PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 34-43 mitogen-activated protein kinase 1 Homo sapiens 86-89 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 100-137 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 139-142 11997240-4 2002 HS and cAMP-elevating drugs (forskolin and dibutyryl cAMP-acetoxymethyl ester) similarly suppressed extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase activation and superoxide formation in response to N-formylmethionyl-leucyl-phenylalanine (fMLP) stimulation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 148-151 12039071-5 2002 Forskolin (0.001-100 microM) activated ERK, while inhibition of protein kinase A (PKA) by H89 (0.01-10 microM) suppressed pERK levels and all GnRH-stimulated gonadotropin subunit transcripts. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 39-42 11410589-3 2001 Adenylate cyclase activation with forskolin (FSK) caused a time-dependent increase in ERK activity and translocation from cytoplasm to nucleus, which correlated with an increase in StAR mRNA levels, StAR protein accumulation, and steroidogenesis. Colforsin 45-48 mitogen-activated protein kinase 1 Homo sapiens 86-89 11410589-4 2001 Similarly, ERK inhibition led to a reduction in the levels of FSK-stimulated StAR mRNA, StAR protein, and steroid secretion. Colforsin 62-65 mitogen-activated protein kinase 1 Homo sapiens 11-14 11410589-6 2001 This conclusion was supported by our demonstration of an ERK-dependent increase in the binding of SF-1 from FSK-treated Y1 nuclei to three consensus double-stranded DNA sequences from the StAR promoter region. Colforsin 108-111 mitogen-activated protein kinase 1 Homo sapiens 57-60 11444827-4 2001 We showed that forskolin + IBMX inhibited serum-induced ERK activities, Rb hyperphosphorylation, Cdk2 activity, and p27(Kip1) downregulation and caused G1 arrest in MIA PaCa-2 cells. Colforsin 15-24 mitogen-activated protein kinase 1 Homo sapiens 56-59 11553671-3 2001 Pharmacologically increasing intracellular cAMP levels in cultured cortical astroglia by treatment with dbcAMP or forskolin attenuated FGF-2-induced ERK phosphorylation and glial cell proliferation. Colforsin 114-123 mitogen-activated protein kinase 1 Homo sapiens 149-152 11445280-0 2001 Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. Colforsin 11-20 mitogen-activated protein kinase 1 Homo sapiens 142-180 11445280-2 2001 Using an immortalized hippocampal cell line, HiB5, we have tried a pairing of forskolin with KCl depolarization, which acts as an ERK and CREB kinase activator in hippocampal neurons, to investigate if an activation of ERK and phosphorylation of CREB at the critical regulatory site, serine 133 might be coupled in differentiation. Colforsin 78-87 mitogen-activated protein kinase 1 Homo sapiens 130-133 11444827-5 2001 Furthermore, forskolin + IBMX protected pancreatic cells against apoptosis induced by prolonged inhibition of ERK activities by preventing Bcl-X(L) downregulation, activation of caspases 3, 6, 8, and 9, and PARP cleavage and by inducing Bad phosphorylation (ser112). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 110-113 10777769-7 2000 However, incubation of slices with forskolin, an activator of the cAMP-dependent protein kinase (PKA) cascade, did result in increases in active ERK and cAMP response element-binding protein (CREB) phosphorylation in area CA3. Colforsin 35-44 mitogen-activated protein kinase 1 Homo sapiens 145-148 11290527-3 2001 PGE(2) and forskolin inhibited mitogen-induced ERK activation. Colforsin 11-20 mitogen-activated protein kinase 1 Homo sapiens 47-50 10777769-8 2000 The forskolin-induced increase in active ERK was inhibited by U0126, whereas the increase in CREB phosphorylation was not, which suggests that in area CA3 the PKA cascade is not coupled to CREB phosphorylation via ERK. Colforsin 4-13 mitogen-activated protein kinase 1 Homo sapiens 41-44 10026223-6 1999 H-89 blocks ERK activation by forskolin, but weakly affects the response to NECA or UTP. Colforsin 30-39 mitogen-activated protein kinase 1 Homo sapiens 12-15 10779323-5 2000 The combined actions of EGF and forskolin resulted in potentiated activation of extracellular signal-regulated kinase (ERK) enzyme activity compared with EGF alone. Colforsin 32-41 mitogen-activated protein kinase 1 Homo sapiens 80-117 10779323-5 2000 The combined actions of EGF and forskolin resulted in potentiated activation of extracellular signal-regulated kinase (ERK) enzyme activity compared with EGF alone. Colforsin 32-41 mitogen-activated protein kinase 1 Homo sapiens 119-122 10779323-6 2000 Specific blockade of ERK activation was sufficient to block EGF-forskolin-induced synergistic activation of the alpha subunit reporter. Colforsin 64-73 mitogen-activated protein kinase 1 Homo sapiens 21-24 10779323-11 2000 Thus, synergistic activation of the alpha subunit gene induced by EGF-forskolin requires the ERK and JNK cascades and the recruitment of AP-1 to the CRE binding complex. Colforsin 70-79 mitogen-activated protein kinase 1 Homo sapiens 93-96 10077003-8 1999 Forskolin stimulation proceeded via the PKA pathway, and to a minor extent via the p38 and ERK MAPK pathways. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 91-94 10077003-8 1999 Forskolin stimulation proceeded via the PKA pathway, and to a minor extent via the p38 and ERK MAPK pathways. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 95-99 10026223-9 1999 In the presence of forskolin, Ro 31-8220 loses its ability to block UTP-stimulated ERK activation. Colforsin 19-28 mitogen-activated protein kinase 1 Homo sapiens 83-86 10688975-6 2000 Forskolin, a direct activator of adenylyl cyclase also stimulated ERK and P38 activities in these cells suggesting the invovement of cAMP in this process. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 66-69 9892211-3 1999 We have studied the effects of EGF, IGF-I, and the protein kinase A (PKA) activator forskolin on the activation of p42/ extracellular signal-regulated kinase (ERK)2, which is a key kinase in mediation of growth factor-induced mitogenesis in prostate cancer cells. Colforsin 84-93 mitogen-activated protein kinase 1 Homo sapiens 120-164 9892211-5 1999 EGF, IGF-I, and forskolin-induced PKA activity stimulate intracellular signaling pathways converging at the level of p42/ERK2. Colforsin 16-25 mitogen-activated protein kinase 1 Homo sapiens 121-125 9546582-9 1998 Cyclic AMP derivatives or cAMP generating agents such as PTH and forskolin inhibited ERK2 activation by bFGF and PDGF-BB suggesting a "cross-talk" between the two different signalling pathways activated by receptor tyrosine kinases and cAMP-dependent protein kinase. Colforsin 65-74 mitogen-activated protein kinase 1 Homo sapiens 85-89 8985363-7 1997 Both MAPK activation and IL-8 production were inhibited by forskolin, a potent inhibitor of Raf-1. Colforsin 59-68 mitogen-activated protein kinase 1 Homo sapiens 5-9 10684111-22 1997 Similarly, in agreement with a very recent report from David, M et al in NIH, in which they indicated that forskolin (30 mumol/L) inhibited IFN-beta-stimulated ERK activity by U 266 cells (J. Biol. Colforsin 107-116 mitogen-activated protein kinase 1 Homo sapiens 160-163 34606419-0 2021 Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2alpha/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis. Colforsin 83-92 mitogen-activated protein kinase 1 Homo sapiens 30-33 8759733-8 1996 Both PKC-dependent and -independent activation of ERK were sensitive to inhibition by forskolin or a cell-permeable cAMP analogue, dbcAMP. Colforsin 86-95 mitogen-activated protein kinase 1 Homo sapiens 50-53 8058064-8 1994 Forskolin (50 microM), isobutylmethylxanthine (0.5 mM), and forskolin/isobutylmethylxanthine in combination attenuated IGF-1-induced ERK activity in WT cells by 54, 55, and 75% respectively. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 133-136 34606419-7 2021 Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. Colforsin 30-39 mitogen-activated protein kinase 1 Homo sapiens 197-200 34606419-7 2021 Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. Colforsin 293-302 mitogen-activated protein kinase 1 Homo sapiens 197-200 7588214-5 1995 FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC-stimulated tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) as well as inhibited PKC-stimulated MAPK and Raf-1 activities. Colforsin 0-3 mitogen-activated protein kinase 1 Homo sapiens 168-175 7588214-5 1995 FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC-stimulated tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) as well as inhibited PKC-stimulated MAPK and Raf-1 activities. Colforsin 0-3 mitogen-activated protein kinase 1 Homo sapiens 177-181 8058064-8 1994 Forskolin (50 microM), isobutylmethylxanthine (0.5 mM), and forskolin/isobutylmethylxanthine in combination attenuated IGF-1-induced ERK activity in WT cells by 54, 55, and 75% respectively. Colforsin 60-69 mitogen-activated protein kinase 1 Homo sapiens 133-136 26494252-8 2016 Activation of cAMP/Creb pathway by forskolin prevented gstp1-2 expression, whereas U0126 suppressed Creb phosphorylation, thus setting up Creb as a proximal transmitter of Erk inhibitory effect. Colforsin 35-44 mitogen-activated protein kinase 1 Homo sapiens 172-175 30711170-9 2019 The results of Western blotting revealed that forskolin attenuated the unregulated expression of the phosphorylation of Smad3 and ERK induced by TGF-beta1, and a cAMP inhibitor (H89) antagonized this effect. Colforsin 46-55 mitogen-activated protein kinase 1 Homo sapiens 130-133 29574069-10 2018 It is important to note that the forskolin-induced potentiation of sensitivity to doxorubicin is accompanied by a strong inhibition of ERK1/2 phosphorylation, is mimicked by ERK inhibitor PD98059 and is prevented by pre-treatment with Protein Kinase A (PKA) and adenylate cyclase inhibitors. Colforsin 33-42 mitogen-activated protein kinase 1 Homo sapiens 135-138 29574069-11 2018 Altogether, our data indicate that forskolin sensitizes TNBC cells to doxorubicin via a mechanism depending on the cAMP/PKA-mediated ERK inhibition. Colforsin 35-44 mitogen-activated protein kinase 1 Homo sapiens 133-136 29422898-6 2018 Mechanistically, Forskolin and/or IL-4 activated ERK pathway in macrophages resulting in the upregulation of M2-associated molecules miR-124, arginase (Arg)1, and Mannose receptor C-type 1 (Mrc1), which was reversed by ERK inhibitors. Colforsin 17-26 mitogen-activated protein kinase 1 Homo sapiens 49-52 29422898-6 2018 Mechanistically, Forskolin and/or IL-4 activated ERK pathway in macrophages resulting in the upregulation of M2-associated molecules miR-124, arginase (Arg)1, and Mannose receptor C-type 1 (Mrc1), which was reversed by ERK inhibitors. Colforsin 17-26 mitogen-activated protein kinase 1 Homo sapiens 219-222 29422898-9 2018 Thus, our data indicate that Forskolin has potency to skew balance toward M2 affecting ERK pathway in macrophages and indirectly inhibit pathogenic CD4 T cells in the CNS leading to the suppression of autoimmune inflammation. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 87-90 26023836-5 2015 Interestingly, both forskolin and FTY720 dephosphorylated and activated PP2A, impairing proliferation and prostasphere formation and inducing changes in AKT and ERK phosphorylation. Colforsin 20-29 mitogen-activated protein kinase 1 Homo sapiens 161-164 24384504-8 2014 In contrast, forskolin-induced immediate ERK activation is unaffected by inhibition of protein synthesis or transcription. Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 41-44 25239597-6 2014 On the other hand, we found that a MEK inhibitor (PD98059) further enhanced the insulin-stimulated CFTR mRNA expression and the Cl(-) secretion in forskolin-stimulated A6 cells and that insulin induced slight, transient activation of ERK followed by significant inactivation of ERK. Colforsin 147-156 mitogen-activated protein kinase 1 Homo sapiens 234-237 25239597-6 2014 On the other hand, we found that a MEK inhibitor (PD98059) further enhanced the insulin-stimulated CFTR mRNA expression and the Cl(-) secretion in forskolin-stimulated A6 cells and that insulin induced slight, transient activation of ERK followed by significant inactivation of ERK. Colforsin 147-156 mitogen-activated protein kinase 1 Homo sapiens 278-281 24997451-7 2014 Forskolin dephosphorylated and activated PP2A, impairing proliferation and colonosphere formation, and inducing activation of caspase 3/7 and changes in AKT and ERK phosphorylation. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 161-164 24384504-4 2014 Forskolin also induces ERK activation, which plays important roles in LTP. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 23-26 24384504-5 2014 However, the mechanisms of forskolin-induced ERK activation are not clearly understood. Colforsin 27-36 mitogen-activated protein kinase 1 Homo sapiens 45-48 24384504-6 2014 Here we show that forskolin induces sustained ERK activation in the hippocampal slices. Colforsin 18-27 mitogen-activated protein kinase 1 Homo sapiens 46-49 24760659-7 2014 The activation of adenylate cyclase with Forskolin mimicked the PGE2-mediated enhancement of extracellular signal-regulated kinase (ERK) phosphorylation and ERRa target gene expression. Colforsin 41-50 mitogen-activated protein kinase 1 Homo sapiens 93-130 24760659-7 2014 The activation of adenylate cyclase with Forskolin mimicked the PGE2-mediated enhancement of extracellular signal-regulated kinase (ERK) phosphorylation and ERRa target gene expression. Colforsin 41-50 mitogen-activated protein kinase 1 Homo sapiens 132-135 24384504-7 2014 Further, blockade of protein synthesis or transcription inhibits forskolin-induced sustained ERK activation. Colforsin 65-74 mitogen-activated protein kinase 1 Homo sapiens 93-96 24384504-9 2014 Sustained ERK activation may contribute to forskolin-induced LTP in the hippocampus. Colforsin 43-52 mitogen-activated protein kinase 1 Homo sapiens 10-13 23000456-9 2012 High cAMP levels were compatible with normal ERK activation but, surprisingly, the adenylyl cyclase activator forskolin abolished ERK activation by MC1R, most likely by a cAMP-independent mechanism. Colforsin 110-119 mitogen-activated protein kinase 1 Homo sapiens 130-133 23690594-3 2013 Prosaptide stimulation of cells transfected with GPR37 or GPR37L1 induced the phosphorylation of ERK in a pertussis toxin-sensitive manner, stimulated (35)S-GTPgammaS binding, and promoted the inhibition of forskolin-stimulated cAMP production. Colforsin 207-216 mitogen-activated protein kinase 1 Homo sapiens 97-100 20015475-10 2010 Challenge of U87-MG cells with PGE(2), at concentrations that induced maximal CREB activation, or with forskolin inhibited extracellular signal-regulated kinase (ERK) phosphorylation. Colforsin 103-112 mitogen-activated protein kinase 1 Homo sapiens 123-160 22532442-4 2012 Forskolin (25 muM) and cAMP analogs (8-bromo-cAMP, dibutyryl-cAMP, and 8-chlorophenylthio-cAMP) stimulated ERK phosphorylation and neuritogenesis in NS-1 cells. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 107-110 21273660-10 2010 The obtained results indicate that PGL, ALLO and THDOC inhibited basal and forskolin-induced CRH gene promoter activity in the differentiated Neuro-2A cells and that these effects did not depend on the activation of PI3-K/Akt and ERK-MAPK pathways. Colforsin 75-84 mitogen-activated protein kinase 1 Homo sapiens 234-238 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 178-215 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 217-220 20107853-7 2010 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin 19-22 mitogen-activated protein kinase 1 Homo sapiens 256-260 20107853-8 2010 By a combination of immunostaining and pharmacological analyses, we show that FSK treatment increases cAMP levels in avian auditory supporting cells and that several ERK MAP inhibitors effectively block FSK-induced supporting cell proliferation. Colforsin 203-206 mitogen-activated protein kinase 1 Homo sapiens 166-169 20107853-10 2010 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin 38-41 mitogen-activated protein kinase 1 Homo sapiens 213-216 20107853-10 2010 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin 38-41 mitogen-activated protein kinase 1 Homo sapiens 217-221 20015475-12 2010 Inhibition of ERK by PGE(2) or by forskolin was rescued by treatment of cells with H-89 or by the dominant negative PKA construct. Colforsin 34-43 mitogen-activated protein kinase 1 Homo sapiens 14-17 21084381-6 2011 ERK activation was comparable for wild-type and mutant MC1R and was independent on cAMP because it was neither triggered by stimulation of cAMP synthesis with forskolin nor blocked by the adenylyl cyclase inhibitor 2",5"-dideoxyadenosine. Colforsin 159-168 mitogen-activated protein kinase 1 Homo sapiens 0-3 20015475-10 2010 Challenge of U87-MG cells with PGE(2), at concentrations that induced maximal CREB activation, or with forskolin inhibited extracellular signal-regulated kinase (ERK) phosphorylation. Colforsin 103-112 mitogen-activated protein kinase 1 Homo sapiens 162-165 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Colforsin 21-30 mitogen-activated protein kinase 1 Homo sapiens 79-82 19385062-3 2009 Forskolin stimulated angiogenesis of human endothelial cells and in vivo neovascularization, which was accompanied by phosphorylation of CREB, ERK, Akt, and endothelial nitric oxide synthase (eNOS) as well as NO production and VEGF expression. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 143-146 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 151-154 19385062-4 2009 Forskolin-induced CREB phosphorylation, VEGF promoter activity, and VEGF expression were blocked by the PKA inhibitor PKI.Moreover, phosphorylation of ERK by forskolin was inhibited by the MEK inhibitor PD98059, but not PKI. Colforsin 158-167 mitogen-activated protein kinase 1 Homo sapiens 151-154 19385062-9 2009 Small interfering RNA-mediated knockdown of Epac1 suppressed forskolin-induced angiogenesis and phosphorylation of ERK, Akt, and eNOS, but not CREB phosphorylation and VEGF expression. Colforsin 61-70 mitogen-activated protein kinase 1 Homo sapiens 115-118 18466337-0 2008 Forskolin induction of late-LTP and up-regulation of 5" TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 88-91 18571589-11 2008 The cAMP stimulators forskolin and IBMX abolished TSP-1-induced chemotaxis and ERK and p38 activation. Colforsin 21-30 mitogen-activated protein kinase 1 Homo sapiens 87-90 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 mitogen-activated protein kinase 1 Homo sapiens 85-88 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 63-104 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 52-89 17995938-9 2008 PACAP-38 and forskolin stimulated the activation of extracellular signal-regulated kinase (ERK), mitogen-activated protein kinase (MAP; p38 MAP kinase) and c-Jun N-terminal kinase (JNK). Colforsin 13-22 mitogen-activated protein kinase 1 Homo sapiens 91-94 17182884-10 2007 Furthermore, both atRA and forskolin suppressed HIV-induced mitogen-activated protein kinase 1 and 2 and Stat3 phosphorylation. Colforsin 27-36 mitogen-activated protein kinase 1 Homo sapiens 60-100 16973907-7 2006 In contrast, only the expression of AC1 enhanced forskolin-stimulated association of ERK with AC, demonstrated by coimmuno-isolation of ERK with Flag-tagged AC1, but not with Flag-tagged AC6. Colforsin 49-58 mitogen-activated protein kinase 1 Homo sapiens 136-139 16973907-9 2006 Indeed, we observed similar isoform-dependent association of AC1 with ERK, activation of ERK by stimulation of AC1 with forskolin, and AC1-dependent lengthening of doubling time, indicating that these properties of AC1 are cell autologous and likely result from AC1-dependent protein-protein interactions. Colforsin 120-129 mitogen-activated protein kinase 1 Homo sapiens 89-92 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 74-83 mitogen-activated protein kinase 1 Homo sapiens 42-45 16678346-6 2006 However, NAMDA enhanced the activation of ERK and CREB in the presence of forskolin (1.7-fold increase for pCREB, 2.1-fold increase for pERK2, p<0.05 from forskolin). Colforsin 158-167 mitogen-activated protein kinase 1 Homo sapiens 42-45 16678346-9 2006 The data showed that NAMDA enhances forskolin-induced ERK-CREB activation and potentiates forskolin-induced resistance to apoptosis. Colforsin 36-45 mitogen-activated protein kinase 1 Homo sapiens 54-57 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 118-155 16470843-4 2006 When cAMP levels were increased, using either forskolin or a cell permeable analogue of cAMP, the heregulin-induced phosphorylation of ERK was converted from transient to sustained and the heregulin-induced phosphorylation of Akt was synergistically increased. Colforsin 46-55 mitogen-activated protein kinase 1 Homo sapiens 135-138 15030385-3 2004 Here, we report that KCl and forskolin synergistically increase CCK gene transcription via protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) signalling pathways, activating cAMP response element-binding protein (CREB) associated with the CRE(- 80) element of the CCK promoter. Colforsin 29-38 mitogen-activated protein kinase 1 Homo sapiens 157-160 12727988-2 2003 In the present work we demonstrate that highly luteinized human granulosa cells obtained from in vitro fertilization patients respond to human LH as well as to forskolin in phosphorylation of extracellular-signal regulated kinases 1 and 2 (ERK1 and -2). Colforsin 160-169 mitogen-activated protein kinase 1 Homo sapiens 192-238 12807435-7 2003 Forskolin or brain-derived neurotropic factor (BDNF) induced a short ania-6 mRNA, that encodes the full-length cyclin, and this induction depended on ERK. Colforsin 0-9 mitogen-activated protein kinase 1 Homo sapiens 150-153 12679459-5 2003 Increasing cAMP by forskolin caused a protein kinase A-dependent increase of ERK activity (287 +/- 37%) in GH-omas and had no effect in NFPA. Colforsin 19-28 mitogen-activated protein kinase 1 Homo sapiens 77-80