PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3019164-2	1986	Forskolin, a potent stimulator of adenyl cyclase that bypasses the hormone-receptor interactions, stimulated renin secretion in vitro from rabbit renal cortical slices in a concentration-dependent manner.	Colforsin	0-9	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	109-114	
3019164-3	1986	Renin secretion stimulated by submaximal concentration of forskolin was partly or completely antagonized or blocked by raising intracellular Ca2+ concentration by incubating slices in a high-K+ depolarizing medium, but renin secretion stimulated by the maximal effective concentration of forskolin was not inhibited by Ca2+.	Colforsin	58-67	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	0-5	
3019164-3	1986	Renin secretion stimulated by submaximal concentration of forskolin was partly or completely antagonized or blocked by raising intracellular Ca2+ concentration by incubating slices in a high-K+ depolarizing medium, but renin secretion stimulated by the maximal effective concentration of forskolin was not inhibited by Ca2+.	Colforsin	288-297	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	0-5	
3019164-4	1986	In addition, the maximal effective concentration of forskolin (10(-5) M) increased renin secretion by a fixed amount independent of medium (by inference, intracellular) Ca2+ concentration in the range of 10(-8) to 10(-6) M in a high-K+ medium.	Colforsin	52-61	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	83-88	
3019164-5	1986	Furthermore, the degree of stimulation of renin secretion by forskolin was greater with greater removal of the inhibitory effect of Ca2+ calmodulin pathway on renin secretion with use of potent calmodulin antagonists, suggesting that the stimulatory effect of cAMP on renin secretion may be maximal in the absence of the inhibitory influence of Ca2+.	Colforsin	61-70	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	42-47	
3019164-5	1986	Furthermore, the degree of stimulation of renin secretion by forskolin was greater with greater removal of the inhibitory effect of Ca2+ calmodulin pathway on renin secretion with use of potent calmodulin antagonists, suggesting that the stimulatory effect of cAMP on renin secretion may be maximal in the absence of the inhibitory influence of Ca2+.	Colforsin	61-70	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	159-164	
3019164-5	1986	Furthermore, the degree of stimulation of renin secretion by forskolin was greater with greater removal of the inhibitory effect of Ca2+ calmodulin pathway on renin secretion with use of potent calmodulin antagonists, suggesting that the stimulatory effect of cAMP on renin secretion may be maximal in the absence of the inhibitory influence of Ca2+.	Colforsin	61-70	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	159-164	
6324290-2	1984	The rabbit renal cortical slice system was chosen to examine the prostaglandin dependency of renin release directly stimulated by either a direct adenylate cyclase activator, forskolin, or a beta-agonist, isoproterenol.	Colforsin	175-184	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	93-98	
6324290-3	1984	In this study, we demonstrate that with forskolin (1 X 10(-5) M) or isoproterenol (1 X 10(-6) M), renin release was elevated 2-3 fold above control, and that this increase was shown to accompany a substantial increase in the tissue levels of cAMP (19.5 fold and 3.5 fold respectively).	Colforsin	40-49	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	98-103