PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 127-131 20451507-5 2010 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that the drug increased levels of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 146-150 21977288-7 2010 Activation of PKA by forskolin or PKC by PMA resulted in a level of CREB phosphorylation comparable to the reduced level of the strain-induced CREB phosphorylation in the presence of PKA or PKC inhibitors. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 68-72 20063885-5 2010 In the presence of Ap, forskolin, or both, the expression of phospho-cAMP response element-binding protein (CREB) was increased. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 61-106 20063885-5 2010 In the presence of Ap, forskolin, or both, the expression of phospho-cAMP response element-binding protein (CREB) was increased. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 108-112 17925456-6 2007 Expression of a dominant-negative form of CREB (MCREB), which was effective in suppressing CRE-mediated transcription induced by the adenylate cyclase activator forskolin, inhibited basal and forskolin-induced PRL promoter activity and PRL mRNA expression. Colforsin 161-170 cAMP responsive element binding protein 1 Rattus norvegicus 42-46 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 cAMP responsive element binding protein 1 Rattus norvegicus 60-64 20022930-9 2010 Transient transfection of ATF6 inhibited transactivation by CREB on the PEPCK and G6Pase promoters, and a gel shift assay showed that Ad-ATF6 inhibits forskolin-stimulated CREB DNA-binding activity. Colforsin 151-160 cAMP responsive element binding protein 1 Rattus norvegicus 172-176 17925456-6 2007 Expression of a dominant-negative form of CREB (MCREB), which was effective in suppressing CRE-mediated transcription induced by the adenylate cyclase activator forskolin, inhibited basal and forskolin-induced PRL promoter activity and PRL mRNA expression. Colforsin 192-201 cAMP responsive element binding protein 1 Rattus norvegicus 42-46 16641242-4 2006 At the cellular level, CREBGFP expression in the LC in vivo and in vitro had no significant effect on neuronal firing at baseline but enhanced the excitatory effect of forskolin (an activator of adenylyl cyclase) on these neurons, which suggests that the cAMP signaling pathway in these neurons was sensitized after CREB expression. Colforsin 168-177 cAMP responsive element binding protein 1 Rattus norvegicus 23-27 16322355-5 2006 Intra-accumbal injections of forskolin, an adenylyl cyclase activator, stimulated the phosphorylation of CREB and increased both CART mRNA and peptide levels, an effect attenuated by inhibition of PKA with H89 [N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinoline-sulfonamide hydrochloride] and adenosine-3",5"-cyclic monophosphorothioate, Rp-isomer (Rp-cAMPS). Colforsin 29-38 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 19003050-4 2005 siRNA-mediated reduction of the expression of PLCgamma2, but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB-dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca(2+), respectively. Colforsin 212-221 cAMP responsive element binding protein 1 Rattus norvegicus 114-118 16043122-6 2005 CREB was activated by forskolin (10 microM), PMA (500 nM), and cyclical mechanical strain (1 Hz, 5% elongation) in fibroblasts. Colforsin 22-31 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 19003050-4 2005 siRNA-mediated reduction of the expression of PLCgamma2, but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB-dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca(2+), respectively. Colforsin 212-221 cAMP responsive element binding protein 1 Rattus norvegicus 149-153 12421622-6 2002 Cortical cultures treated with glutamate, forskolin or the phorbol ester phorbol 12-myristate 13-acetate exhibited robust increases in phospho-CREB. Colforsin 42-51 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 15730866-6 2005 An increase in cAMP by forskolin resulted in a persistent, uniform increase of the phosphorylated CREB (pCREB/CREB immunofluorescence ratio) in all hippocampal principal neurons. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 98-102 15730866-6 2005 An increase in cAMP by forskolin resulted in a persistent, uniform increase of the phosphorylated CREB (pCREB/CREB immunofluorescence ratio) in all hippocampal principal neurons. Colforsin 23-32 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 30-39 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 cAMP responsive element binding protein 1 Rattus norvegicus 0-4 14645671-7 2003 CREB was phosphorylated after forskolin induction, and both CREB and CREB-binding protein (CBP) binding to the endogenous MOR promoter was increased by forskolin in chromatin immunoprecipitation assay. Colforsin 152-161 cAMP responsive element binding protein 1 Rattus norvegicus 60-64 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 23-27 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 133-137 14645671-8 2003 The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction. Colforsin 165-174 cAMP responsive element binding protein 1 Rattus norvegicus 133-137 12117553-4 2002 Western blotting showed that incubation of GH3 cells with forskolin, which enhances CART mRNA expression, caused an increase in phosphorylated CREB (P-CREB) levels. Colforsin 58-67 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 12117553-4 2002 Western blotting showed that incubation of GH3 cells with forskolin, which enhances CART mRNA expression, caused an increase in phosphorylated CREB (P-CREB) levels. Colforsin 58-67 cAMP responsive element binding protein 1 Rattus norvegicus 151-155 12969258-5 2003 Precipitated morphine withdrawal was associated with enhanced dopamine-, SKF 82958 (D1 receptor agonist)-, and forskolin-induced CREB phosphorylation. Colforsin 111-120 cAMP responsive element binding protein 1 Rattus norvegicus 129-133 12021190-9 2002 Treatment with FSH (0.9 IU/ml) or forskolin for 20 min increased CREB phosphorylation, but had little effect on AKT phosphorylation. Colforsin 34-43 cAMP responsive element binding protein 1 Rattus norvegicus 65-69 11923475-7 2002 This promoter showed the strong activity in the pituitary-derived GH4C1 cells, and the region between -697 and -596 bp was responsible for the stimulation both by forskolin and overexpression of cAMP response element binding protein (CREB). Colforsin 163-172 cAMP responsive element binding protein 1 Rattus norvegicus 234-238 11567621-5 2001 Tetanus and forskolin-induced activation of mitogen-activated protein kinase (MAPK) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein (CREB) phosphorylation. Colforsin 12-21 cAMP responsive element binding protein 1 Rattus norvegicus 144-181 11567621-5 2001 Tetanus and forskolin-induced activation of mitogen-activated protein kinase (MAPK) was blocked by PI-3 kinase inhibitors, which also inhibited cAMP response element binding protein (CREB) phosphorylation. Colforsin 12-21 cAMP responsive element binding protein 1 Rattus norvegicus 183-187 11113530-7 2000 Dexamethasone (DEX; 1 microM) further enhanced FSK- or PMA-induced proENK mRNA expression, which was not correlated with the activation of AP-1 expression and CREB phosphorylation, suggesting that synergistic interaction of glucocorticoid with PKA or PKC pathway for the regulation of proENK mRNA expression appears to be mediated by other pathways rather than CREB and AP-1 families. Colforsin 47-50 cAMP responsive element binding protein 1 Rattus norvegicus 361-365 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 cAMP responsive element binding protein 1 Rattus norvegicus 142-185 11353815-4 2001 Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB). Colforsin 15-24 cAMP responsive element binding protein 1 Rattus norvegicus 187-191 11353815-10 2001 Forskolin-stimulated CGRP release and CREB phosphorylation could be mimicked by incubation of the cells with chlorophenylthio-cAMP and blocked by pretreatment with the PKA inhibitor myrPKI(14-22). Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 38-42 11113530-2 2000 FSK-induced proENK mRNA expression is independent of protein de novo synthesis, and well correlated with CREB phosphorylation. Colforsin 0-3 cAMP responsive element binding protein 1 Rattus norvegicus 105-109 11113530-6 2000 The combined treatment with FSK and PMA additively increased the proENK mRNA level, which was correlated with AP-1 or ENKCRE-2 DNA binding activity, and CREB phosphorylation. Colforsin 28-31 cAMP responsive element binding protein 1 Rattus norvegicus 153-157 10908723-3 2000 Whilst the protein kinase A inhibitor H89 ablated the ability of forskolin to cause cAMP response element binding protein (CREB) phosphorylation in Rat1 cells, it did not affect the ability of forskolin to activate either Rap1A and Rap1B. Colforsin 65-74 cAMP responsive element binding protein 1 Rattus norvegicus 84-121 11108142-2 2000 To test whether the transcription factor CREB is in the pathway involved in modulation of AT1-receptor gene expression, AT1 receptor mRNA levels were measured after stimulation with forskolin, angiotensin II and PDGF-BB in VSMC expressing the inducible cAMP early repressor protein, ICERIIgamma, fused to the green fluorescent protein (eGFP). Colforsin 182-191 cAMP responsive element binding protein 1 Rattus norvegicus 41-45 10908723-3 2000 Whilst the protein kinase A inhibitor H89 ablated the ability of forskolin to cause cAMP response element binding protein (CREB) phosphorylation in Rat1 cells, it did not affect the ability of forskolin to activate either Rap1A and Rap1B. Colforsin 65-74 cAMP responsive element binding protein 1 Rattus norvegicus 123-127 10446909-4 1999 However, granulosa cells expressing CREB M1, but not adenovirus-directed beta-galactosidase or enhanced green fluorescent protein, exhibited a 35% reduction in viability that was further reduced to 65% after stimulation with 10 microM forskolin. Colforsin 235-244 cAMP responsive element binding protein 1 Rattus norvegicus 36-40 10849656-11 2000 Thus, the mechanism by which hypoxia regulates CREB is distinct, and more complex, than that induced by forskolin, depolarization, or nerve growth factor. Colforsin 104-113 cAMP responsive element binding protein 1 Rattus norvegicus 47-51 10446906-12 1999 Aromatase, Sgk, and phospho-CREB were expressed at elevated levels in a non-forskolin-responsive manner. Colforsin 76-85 cAMP responsive element binding protein 1 Rattus norvegicus 28-32 10588574-6 1999 This seemed to be a direct effect because H2O2 also inhibited CREB phosphorylation induced by the adenylyl cyclase stimulator forskolin. Colforsin 126-135 cAMP responsive element binding protein 1 Rattus norvegicus 62-66 9447994-7 1998 A-CREB inhibited activation of CRE-mediated transcription evoked by three distinct stimuli: forskolin, which increases intracellular cAMP; membrane depolarization, which promotes Ca2+ influx; and nerve growth factor (NGF). Colforsin 92-101 cAMP responsive element binding protein 1 Rattus norvegicus 2-6 9677418-3 1998 Hypoxia-induced phosphorylation of CREB was more robust than that induced by any other stimulus tested, including forskolin, depolarization, and osmotic stress. Colforsin 114-123 cAMP responsive element binding protein 1 Rattus norvegicus 35-39 7628390-3 1995 Here we show that the addition of forskolin to cultured primary Sertoli cells results in the phosphorylation of CREB within 2-5 min. Colforsin 34-43 cAMP responsive element binding protein 1 Rattus norvegicus 112-116 8620554-5 1996 The differential responsiveness of CREB to forskolin in PC12 cells and BAL-17 B cells may relate to the more marked elevation of cAMP in the former as opposed to the latter; however, high concentrations of dbcAMP which should readily enter B cells and artificially increase cAMP levels still failed to induce CREB Ser133 phosphorylation, even in conjunction with a phosphodiesterase inhibitor. Colforsin 43-52 cAMP responsive element binding protein 1 Rattus norvegicus 35-39 7628390-4 1995 Phospho-CREB levels remain elevated with continued forskolin stimulation, but fall by 60% within 5 min after the removal of forskolin. Colforsin 51-60 cAMP responsive element binding protein 1 Rattus norvegicus 8-12 7628390-4 1995 Phospho-CREB levels remain elevated with continued forskolin stimulation, but fall by 60% within 5 min after the removal of forskolin. Colforsin 124-133 cAMP responsive element binding protein 1 Rattus norvegicus 8-12 27823935-8 2016 The protein kinase A (PKA) inhibitor H89 and the inactivation of cAMP response element-binding protein (CREB) suppressed forskolin-stimulated CART mRNA expression. Colforsin 121-130 cAMP responsive element binding protein 1 Rattus norvegicus 65-102 7731990-9 1995 Transfection assays in PC12 cells with the CREB-dependent somatostatin promoter demonstrate a nearly 15-fold transcriptional induction after forskolin stimulation in the presence of pX. Colforsin 141-150 cAMP responsive element binding protein 1 Rattus norvegicus 43-47 7919167-4 1994 Although forskolin did not alter CREB-IR, forskolin did induce striatal P-CREB-IR and Fos-IR by 2.5- and 10-fold, respectively. Colforsin 42-51 cAMP responsive element binding protein 1 Rattus norvegicus 74-78 1352481-1 1992 We have examined the mechanism by which the transcriptional activity of the cAMP-responsive factor CREB is attenuated following induction with forskolin. Colforsin 143-152 cAMP responsive element binding protein 1 Rattus norvegicus 99-103 2573431-1 1989 In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12 cells with forskolin. Colforsin 136-145 cAMP responsive element binding protein 1 Rattus norvegicus 54-58 32286359-1 2020 Forskolin promotes neuronal differentiation of PC12 cells via the PKA-CREB-dependent signaling pathway. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 70-74 32286359-2 2020 Activation of PKA by forskolin phosphorylates CREB, which then binds to CRE sites in numerous gene promoters. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 46-50 32286359-7 2020 We also revealed that the specific four CRE sites near the transcriptional start site (TSS) of nur77 were strongly associated with phosphorylated CREB within 1 hr after treatment with forskolin. Colforsin 184-193 cAMP responsive element binding protein 1 Rattus norvegicus 146-150 32286359-10 2020 An analysis of neuronal markers controlled by Nur77 after A-CREB-Nur77-Synapsin1 signaling pathway plays a pivotal role in differentiation of forskolin-induced PC12 cells. Colforsin 142-151 cAMP responsive element binding protein 1 Rattus norvegicus 60-64 28216156-5 2017 In contrast, forskolin-induced phosphorylation of CREB was unaffected by Epac inhibition. Colforsin 13-22 cAMP responsive element binding protein 1 Rattus norvegicus 50-54 7919167-0 1994 Forskolin increases phosphorylated-CREB and fos immunoreactivity in rat striatum. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 35-39 27823935-8 2016 The protein kinase A (PKA) inhibitor H89 and the inactivation of cAMP response element-binding protein (CREB) suppressed forskolin-stimulated CART mRNA expression. Colforsin 121-130 cAMP responsive element binding protein 1 Rattus norvegicus 104-108 23292070-7 2013 Sirt1 activation and overexpression suppressed forskolin-induced CREB-Ser(133) phosphorylation, but no effect was seen with vehicle and empty plasmid controls. Colforsin 47-56 cAMP responsive element binding protein 1 Rattus norvegicus 65-69 26268270-6 2015 Forskolin-induced increases in cAMP and renin expression were prevented by calphostin C. PKC inhibition and Ca2+ depletion impaired ANG II-mediated CREB phosphorylation and upregulation of renin. Colforsin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 148-152 27840939-6 2016 Treatment with the cAMP-elevating agent, forskolin stimulated CREB-1 phosphorylation and transcription activation in HSCs. Colforsin 41-50 cAMP responsive element binding protein 1 Rattus norvegicus 62-66 24833716-8 2014 Finally, forskolin induces Sh3tc2 expression in rat primary Schwann cells, indicating that SH3TC2 is a CREB target gene. Colforsin 9-18 cAMP responsive element binding protein 1 Rattus norvegicus 103-107 22509362-7 2012 In contrast, when islets were grown in 5 mM (low) glucose, CREB was transiently activated in response to glucose or forskolin stimuli. Colforsin 116-125 cAMP responsive element binding protein 1 Rattus norvegicus 59-63 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 67-71 21991573-7 2011 After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. Colforsin 21-30 cAMP responsive element binding protein 1 Rattus norvegicus 118-122 21991573-8 2011 CONCLUSION: Both H89 (PKA inhibitor) and forskolin (cAMP inducing medicine) regulate AQP5 production through the cAMP-PKA/CREB pathway, which could influence the secretory function of the submucosal glands in nasal epithelium. Colforsin 41-50 cAMP responsive element binding protein 1 Rattus norvegicus 122-126 20688914-3 2010 Deletion analysis of phosphoenolpyruvate carboxykinase (PEPCK) promoter demonstrated that SHP inhibited forskolin-mediated induction of PEPCK gene transcription via inhibition of CREB transcriptional activity. Colforsin 104-113 cAMP responsive element binding protein 1 Rattus norvegicus 179-183