PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3263120-3 1988 The dose-response curve of interleukin 1 beta effect on adenylate cyclase activity showed a significant inhibition of basal enzyme activity at 1 pM concentration, while the inhibition of forskolin stimulated adenylate cyclase activity was more pronounced and evident at both 0.01 and 1 pM concentrations. Colforsin 187-196 interleukin 1 beta Homo sapiens 27-45 1534816-7 1992 Treatment of cell cultures with forskolin (25 microM) induced IL-1 beta transcripts in granulosa but not theca cells. Colforsin 32-41 interleukin 1 beta Homo sapiens 62-71 2541588-7 1989 Interleukin-1 beta also inhibited forskolin- and dibutyryl cAMP-stimulated testosterone production. Colforsin 34-43 interleukin 1 beta Homo sapiens 0-18 1648785-3 1991 In this study we show that in LPS-activated human monocytes, elevated cAMP concentrations (induced by either prostaglandin E2, forskolin or dibutyrylcyclic AMP) affected specifically secretion of IL-1 beta; the amount of secreted IL-1 beta was clearly reduced whereas the cell-associated level remained unchanged. Colforsin 127-136 interleukin 1 beta Homo sapiens 196-205 2503616-7 1989 Finally, IL-1 beta also suppressed the forskolin-induced secretion of estradiol. Colforsin 39-48 interleukin 1 beta Homo sapiens 9-18 31434103-0 2019 Insights image for Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages. Colforsin 19-28 interleukin 1 beta Homo sapiens 78-86 11350835-3 2001 Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC). Colforsin 130-139 interleukin 1 beta Homo sapiens 24-32 31086288-7 2019 Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P < 0.01). Colforsin 108-117 interleukin 1 beta Homo sapiens 6-14 31086288-7 2019 Basal IL-1beta secretion increased from 584 to 2696 pg/mL (P < 0.01) in nigericin-activated macrophages; forskolin dose-dependently reduced the nigericin-induced secretion of mature IL-1beta (P < 0.01). Colforsin 108-117 interleukin 1 beta Homo sapiens 185-193 31086288-8 2019 Forskolin also inhibited the IL-1beta secretion from activated human primary macrophages. Colforsin 0-9 interleukin 1 beta Homo sapiens 29-37 31086288-9 2019 CONCLUSIONS: Forskolin inhibits the NLRP3 inflammasome activation and the secretion of mature IL-1beta, in human macrophages. Colforsin 13-22 interleukin 1 beta Homo sapiens 94-102 18586957-2 2008 In the present study, PGE(2), forskolin, and short-acting (salbutamol) and long-acting (salmeterol and formoterol) beta(2)-adrenoceptor agonists reduced the expression of ICAM-1 and the release of GM-CSF evoked by IL-1beta in ASM cells. Colforsin 30-39 interleukin 1 beta Homo sapiens 214-222 18586957-3 2008 IL-1beta-induced IL-8 release was also repressed by PGE(2) and forskolin, whereas the beta(2)-adrenoceptor agonists were ineffective. Colforsin 63-72 interleukin 1 beta Homo sapiens 0-8 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 interleukin 1 beta Homo sapiens 0-17 31086288-0 2019 Forskolin attenuates the NLRP3 inflammasome activation and IL-1beta secretion in human macrophages. Colforsin 0-9 interleukin 1 beta Homo sapiens 59-67 31086288-2 2019 Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activation and interleukin-1beta (IL-1beta) secretion in human macrophages. Colforsin 71-80 interleukin 1 beta Homo sapiens 153-170 27673556-8 2016 In vitro exposure of myometrial cells to stretch and IL-1beta increased OTR levels and reduced basal and forskolin-stimulated cAMP and PKA activity, as judged by phospho-cAMP response element-binding protein levels, but neither stretch nor IL-1beta had any effect on PKA or EPAC1 levels. Colforsin 105-114 interleukin 1 beta Homo sapiens 53-61 24161591-3 2014 We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter. Colforsin 14-23 interleukin 1 beta Homo sapiens 60-68 24161591-3 2014 We found that forskolin enhanced progesterone-repression of IL-1beta-driven COX-2 expression in association with delayed IL-1beta-induced nuclear phospho-p65 entry and reduced NF-kappaB binding to the COX-2 promoter. Colforsin 14-23 interleukin 1 beta Homo sapiens 121-129 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 interleukin 1 beta Homo sapiens 200-208 12952251-5 2003 Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. Colforsin 0-9 interleukin 1 beta Homo sapiens 66-88 11350835-3 2001 Chronic incubation with IL-1beta or RV caused a significant increase (approximately 3- and approximately 2-fold, respectively) in forskolin (FSK)-stimulated cAMP production, suggesting a sensitization of adenylyl cyclase (AC). Colforsin 141-144 interleukin 1 beta Homo sapiens 24-32 11350835-4 2001 The observed augmentation of FSK-stimulated cAMP formation by IL-1beta was completely abrogated by pretreatment with an IL-1 receptor antagonist or cycloheximide, demonstrating that the effect is mediated via the IL-1 receptor 1 (IL-1R1) and that de novo protein synthesis is required. Colforsin 29-32 interleukin 1 beta Homo sapiens 62-70 7488646-8 1995 IL-1 beta also decreased forskolin-stimulated cyclic AMP production, which again indicates increased cyclic AMP metabolism. Colforsin 25-34 interleukin 1 beta Homo sapiens 0-9 9316506-7 1997 Despite the marked increase in Bmax, however, IL-1 beta depressed adenosine 3",5"-cyclic monophosphate (cAMP) responses to isoproterenol and forskolin, a direct activator of AC (P < 0.001 by analysis of variance for both). Colforsin 141-150 interleukin 1 beta Homo sapiens 46-55 11112151-6 2000 PGE(2) increased adenylate cyclase activity in a concentration dependent manner, and forskolin, a direct activator of adenylate cyclase, caused a marked increase in IL-1 beta-dependent COX-2, suggesting the existence of a causal relationship between the two events. Colforsin 85-94 interleukin 1 beta Homo sapiens 165-174 10815617-13 1999 Similarly, forskolin (10, 50 or 100 microM) can also reverse the inhibition of PGE2 on increased COX activity in IL-1beta treated HUVEC. Colforsin 11-20 interleukin 1 beta Homo sapiens 113-121 9409229-5 1997 Cicaprost as well as forskolin significantly inhibited TNF-alpha- and IL-1 beta-induced cell surface expression of ICAM-1 and VCAM-1. Colforsin 21-30 interleukin 1 beta Homo sapiens 70-79 7626041-3 1995 The response to forskolin, a direct stimulus of adenylyl cyclase, was also significantly enhanced, indicating that the effect of interleukin-1 beta was targeted to the enzyme itself. Colforsin 16-25 interleukin 1 beta Homo sapiens 129-147 8589264-8 1995 Forskolin (an adenylate cyclase activator) produced lipolytic effect similar to those of IL-1 beta, while indomethacin (an inhibitor of prostaglandin [PG] production) fully blocked the release of radioactivity induced by IL-1 beta and greatly increased triglyceride synthesis. Colforsin 0-9 interleukin 1 beta Homo sapiens 221-230 8242337-9 1993 Longer term treatment with IL-1 beta in forskolin pre-treated astrocytes enhanced the calcium response to quisqualate stimulation, a glutamate neurotransmitter receptor agonist. Colforsin 40-49 interleukin 1 beta Homo sapiens 27-36 8144314-5 1993 A role for cyclic AMP in IL-1 beta induction was suggested since forskolin was sufficient to induce IL-1 beta release from HPBM. Colforsin 65-74 interleukin 1 beta Homo sapiens 25-34 8144314-5 1993 A role for cyclic AMP in IL-1 beta induction was suggested since forskolin was sufficient to induce IL-1 beta release from HPBM. Colforsin 65-74 interleukin 1 beta Homo sapiens 100-109