PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23388888-5 2013 Erk1/2 activation at 3min was mimicked by forskolin (adenylyl-cyclase activator), and was resistant to pertussis toxin (Gi inhibitor), suggesting a Gs protein signaling. Colforsin 42-51 mitogen-activated protein kinase 3 Homo sapiens 0-6 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 47-53 21843633-8 2011 Although alpha-tocopherol and alpha-tocopheryl phosphate did not directly bind CB1R, both alpha-TP and CB1R agonists inhibited forskolin-evoked Erk1/2 phosphorylation in a nonadditive manner. Colforsin 127-136 mitogen-activated protein kinase 3 Homo sapiens 144-150 21233840-3 2011 Here, we show that PP2A inactivation is a recurrent event in acute myeloid leukemia (AML), and that restoration of PP2A phosphatase activity by treatment with forskolin in AML cells blocks proliferation, induces caspase-dependent apoptosis and affects AKT and ERK1/2 activity. Colforsin 159-168 mitogen-activated protein kinase 3 Homo sapiens 260-266 21035520-4 2011 Forskolin treatment induced a rapid and potent ERK1/2 and p38MAPK phosphorylation; this cascade required PKA-AKAP interactions and led to downstream CREB-1/ATF-1 phosphorylation via ERK1/2-dependent but p38MAPK-independent mechanisms. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 182-188 21035520-5 2011 Interestingly both p38MAPK and ERK1/2 were involved in forskolin-induced hCG-secretion, suggesting the presence of additional p38MAPK-dependent but CREB-1/ATF-1-independent pathways. Colforsin 55-64 mitogen-activated protein kinase 3 Homo sapiens 31-37 21035520-8 2011 Forskolin effects on all these genes were suppressed by chemical inhibition of p38MAPK whereas only specific genes were sensitive to ERK1/2 inhibition. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 133-139 19176384-8 2009 Phosphorylation of ERK1/2 was PKA-independently inhibited by forskolin but not inhibited by Epac/Rap1 signaling, PKA modulation, or GPCR ligands. Colforsin 61-70 mitogen-activated protein kinase 3 Homo sapiens 19-25 20589829-4 2010 Interestingly, intracellular cAMP elevation upon forskolin pretreatment completely abrogated both ERK1/2 and STAT3 phosphorylation in response to leptin and was accompanied by a consistent CREB phosphorylation. Colforsin 49-58 mitogen-activated protein kinase 3 Homo sapiens 98-104 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 mitogen-activated protein kinase 3 Homo sapiens 173-179 20589829-6 2010 Importantly, pretreatment with the PKA inhibitor KT-5720 blocked the forskolin-induced CREB phosphorylation and prevented both the inhibition by forskolin of leptin-induced ERK1/2 and STAT3 phosphorylation and the PKA subunits down-regulation induced by the combination of leptin and forskolin. Colforsin 145-154 mitogen-activated protein kinase 3 Homo sapiens 173-179 19022848-6 2009 The activation of the ERK1/2 and Akt pathways as well as the expression of EGFR was stimulated by reagents that elevate intracellular cAMP levels, via cAMP analog 8-bromo-cAMP and AC activator forskolin. Colforsin 193-202 mitogen-activated protein kinase 3 Homo sapiens 22-28 19176384-11 2009 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin 35-44 mitogen-activated protein kinase 3 Homo sapiens 158-164 12727988-2 2003 In the present work we demonstrate that highly luteinized human granulosa cells obtained from in vitro fertilization patients respond to human LH as well as to forskolin in phosphorylation of extracellular-signal regulated kinases 1 and 2 (ERK1 and -2). Colforsin 160-169 mitogen-activated protein kinase 3 Homo sapiens 240-251 17565009-11 2007 Overexpression of Epac1 enhanced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation, whereas response to VEGF was unaffected. Colforsin 54-63 mitogen-activated protein kinase 3 Homo sapiens 72-78 17565009-12 2007 Inhibition of Epac1 expression with small interfering RNA substantially reduced A(2B)AR-mediated and forskolin-induced ERK1/2 phosphorylation and abolished that by 8CPT-2Me-cAMP. Colforsin 101-110 mitogen-activated protein kinase 3 Homo sapiens 119-125 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 106-112 16959941-7 2006 Forskolin or isoproterenol treatment blocked the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) induced by TGF-beta despite the fact that these cAMP-elevating agents stimulated ERK1/2 activation on their own. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 195-201 16644915-2 2006 We found that forskolin/IBMX also activate ERK1/2 phosphorylation in intestinal and pancreatic proglucagon-producing cell lines. Colforsin 14-23 mitogen-activated protein kinase 3 Homo sapiens 43-49 16644915-5 2006 Forskolin could activate ERK1/2 phosphorylation and proglucagon gene transcription on its own, whereas forskolin plus IBMX are required to effectively activate the PKA pathway in the proglucagon-producing cells. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 25-31 12970327-5 2003 HES cells express functional EP4 (with absence of expression of EP1, EP2, and EP3) receptors and stimulate cAMP release and rapid phosphorylation of ERK1/2 proteins in response to PGE(2) or forskolin. Colforsin 190-199 mitogen-activated protein kinase 3 Homo sapiens 149-155 15138589-8 2004 By contrast, we found that isoproterenol had no effect on A549 cells whereas forskolin significantly inhibited DNA synthesis and ERK1/2 activity. Colforsin 77-86 mitogen-activated protein kinase 3 Homo sapiens 129-135 12812976-8 2003 There was a greater rate of growth in mutant cells; forskolin and isoproterenol inhibited LPA-induced ERK1/2 phosphorylation in normal but not in mutant cells. Colforsin 52-61 mitogen-activated protein kinase 3 Homo sapiens 102-108 12812976-11 2003 We conclude that PKA activity in CNC cells is increased and that its stimulation by forskolin or isoproterenol increases LPA-induced ERK1/2 phosphorylation, cell metabolism and proliferation. Colforsin 84-93 mitogen-activated protein kinase 3 Homo sapiens 133-139 34606419-7 2021 Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. Colforsin 30-39 mitogen-activated protein kinase 3 Homo sapiens 80-86 11861509-2 2002 Human LH (hLH), hCG, and agents that indirectly elevate cAMP [cholera toxin, forskolin, (Bu)(2)cAMP], time- and dose-dependently activated ERK1/2 in hGL cells. Colforsin 77-86 mitogen-activated protein kinase 3 Homo sapiens 139-145 11861509-5 2002 In contrast, both inhibitors blocked cholera toxin-, forskolin-, and (Bu)(2)cAMP-induced ERK1/2 phosphorylation concomitant with a reduction in progesterone secretion. Colforsin 53-62 mitogen-activated protein kinase 3 Homo sapiens 89-95 11495722-6 2001 Interestingly, an increase of intracellular cAMP level with forskolin or 8-(4-chlorophenylthio)-cAMP augmented ERK1/2 phosphorylation by H(2)O(2), while inhibiting MEK1/2 phosphorylation by H(2)O(2). Colforsin 60-69 mitogen-activated protein kinase 3 Homo sapiens 111-117 9595434-13 1998 The effects of ISO and forskolin on attenuating ET-1-stimulated MAPK activity could be reversed by treating cells with H89, an inhibitor of protein kinase A. Colforsin 23-32 mitogen-activated protein kinase 3 Homo sapiens 64-68 10770951-4 2000 Forskolin induced Erk1/2 activation similarly to beta(3) activation, indicating cAMP-mediation; this induction could be inhibited with H89, implying protein kinase A mediation. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 18-24 7588214-5 1995 FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC-stimulated tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) as well as inhibited PKC-stimulated MAPK and Raf-1 activities. Colforsin 0-3 mitogen-activated protein kinase 3 Homo sapiens 149-156 7588214-5 1995 FSK treatment of osteoblasts, which raised intracellular cAMP levels and inhibited DNA synthesis, blocked PKC-stimulated tyrosine phosphorylation of p44mapk (ERK1) and p42mapk (ERK2) as well as inhibited PKC-stimulated MAPK and Raf-1 activities. Colforsin 0-3 mitogen-activated protein kinase 3 Homo sapiens 158-162 34606419-7 2021 Of note, we demonstrated that forskolin induced a decrease of p-C-Raf, p-MEK, p-ERK1/2 and p-p90Rsk, and an increase of p-PERK, p-eIF2alpha and CHOP, which indicated that the inhibition of Raf/MEK/ERK pathway and activation of PERK/eIF2alpha/CHOP pathway were involved, at least partially, in forskolin-induced MM.1S cells apoptosis. Colforsin 293-302 mitogen-activated protein kinase 3 Homo sapiens 80-86 29574069-0 2018 Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition. Colforsin 0-9 mitogen-activated protein kinase 3 Homo sapiens 115-121 33260669-0 2020 Essential Oils of Alpinia nantoensis Retard Forskolin-Induced Melanogenesis via ERK1/2-Mediated Proteasomal Degradation of MITF. Colforsin 44-53 mitogen-activated protein kinase 3 Homo sapiens 80-86 29574069-10 2018 It is important to note that the forskolin-induced potentiation of sensitivity to doxorubicin is accompanied by a strong inhibition of ERK1/2 phosphorylation, is mimicked by ERK inhibitor PD98059 and is prevented by pre-treatment with Protein Kinase A (PKA) and adenylate cyclase inhibitors. Colforsin 33-42 mitogen-activated protein kinase 3 Homo sapiens 135-141 28106114-6 2017 Under these conditions the subsequent Forskolin-induced cAMP release reverses the transient increase of EGF-mediated ERK1&2 kinase activity while reinforcing PKA activation. Colforsin 38-47 mitogen-activated protein kinase 3 Homo sapiens 117-121 28222855-13 2017 Treatment of both Panc-1 and MIA PaCa-2 cells with forskolin/IBMX decreased ERK1/2 phosphorylation. Colforsin 51-60 mitogen-activated protein kinase 3 Homo sapiens 76-82