent reporter construct or the natural TGF-beta target, plasminogen activator inhibitor-1, we show that membrane-permeable dibutyryl cAMP, and other intracellular cAMP-elevating agents such as the phosphodiesterase inhibitor isobutyl-methylxanthine, the adenylate cyclase activator forskolin, or exogenous prostaglandin E2 (PGE2), interfere with TGF-beta-induced SMAD-specific gene transactivation. Colforsin 322-331 transforming growth factor beta 1 Homo sapiens 79-87 16959941-5 2006 Treatment with 10 microM forskolin or isoproterenol increased cAMP production and cAMP response element binding protein (CREB) phosphorylation in cardiac fibroblasts and inhibited serum- or TGF-beta-stimulated collagen synthesis by 37% or more. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 190-198 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 125-133 15625562-6 2004 We also demonstrated that in H295R cells TGF-beta inhibited both basal and forskolin-stimulated accumulation of CYP17 mRNA. Colforsin 75-84 transforming growth factor beta 1 Homo sapiens 41-49 12738687-6 2003 The inhibitory effects of PGE2 on TGF-beta1-induced alpha-SMA expression are mimicked by an EP2 selective agonist, butaprost, and by forskolin-induced direct activation of adenyl cyclase. Colforsin 133-142 transforming growth factor beta 1 Homo sapiens 34-43 12525251-5 2003 When TGFbeta1 was added simultaneously with forskolin, the production of cortisol and 11-hydroxyandrostenedione was decreased by 85% whereas that of deoxycortisol was increased. Colforsin 44-53 transforming growth factor beta 1 Homo sapiens 5-13 12525251-7 2003 We observed that TGFbeta1 strongly inhibits forskolin-induced steroid 11beta-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-induced aldosterone synthase activity and CYP11B2 mRNA levels. Colforsin 44-53 transforming growth factor beta 1 Homo sapiens 17-25 12388073-4 2002 Neither recombinant TGF-beta nor Ad-TGF beta infection affected baseline I(sc); however, exposure to > or = 1 ng/ml TGF-beta led to a significant (30-50%) reduction in the I(sc) responses to forskolin, vasoactive intestinal peptide, and cholera toxin (agents that evoke Cl(-) secretion via cAMP mobilization) and to the cell-permeant dibutyryl cAMP. Colforsin 194-203 transforming growth factor beta 1 Homo sapiens 119-127 11162896-3 2000 Cells were also treated with different concentration of TGFbeta1 in the presence of forskolin, combined steroid production was measured at the end of 48 h and after 3 h incubation with 22R-hydroxycholesterol. Colforsin 84-93 transforming growth factor beta 1 Homo sapiens 56-64 10595920-6 1999 Treatment with forskolin but not phorbol 12-myristate 13-acetate (PMA) also inhibited TGF-beta1-induced apoptosis. Colforsin 15-24 transforming growth factor beta 1 Homo sapiens 86-95 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 47-56 11013125-6 2000 Forskolin, a stimulator of cyclic AMP, blocked TGF- beta induced CTGF expression and reduced the basal level of CTGF, whereas an inhibitor that blocks the MAP kinase signaling pathway (PD 98059) significantly enhanced TGF- beta induced CTGF expression. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 218-227 9788104-5 1998 RESULTS: TGF-beta 1-induced collagen synthesis in HCC SMC was inhibited by receptor-mediated (PGE1) and non-receptor-mediated (forskolin) increases in cAMP synthesis, as well as the cell-permeable analog, dibutyryl cAMP. Colforsin 127-136 transforming growth factor beta 1 Homo sapiens 9-19 9071561-0 1997 Downregulation of TGF-beta 1 gene expression in anterior pituitary cells treated with forskolin. Colforsin 86-95 transforming growth factor beta 1 Homo sapiens 18-28 9292955-9 1997 In contrast, both TSH (1 mU/mL) and forskolin (16 microM) decreased TGF beta 1 mRNA expression to about 70%, and this effect was abolished when follicles were pretreated with iodide (40 microM KI) in a concentration known to inhibit TSH action on cyclic adenosine monophosphate (cAMP) formation and proliferation. Colforsin 36-45 transforming growth factor beta 1 Homo sapiens 68-78 9365188-11 1997 However, removal of the serum or the addition of forskolin or phorbol ester (TPA) induced a rapid elevation of aromatase mRNA and the switching of aromatase transcripts to exon 1c in the cells, whereas TGFbeta almost abolished the expression of aromatase mRNA. Colforsin 49-58 transforming growth factor beta 1 Homo sapiens 202-209 9071561-3 1997 Treatment with a dose of forskolin (5 microM), known to induce PRL gene transcription, significantly inhibited TGF-beta 1 levels in culture medium and TGF-beta 1 mRNA levels in cellular extracts. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 111-121 9071561-3 1997 Treatment with a dose of forskolin (5 microM), known to induce PRL gene transcription, significantly inhibited TGF-beta 1 levels in culture medium and TGF-beta 1 mRNA levels in cellular extracts. Colforsin 25-34 transforming growth factor beta 1 Homo sapiens 151-161 9071561-4 1997 Nuclear run-off transcription analysis revealed that the forskolin effect on TGF-beta 1 mRNA expression is due to reduced transcription initiation rates. Colforsin 57-66 transforming growth factor beta 1 Homo sapiens 77-87 8623837-7 1996 However, transforming growth factor-beta 1 inhibited forskolin-stimulated androstenedione production to near basal levels and increased progesterone 1.4- to 2-fold while suppressing P450c17 enzyme activity to near basal levels, but it did not affect 3 beta HSD activity. Colforsin 53-62 transforming growth factor beta 1 Homo sapiens 9-42 8623837-8 1996 Forskolin-stimulated immunodetectable P450c17 alpha protein was markedly inhibited by transforming growth factor-beta 1. Colforsin 0-9 transforming growth factor beta 1 Homo sapiens 86-119 8623837-9 1996 In addition, transforming growth factor-beta 1 markedly inhibited the forskolin-stimulation of P450c17 messenger ribonucleic acid, while not significantly altering P450scc or 3 beta HSD messenger ribonucleic acid expression. Colforsin 70-79 transforming growth factor beta 1 Homo sapiens 13-46 8623837-11 1996 Transforming growth factor-beta 1 inhibited forskolin stimulation of androstenedione production through the inhibition of P450c17 expression. Colforsin 44-53 transforming growth factor beta 1 Homo sapiens 0-33 7622573-6 1995 TGF-beta 1 treatment of cardiomyocytes also decreased the ability of forskolin to augment cAMP accumulation in intact cells and stimulate adenylyl cyclase activity. Colforsin 69-78 transforming growth factor beta 1 Homo sapiens 0-10 7536747-5 1995 In the case of purified Schwann cells, treatment with TGF-beta 1 increases their proliferation, and it promotes a pre- or nonmyelinating Schwann cell phenotype characterized by increased NCAM expression, decreased NGF receptor expression, inhibition of the forskolin-mediated induction of the myelin protein P0, and induction of the Schwann cell transcription factor suppressed cAMP-inducible POU protein. Colforsin 257-266 transforming growth factor beta 1 Homo sapiens 54-64 8206321-5 1994 TGF-beta also was found to interfere with DS and cortisol production by fetal zone cells in response to forskolin and dibutyryl cAMP. Colforsin 104-113 transforming growth factor beta 1 Homo sapiens 0-8 21153151-10 1995 Treatment of PCOS theca cells with EGF, FGF, TGFbeta and TPA resulted in the inhibition of forskolin-stimulated 17alpha-hydroxyprogesterone production. Colforsin 91-100 transforming growth factor beta 1 Homo sapiens 45-52 8027214-2 1994 Treatment of thecal cells with epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF beta), and tetradecanoyl phorbol acetate (TPA) resulted in the inhibition of forskolin- and dibutyryl cAMP-stimulated 17 alpha-hydroxylase activity and 17 alpha-hydroxyprogesterone and dehydroepiandrosterone production. Colforsin 208-217 transforming growth factor beta 1 Homo sapiens 94-125 8027214-2 1994 Treatment of thecal cells with epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF beta), and tetradecanoyl phorbol acetate (TPA) resulted in the inhibition of forskolin- and dibutyryl cAMP-stimulated 17 alpha-hydroxylase activity and 17 alpha-hydroxyprogesterone and dehydroepiandrosterone production. Colforsin 208-217 transforming growth factor beta 1 Homo sapiens 127-135 8027214-6 1994 In contrast to the inhibitory actions of EGF, FGF, and TGF beta on 17 alpha-hydroxylase expression, insulin and insulin-like growth factor-I enhanced forskolin-stimulated 17 alpha-hydroxylase activity. Colforsin 150-159 transforming growth factor beta 1 Homo sapiens 55-63 8166271-8 1994 Both forskolin (10 microM) and dibutyryl adenosine 3",5"-cyclic monophosphate (1 mM), but not phorbol 12-myristate 13-acetate (1 or 100 mM), were able to mimic ACTH actions in blunting the inhibitory effects of TGF-beta on DNA synthesis. Colforsin 5-14 transforming growth factor beta 1 Homo sapiens 211-219 1421693-6 1992 In addition, the increase in TGF-beta 1 mRNA level was not observed after treatment of the MCF-7 cell with other inducers of cell differentiation such as forskolin, DMF, HMBA and sodium butyrate. Colforsin 154-163 transforming growth factor beta 1 Homo sapiens 29-39