PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31042404-5 2019 NHERF1 knockdown fully abrogated the ISO-, PGE2-, and FSK-induced IL-6 gene expression and cytokine production without affecting cAMP-mediated phosphodiesterase 4D (PDE4D) gene expression, phospho-cAMP response element-binding protein (p-CREB), and cAMP response element (CRE)-Luc, or PDGF-induced cyclin D1 expression. Colforsin 54-57 interleukin 6 Homo sapiens 66-70 24363043-7 2014 IL-6 production by BSMC was induced by Fsk and select G protein-coupled receptor (GPCR) agonists, though IL-6 levels did not directly correlate with global cAMP levels. Colforsin 39-42 interleukin 6 Homo sapiens 0-4 32454590-9 2017 By using cyclic adenosine monophosphate (cAMP)-arising reagent forskolin, cAMP is found to be involved in the up-regulation of IL-6 induction. Colforsin 63-72 interleukin 6 Homo sapiens 127-131 24363043-9 2014 IL-6 promoter mutations demonstrated that AP-1 and CRE transcription sites were required for Fsk to stimulate IL-6 expression. Colforsin 93-96 interleukin 6 Homo sapiens 0-4 24363043-9 2014 IL-6 promoter mutations demonstrated that AP-1 and CRE transcription sites were required for Fsk to stimulate IL-6 expression. Colforsin 93-96 interleukin 6 Homo sapiens 110-114 21234673-9 2011 These functional alterations were driven by elevated cAMP, as direct activation of adenylate cyclase by forskolin elicited similar alterations in VEGF and IL-6 production. Colforsin 104-113 interleukin 6 Homo sapiens 155-159 21734258-9 2011 However, RLN activation of RXFP1 induced a dose-dependent cAMP response, which when mimicked by forskolin also caused significantly increased (P < 0.05) secretion of IL6. Colforsin 96-105 interleukin 6 Homo sapiens 169-172 23268452-6 2011 IL-6 production in the supernatants of confluent monolayers cultured in the presence of the drugs or forskolin (24 h) was analyzed by enzyme-linked immunosorbent assay. Colforsin 101-110 interleukin 6 Homo sapiens 0-4 20663885-7 2010 Forskolin also stimulated expression of interleukin-6 but not osteoprotegerin (OPG), an inhibitor of RANKL. Colforsin 0-9 interleukin 6 Homo sapiens 40-53 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 15-19 20457835-5 2010 PGE(2) induces IL-6 mRNA and protein expression via a cAMP-dependent pathway, reaching maximal levels after 60 min of stimulation before declining to baseline levels at 6 h. Forskolin, an adenylyl cyclase activator, also stimulates IL-6 expression in human chondrocytes in a dose- and time-dependent fashion. Colforsin 174-183 interleukin 6 Homo sapiens 232-236 20457835-6 2010 Inhibition of downstream effectors of cAMP activity such as protein kinase A (PKA) or phosphatidylinositol 3 kinase (PI3K) blocks PGE(2)- and forskolin-induced IL-6 upregulation. Colforsin 142-151 interleukin 6 Homo sapiens 160-164 20457835-9 2010 p65 knockdown completely abrogates IL-6 mRNA synthesis in PGE(2)- and forskolin-primed chondrocytes. Colforsin 70-79 interleukin 6 Homo sapiens 35-39 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 61-65 20457835-10 2010 Cumulatively, our data show that PGE(2) and forskolin induce IL-6 expression in human chondrocytes via cAMP/PKA and PI3K-dependent pathways, which in turn regulate the activation and binding of p65 to the IL-6 promoter. Colforsin 44-53 interleukin 6 Homo sapiens 205-209 19850345-8 2009 To understand whether the inhibitory effect of thymulin on cytokine release is cAMP-dependent, Forskolin, a labdane diterpene known to elevate intracellular cAMP, was shown to reduce the secretion of IL-1beta and TNF-alpha, but not IL-6, an effect mimicked by dibutyryl-cAMP (dbcAMP), an analog of cAMP. Colforsin 95-104 interleukin 6 Homo sapiens 232-236 18205818-6 2008 Furthermore, forskolin also inhibited the LPS-induced levels of TNF-alpha, IL-12 p40, IL-23 p19 and IL-6, supporting the hypothesis that the effects of NE are mediated by cAMP. Colforsin 13-22 interleukin 6 Homo sapiens 100-104 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 81-84 19698236-5 2009 It is concluded that cis-elements including T-Ag, PU.1, c-Ets, XPF-1, P2 alphaA, IL6-6RE and RAR may inhibit lrp16 expression and hormone or its inhibitor such as corticosteroid, tamoxifen, forskolin, phenylephrine, inflammatory factors such as IL6, IFNgamma and TNFalpha, and chemotherapeutics 5-fluorouracil may participate in the regulation of lrp16 gene expression in negative manner. Colforsin 190-199 interleukin 6 Homo sapiens 245-248 19285039-7 2009 Treatment with forskolin, an agent that mimics axonal signaling, suppressed the expression of IL-6-inducible genes. Colforsin 15-24 interleukin 6 Homo sapiens 94-98 17395587-6 2007 The induction of IL-6 by salmeterol was dependent upon the beta(2) receptor and could also be induced by cAMP or cAMP-elevating agents forskolin and rolipram. Colforsin 135-144 interleukin 6 Homo sapiens 17-21 8393800-4 1993 This induction of IL-6 production could be achieved by reagents known to increase intracellular levels of cAMP, such as forskolin, prostaglandin E or pentoxifylline. Colforsin 120-129 interleukin 6 Homo sapiens 18-22 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 17-26 interleukin 6 Homo sapiens 188-192 14749354-7 2004 The induction by forskolin plus DHT or by either agent or by IL-6 alone was greatly inhibited by H-89, indicating the involvement of protein kinase A in the actions of forskolin, DHT, and IL-6. Colforsin 168-177 interleukin 6 Homo sapiens 61-65 11426771-6 2001 Interleukin 1beta, interleukin 6, and interleukin 8 levels after cardiopulmonary bypass were significantly (p < 0.05) lower in the colforsin group. Colforsin 134-143 interleukin 6 Homo sapiens 19-32 10816606-6 2000 Indeed, the cAMP agonist forskolin increased the binding of the transcription factors NF-IL-6 and C/EBPdelta to the CAAT box of the IL-6 promoter in nuclear extracts of astrocytes. Colforsin 25-34 interleukin 6 Homo sapiens 89-93 10816606-7 2000 Inhibition of the de novo synthesis of NF-IL-6 by cycloheximide or an antisense oligonucleotide reduced the enhancement of NF-IL-6 binding to the CAAT box and inhibited stimulation of IL-6 transcription by forskolin. Colforsin 206-215 interleukin 6 Homo sapiens 42-46 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Colforsin 37-46 interleukin 6 Homo sapiens 131-135 8034686-2 1994 IL-6 expression is induced in young human diploid fibroblasts (HDF) in response to a number of agents including fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate, double-stranded RNA, and forskolin. Colforsin 195-204 interleukin 6 Homo sapiens 0-4 12748876-4 2003 In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P<0.01). Colforsin 95-104 interleukin 6 Homo sapiens 181-185 12748876-7 2003 The production of IL-6 was markedly increased over the basal level after 24 h of treatment with forskolin (P<0.001) and 48 h of treatment (P<0.01) with cultured granulosa cells. Colforsin 96-105 interleukin 6 Homo sapiens 18-22 12651911-8 2003 Substantial qualitative and quantitative differences in PSA expression and AR occupancy of the PSA enhancer were observed when DHT-induced and ligand-independent activations of the AR were compared; forskolin stimulated PSA mRNA and protein expression, whereas IL-6 inhibited both DHT- and forskolin-stimulated expression. Colforsin 199-208 interleukin 6 Homo sapiens 261-265 11104733-5 2000 Moreover, stimulation with PGE(2), forskolin, or dibutyryl cAMP alone increased basal IL-6 secretion in a concentration-dependent manner. Colforsin 35-44 interleukin 6 Homo sapiens 86-90 9922315-6 1999 Forskolin mimicked the stimulatory effects of these neurotransmitters on IL-6 secretion, and the protein kinase inhibitor6-22 amide abolished the actions of VIP, CGRP, and norepinephrine, but not that of human recombinant IL-1beta, on IL-6 secretion. Colforsin 0-9 interleukin 6 Homo sapiens 73-77 9328832-13 1997 These results demonstrate PTH, forskolin, the PTHrP analog RS-66271, and IL-1 alpha stimulate IL-6 expression by stimulating gene transcription. Colforsin 31-40 interleukin 6 Homo sapiens 94-98 9328832-14 1997 The response to forskolin suggests that the messenger system mediated by PKA is sufficient to induce IL-6 expression. Colforsin 16-25 interleukin 6 Homo sapiens 101-105 8576941-6 1995 Amrinone at 26 mumol/l and NKH477 at 10 nmol/l also had a less marked inhibitory effect against the production of IL-6. Colforsin 27-33 interleukin 6 Homo sapiens 114-118 7529912-4 1994 Agents which mimicked (dibutyryl cAMP) or stimulated (isoproterenol and forskolin) cAMP formation were found to induce IL-6 release and their effects could be potentiated by 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor. Colforsin 72-81 interleukin 6 Homo sapiens 119-123 1319454-4 1992 IL-6 release over 24 h was stimulated by TSH (5000 microU/ml), by forskolin (0.01 mmol/l), by fetal calf serum (1-20%) and by epidermal growth factor (20 ng/ml). Colforsin 66-75 interleukin 6 Homo sapiens 0-4 1664173-6 1991 Conversely, the preincubation of pituitary cells with interleukin-6 for 20 min significantly reduced VIP- and forskolin-stimulated adenylate cyclase activity, as well as inositol phosphate production and free cytosolic calcium increase induced by TRH. Colforsin 110-119 interleukin 6 Homo sapiens 54-67 2192263-3 1990 On the basis of these and other experiments, we conclude that TNF and IL-1 apparently activate IL-6 gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor, whereas the pathway of IL-6 induction by forskolin is, in part, different. Colforsin 237-246 interleukin 6 Homo sapiens 219-223 2046859-0 1991 Release of interleukin-6 from anterior pituitary cell aggregates: developmental pattern and modulation by glucocorticoids and forskolin. Colforsin 126-135 interleukin 6 Homo sapiens 11-24 2046859-4 1991 The adenylate cyclase activator forskolin increased IL-6 release in aggregate cultures in the presence of DEX. Colforsin 32-41 interleukin 6 Homo sapiens 52-56 2233715-3 1990 The induction by interleukin-1, tumor necrosis factor, phorbol ester, or forskolin of IL-6-tk-cat chimeric constructs containing a single copy of the IL-6 DNA segment from -173 to -151 (MRE I) or from -158 to -145 (MRE II), which derive from within the multiple cytokine- and second-messenger-responsive enhancer (MRE) region, was strongly repressed by Dex in a wild-type GR-dependent fashion irrespective of the inducer used. Colforsin 73-82 interleukin 6 Homo sapiens 86-90 2511437-5 1989 The 115-base pair (bp) region from -225 to -111 in the IL-6 5"-flanking region, which shares nucleotide sequence similarity with the c-fos serum response (SRE) and adjacent AP-1-like (the CGTCA motif) elements, confers responsiveness to several reagents, including serum, forskolin, and phorbol ester, upon the heterologous herpesvirus thymidine kinase (TK) promoter. Colforsin 272-281 interleukin 6 Homo sapiens 55-59 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Colforsin 153-162 interleukin 6 Homo sapiens 41-45 34867348-7 2021 We showed that LPS-induced expression of IL-6 and IL-1beta was cAMP dependent, that IL-6 and IL-1beta expression were induced by direct cAMP activation (forskolin) and that RG0216 and deprenyl effectively reduced cAMP-mediated cytokine expression. Colforsin 153-162 interleukin 6 Homo sapiens 84-88 2119190-3 1990 Among the agents affecting the signal transduction pathways, forskolin significantly induced PSTI secretion whereas PMA or A23187 did not, suggesting that IL-6 induced PSTI secretion is mediated by cAMP dependent protein kinase A. Colforsin 61-70 interleukin 6 Homo sapiens 155-159 2511437-9 1989 Mutations in the AP-1-like site within AR1 (CGTCA----GTTCA) decreased inducibility of the chimeric IL-6/TK/chloramphenicol acetyltransferase gene by phorbol ester and by forskolin but not by serum, IL-1 alpha, or tumor necrosis factor. Colforsin 170-179 interleukin 6 Homo sapiens 99-103 2842790-6 1988 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin 15-24 interleukin 6 Homo sapiens 40-53 2536035-7 1989 Forskolin was also found to have a marked stimulatory effect on the expression of interferon-beta 2 mRNA expression. Colforsin 0-9 interleukin 6 Homo sapiens 82-99 2842790-6 1988 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin 15-24 interleukin 6 Homo sapiens 55-59 2842790-7 1988 The protein kinase inhibitor H-8, inhibiting preferentially cAMP-dependent kinase activity, reduced forskolin-stimulated IL-6 mRNA induction more strongly than TNF- or IL-1-driven IL-6 mRNA induction. Colforsin 100-109 interleukin 6 Homo sapiens 121-125