PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1689374-1	1990	Treatment of PC12 cells with nerve growth factor (NGF), epidermal growth factor (EGF), or agents that raise intracellular cyclic AMP (cAMP) levels (e.g., forskolin) reduces the activity of calmodulin-dependent protein kinase III (CaM-PK III) over a period of 8 h. The mechanism of this effect of NGF has now been examined in more detail, making use of a mutant PC12 cell line (A126-1B2) that is deficient in cAMP-dependent protein kinase activity.	Colforsin	154-163	epidermal growth factor like 1	Rattus norvegicus	81-84	
7485469-6	1995	Stimulation of mesangial cells with the inflammatory mediator prostaglandin E2 (PGE2) or elevation of intracellular adenosine 3",5"-cyclic monophosphate (cAMP) by treatment with forskolin markedly blunted activation of MAP kinase induced by PDGF and EGF, but not by PMA.	Colforsin	178-187	epidermal growth factor like 1	Rattus norvegicus	250-253	
7788549-6	1995	Stimulation with inflammatory mediator PGE2 (50 mumol/L) or elevation of Intracellular cAMP by treatment of cells with forskolin (25 mumol/L) markedly blunted activation of MAP kinase induced by PDGF and EGF, but not PMA.	Colforsin	119-128	epidermal growth factor like 1	Rattus norvegicus	204-207	
7951586-5	1994	In addition, EGF inhibited DNA synthesis induced by forskolin, but enhanced the action of (Bu)2cAMP additively, which indicates that EGF attenuates DNA synthesis of granulosa cells by suppressing the activity of adenylate cyclase or cAMP production.	Colforsin	52-61	epidermal growth factor like 1	Rattus norvegicus	13-16	
7951586-5	1994	In addition, EGF inhibited DNA synthesis induced by forskolin, but enhanced the action of (Bu)2cAMP additively, which indicates that EGF attenuates DNA synthesis of granulosa cells by suppressing the activity of adenylate cyclase or cAMP production.	Colforsin	52-61	epidermal growth factor like 1	Rattus norvegicus	133-136	
7511481-0	1993	Forskolin and isoproterenol effect discrete responses on epidermal growth factor induced DNA synthesis in aortic smooth muscle cells.	Colforsin	0-9	epidermal growth factor like 1	Rattus norvegicus	57-80	
3030262-10	1986	EGF and insulin inhibited phosphorylase activation by exogenous cyclic AMP, and inhibited cyclic AMP accumulation induced by forskolin.	Colforsin	125-134	epidermal growth factor like 1	Rattus norvegicus	0-3	
18407464-8	2008	LPA did not affect cAMP levels after EGF treatment, and the reagents promoting cAMP production such as forskolin and cholera toxin also attenuated the EGF-induced ERK5 phosphorylation, indicating that the inhibitory effect of LPA on ERK5 inhibition via G(i/o) is not due to inhibition of adenylyl cyclase by Galpha(i/o).	Colforsin	103-112	epidermal growth factor like 1	Rattus norvegicus	151-154	
9145782-4	1997	The beta-adrenoceptor agonists, metaproterenol and isoproterenol, and other cAMP-elevating agents, such as glucagon, forskolin, and dibutyryl cAMP, potentiated both hepatocyte DNA synthesis and proliferation about 1.4-fold when cultured in combination with 20 ng/ml EGF.	Colforsin	117-126	epidermal growth factor like 1	Rattus norvegicus	266-269	
9834339-7	1997	Agents that activate PKA at different stages of the PKA activation pathway, including 3-isobutyl-1-methylxanthine (IBMX), forskolin, and cholera toxin, inhibited EGF-induced migration.	Colforsin	122-131	epidermal growth factor like 1	Rattus norvegicus	162-165