PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8536639-4 1996 Similarly, activation of the adenylyl cyclase-cAMP system with forskolin, 8-brom-cAMP or 3-isobutyl-1-methylxanthine (IBMX), also markedly elevated the level of pro-ANF mRNA abundance. Colforsin 63-72 natriuretic peptide A Rattus norvegicus 165-168 16326837-5 2005 Our results indicate that ANP(1-28), CNP(1-22) and C-ANF inhibited cAMP synthesis stimulated by the physiological agonists histamine and 5-hydroxytryptamine or directly by forskolin. Colforsin 172-181 natriuretic peptide A Rattus norvegicus 53-56 10644591-1 2000 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin 122-131 natriuretic peptide A Rattus norvegicus 207-233 10644591-1 2000 Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion. Colforsin 122-131 natriuretic peptide A Rattus norvegicus 235-238 11860154-8 2002 An increase in ANP secretion by N/OFQ was also partially blocked by the pretreatment of forskolin. Colforsin 88-97 natriuretic peptide A Rattus norvegicus 15-18 10644591-3 2000 By contrast, a higher regimen of forskolin (10 microM) promoted a 20- to 30-fold increase in basal cAMP production, which was accompanied by the abolition of contractile activity and ANP release. Colforsin 33-42 natriuretic peptide A Rattus norvegicus 183-186 10067864-7 1999 The effect of TSH on [125I]ANF binding was mimicked by forskolin and (Bu)2cAMP, indicating receptor up-regulation via a cAMP pathway. Colforsin 55-64 natriuretic peptide A Rattus norvegicus 27-30 8166260-4 1994 Consistent with these results, N6-2"-O-dibutyryl cAMP (DBcAMP, 10 microM) and/or forskolin (0.1 microM) simultaneously increased cAMP production, calcium influx, and ANP release in these cells, with both DBcAMP- and forskolin-induced ANP secretion being fully abolished in the presence of 0.1 microM nifedipine. Colforsin 81-90 natriuretic peptide A Rattus norvegicus 166-169 7531819-4 1994 ANP(10(-7)M) inhibited cAMP accumulation stimulated by forskolin (10(-6)M) in control rat parotid acinar cells by about 34%, however, in PT-treated cells, the inhibitory effect of ANP was attenuated completely. Colforsin 55-64 natriuretic peptide A Rattus norvegicus 0-3 7524470-1 1994 Atrial natriuretic peptide (ANP), sodium nitroprusside and hydroxylamine increased cGMP accumulation in rat parotid acinar cells both in the presence and absence of forskolin but in a different manner. Colforsin 165-174 natriuretic peptide A Rattus norvegicus 0-26 8166260-4 1994 Consistent with these results, N6-2"-O-dibutyryl cAMP (DBcAMP, 10 microM) and/or forskolin (0.1 microM) simultaneously increased cAMP production, calcium influx, and ANP release in these cells, with both DBcAMP- and forskolin-induced ANP secretion being fully abolished in the presence of 0.1 microM nifedipine. Colforsin 81-90 natriuretic peptide A Rattus norvegicus 234-237 8166260-5 1994 Taken together, these results suggest that PAF, DBcAMP, and forskolin promote ANP secretion in spontaneously beating cardiomyocytes via the activation of a cAMP-dependent, nifedipine-sensitive myocardial calcium channel and that calcium influx is a major requirement for cAMP-induced ANP secretion in this system. Colforsin 60-69 natriuretic peptide A Rattus norvegicus 78-81 8166260-5 1994 Taken together, these results suggest that PAF, DBcAMP, and forskolin promote ANP secretion in spontaneously beating cardiomyocytes via the activation of a cAMP-dependent, nifedipine-sensitive myocardial calcium channel and that calcium influx is a major requirement for cAMP-induced ANP secretion in this system. Colforsin 60-69 natriuretic peptide A Rattus norvegicus 284-287 6540085-4 1984 ANF was also able to inhibit the stimulatory effects of hormones on adenylate cyclase activity and of agents such as F- and forskolin which activate adenylate cyclase by receptor- independent mechanism. Colforsin 124-133 natriuretic peptide A Rattus norvegicus 0-3 2461711-0 1988 Inhibition of atrial natriuretic peptide secretion by forskolin in noncontracting cultured atrial myocytes. Colforsin 54-63 natriuretic peptide A Rattus norvegicus 14-40 3031034-4 1987 In addition, pertussis toxin treatment enhanced guanosine 5"-O-(thiotriphosphate) and isoproterenol-stimulated adenylate cyclase activities and attenuated the ANF-mediated inhibition of basal, isoproterenol-, and forskolin-stimulated adenylate cyclase activities. Colforsin 213-222 natriuretic peptide A Rattus norvegicus 159-162 3924044-5 1985 Furthermore the inhibition of isoproterenol- and FSK-stimulated adenylate cyclase activities by ANF was also abolished by ninhibin. Colforsin 49-52 natriuretic peptide A Rattus norvegicus 96-99 8386616-7 1993 However, 10 microM of AA markedly enhanced forskolin-induced irANF secretion and pro-ANF mRNA abundance of the cultured cells. Colforsin 43-52 natriuretic peptide A Rattus norvegicus 63-66 8386616-9 1993 We thus conclude that AA acts alone or in synergism with forskolin to stimulate the secretion and production of ANF in rat hypothalamic neurons; this latter effect may operate at the genomic level and is mediated, at least in part, through the protein kinase A dependent pathway. Colforsin 57-66 natriuretic peptide A Rattus norvegicus 112-115 1826878-0 1991 Forskolin-induced immunoreactive atrial natriuretic peptide (ANP) secretion and pro-ANP messenger ribonucleic acid expression of hypothalamic neurons in culture: modulation by glucocorticoids. Colforsin 0-9 natriuretic peptide A Rattus norvegicus 33-59 1699748-10 1990 In contrast, drugs known to increase the concentration of intracellular Ca2+ in myocytes, Bay K8644 (3 and 6 microns) and forskolin (0.14 microM), significantly inhibited the stretch-stimulated ANP release. Colforsin 122-131 natriuretic peptide A Rattus norvegicus 194-197 1699751-5 1990 Furthermore, our data suggest that the form of ANP released from these cultures, following either forskolin treatment alone or forskolin treatment followed by acute high potassium depolarisation, was atriopeptin III (ANP5-28). Colforsin 98-107 natriuretic peptide A Rattus norvegicus 47-50 1699751-5 1990 Furthermore, our data suggest that the form of ANP released from these cultures, following either forskolin treatment alone or forskolin treatment followed by acute high potassium depolarisation, was atriopeptin III (ANP5-28). Colforsin 127-136 natriuretic peptide A Rattus norvegicus 47-50 2839333-4 1988 An increase in ANF concentration from 10 pM to 1 microM caused a 40% decrease in forskolin-stimulated or isoproterenol-stimulated adenylate cyclase activities (IC50 5 nM) in rat lung plasma membranes. Colforsin 81-90 natriuretic peptide A Rattus norvegicus 15-18 2952521-3 1987 The released ANF inhibited forskolin-stimulated aldosterone secretion from rat zona glomerulosa cell suspensions, and this biological effect was comparable to that of the synthetic C-terminal part of the prohormone (Arg-101-Tyr-126). Colforsin 27-36 natriuretic peptide A Rattus norvegicus 13-16 2429651-0 1986 The phorbol ester induced atrial natriuretic peptide secretion is stimulated by forskolin and Bay K8644 and inhibited by 8-bromo-cyclic GMP. Colforsin 80-89 natriuretic peptide A Rattus norvegicus 26-52 3157852-5 1985 In addition ANF was also able to inhibit the stimulation exerted by NaF and forskolin which activate adenylate cyclase by receptor independent mechanism. Colforsin 76-85 natriuretic peptide A Rattus norvegicus 12-15 3157852-6 1985 Similarly, the stimulatory effects of N-Ethylcarboxamide adenosine (NECA), NaF and forskolin on adenylate cyclase in posterior pituitary homogenates were also inhibited by ANF. Colforsin 83-92 natriuretic peptide A Rattus norvegicus 172-175 2982657-4 1985 In addition, ANF was also able to inhibit the stimulation exerted by forskolin which activates adenylate cyclase by receptor-independent mechanism. Colforsin 69-78 natriuretic peptide A Rattus norvegicus 13-16