PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9330595-7	1997	Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited.	Colforsin	55-64	interleukin 1 beta	Rattus norvegicus	9-18	
26527061-5	2016	In addition, we found that forskolin, a direct activator of adenylyl cyclase, significantly enhanced IL-1beta-induced STAT3 phosphorylation.	Colforsin	27-36	interleukin 1 beta	Rattus norvegicus	101-109	
15949713-12	2005	Since adenylate cyclase activator forskolin prevents the increase in NE-induced IL-1beta and IL-10, the up-regulatory effect of NE on those cytokines appears to be mediated, at least in part, by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels.	Colforsin	34-43	interleukin 1 beta	Rattus norvegicus	80-88	
11861327-7	2002	The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo.	Colforsin	173-182	interleukin 1 beta	Rattus norvegicus	96-104	
11861327-8	2002	Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin.	Colforsin	214-223	interleukin 1 beta	Rattus norvegicus	111-119	
11469536-6	2001	The cAMP-elevator forskolin did not augment the cytokine-induced elevation of sPLA2-IIa enzyme activity but significantly increased the IL-1beta-stimulated sPLA2-IIa mRNA contents in endothelial cells.	Colforsin	18-27	interleukin 1 beta	Rattus norvegicus	136-144	
11093787-7	2000	Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol.	Colforsin	25-34	interleukin 1 beta	Rattus norvegicus	84-92	
9930728-12	1999	The adenylyl cyclase activator forskolin and the cAMP analogue dibutyryl cAMP also reduced IL-1beta production.	Colforsin	31-40	interleukin 1 beta	Rattus norvegicus	91-99	
19398497-11	2009	Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor.	Colforsin	11-20	interleukin 1 beta	Rattus norvegicus	45-53	
9330595-7	1997	Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited.	Colforsin	174-183	interleukin 1 beta	Rattus norvegicus	9-18	
9231726-6	1997	Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation.	Colforsin	67-76	interleukin 1 beta	Rattus norvegicus	98-106	
2157407-3	1990	Human rIL-1 beta caused a dose-dependent inhibition of hCG-, 8-bromo cyclic AMP-, and forskolin-induced testosterone formation.	Colforsin	86-95	interleukin 1 beta	Rattus norvegicus	6-16	
8732506-7	1996	The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol.	Colforsin	114-123	interleukin 1 beta	Rattus norvegicus	34-43	
7711886-3	1995	A 10-min exposure of cells to IL-1 beta at a concentration of 1 x 10(-12) mol/l or higher significantly reduced the AVP-induced increases in cellular cAMP production but did not affect the 2 x 10(-8) mol/l forskolin-induced increases in cellular cAMP production.	Colforsin	206-215	interleukin 1 beta	Rattus norvegicus	30-39	
7711886-4	1995	The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production.	Colforsin	240-249	interleukin 1 beta	Rattus norvegicus	4-13	
7711886-4	1995	The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production.	Colforsin	240-249	interleukin 1 beta	Rattus norvegicus	172-181	
7528998-8	1994	IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin.	Colforsin	156-165	interleukin 1 beta	Rattus norvegicus	0-9	
7528998-8	1994	IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin.	Colforsin	156-165	interleukin 1 beta	Rattus norvegicus	110-119	
8505340-6	1993	Forskolin (7.5 microM), follicle-stimulating hormone (500 ng/ml) and luteinizing hormone (500 ng/ml) induced CAT activity following transfection with the -2698/32PGS.CAT, whereas gonadotropin-releasing hormone (10(-6) M) and interleukin-1 beta (30 ng/ml) had no effect.	Colforsin	0-9	interleukin 1 beta	Rattus norvegicus	225-243	
1846528-10	1991	In addition, IL-1 beta and TNF synergistically interacted with forskolin to stimulate phospholipase A2 release from the cells.	Colforsin	63-72	interleukin 1 beta	Rattus norvegicus	13-22	
8594915-7	1995	The addition of FSK or DBcAMP to IL-1 beta increased iNOS mRNA half-life over IL-1 beta treatment alone (10.6, 11.7 vs. 2.4 h, respectively).	Colforsin	16-19	interleukin 1 beta	Rattus norvegicus	78-87	
7507826-3	1994	After overnight incubation of isolated rat islets with 15 U/ml IL-1 beta and 11 mM glucose, sequential hourly insulin secretory responses to the same glucose concentration, 22 mM glucose, and 22 mM glucose plus forskolin were severely inhibited to 10-37% of the control value.	Colforsin	211-220	interleukin 1 beta	Rattus norvegicus	63-72	
1311232-12	1992	Similarly, IL-1 beta potentiated IL-6 release stimulated by forskolin and (Bu)2cAMP.	Colforsin	60-69	interleukin 1 beta	Rattus norvegicus	11-20	
1903893-7	1991	Furthermore, IL-1 beta inhibited forskolin (10(-5) mmol/L) and (Bu)2 cAMP (10(-2) mmol/L)-stimulated estrogen production, indicating a post-cyclic AMP site of action.	Colforsin	33-42	interleukin 1 beta	Rattus norvegicus	13-22	
31731189-5	2020	We found that FSK and STZ significantly increased the hyperphosphorylated tau level, pyroptosis-related protein in PC12 cell and rats" brain, and inhibited the activity of caspase-1 by caspase-1 inhibitor, caspase-1 siRNA, or incubated with Interleukin(IL)-1beta/IL-18 neutralizing antibody could notably alleviate the FSK and STZ induced PC12 cells damage and improve the cognitive disorder in ICV-FSK and ICV-STZ rats.	Colforsin	14-17	interleukin 1 beta	Rattus norvegicus	241-262	
29678208-10	2018	RESULTS: IL-1beta upregulated Nav1.7 mRNA and protein expressions in the TG explants, whereas NS398, PF-04418948, H89, or PKI-(6-22)-amide could all block this upregulation, and forskolin could also upregulate Nav1.7 mRNA and protein expressions.	Colforsin	178-187	interleukin 1 beta	Rattus norvegicus	9-17