PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 26-29 23581627-10 2014 In addition, NaHS treatment also inhibited forskolin-induced renin degranulation from HMC-1.1 mast cells by lowering intracellular cAMP level. Colforsin 43-52 renin Homo sapiens 61-66 19564544-5 2009 The adenylyl cyclase activator forskolin, the cAMP analogue 8-db-cAMP, and the degranulator compound 48/80 increased renin release without affecting prorenin. Colforsin 31-40 renin Homo sapiens 117-122 19564544-6 2009 Angiotensin II blocked the forskolin-induced renin release. Colforsin 27-36 renin Homo sapiens 45-50 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 18981317-7 2008 Blockade of cell lysate renin activity ranged from 27+/-15% to 79+/-5%, and these percentages were identical for the renin that was released by forskolin, indicating that they represented the same renin pool, ie, the renin storage granules. Colforsin 144-153 renin Homo sapiens 117-122 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 131-134 12933794-7 2003 Forskolin, which augments REN mRNA stability in Calu-6 cells, increased binding of several proteins, including HuR and CP1, to the REN 3"-UTR, whereas 4-bromocrotonic acid, a specific thiolase inhibitor, decreased binding and elevated renin protein levels. Colforsin 0-9 renin Homo sapiens 235-240 12600897-7 2003 Forskolin, an activator of cAMP synthesis, considerably stimulates renin synthesis via inhibition of REN mRNA decay. Colforsin 0-9 renin Homo sapiens 67-72 12600897-7 2003 Forskolin, an activator of cAMP synthesis, considerably stimulates renin synthesis via inhibition of REN mRNA decay. Colforsin 0-9 renin Homo sapiens 101-104 9256163-4 1997 Forskolin (10 microM), an activator of adenylyl cyclase, and terbutaline (100 microM), a beta2-adrenergic agonist known to increase cAMP levels, also increased renin mRNA and prorenin release. Colforsin 0-9 renin Homo sapiens 160-165 10082506-6 1999 Experiments with both actinomycin D and 5, 6-dichlororibofuranosylbenzimidazole (DRB) showed that forskolin treatment markedly stabilized hREN mRNA in Calu-6 cells. Colforsin 98-107 renin Homo sapiens 138-142 10082506-8 1999 Experiments with DRB demonstrated a similar robust stabilization of hREN mRNA after forskolin and phorbol ester treatment. Colforsin 84-93 renin Homo sapiens 68-72 9294125-7 1997 By contrast, renin secretion from CaLu-6 cells comprised approximately 30% of cellular stores, yet was also stimulated twofold by 10 microM forskolin (P </= 0.001). Colforsin 140-149 renin Homo sapiens 13-18 9294125-8 1997 In JG cells, mechanical stretch inhibited basal renin release by 42% (P < 0.01) and forskolin-stimulated renin release by 25% (P < 0.05). Colforsin 87-96 renin Homo sapiens 108-113 9294125-9 1997 In CaLu-6 cells, stretch inhibited basal- and forskolin-stimulated renin release by 30 and 26%, respectively (both P < 0.01). Colforsin 46-55 renin Homo sapiens 67-72 9853270-5 1998 Regulation of the hREN promoter activity was investigated using Y-1 adrenal cells that were transfected with the hREN-luciferase DNA and were treated with forskolin, calcium ionophore A23187, phorbol ester, angiotensin II (Ang II), or cytokines. Colforsin 155-164 renin Homo sapiens 18-22 7637256-2 1995 We found that forskolin (3 microM), an activator of adenylate cyclase led to proportional increases of renin secretion and renin mRNA levels. Colforsin 14-23 renin Homo sapiens 103-108 8760248-4 1996 Treating Calu-6 cells with forskolin caused a 100-fold increase in steady-state endogenous hREN mRNA but no increase in hREN promoter activity in transient transfections or in nuclear runoff transcription assays. Colforsin 27-36 renin Homo sapiens 91-95 8999953-4 1997 Forskolin treatment alone only caused a 2-3-fold activation of the HREN promoter in Calu-6 cells, but nearly a 10-fold activation in JEG-3 cells, which do not express renin but are highly responsive to cAMP. Colforsin 0-9 renin Homo sapiens 167-172 7637256-2 1995 We found that forskolin (3 microM), an activator of adenylate cyclase led to proportional increases of renin secretion and renin mRNA levels. Colforsin 14-23 renin Homo sapiens 123-128 8184901-2 1994 Isoproterenol and forskolin increased intracellular adenosine 3",5"-cyclic monophosphate (cAMP) concentration and stimulated renin secretion as did the addition of dibutyryl-cAMP. Colforsin 18-27 renin Homo sapiens 125-130 7699994-9 1994 Evidence suggests that forskolin-responsive signal transduction pathways may lead cyclic AMP responsive element (CRE) binding protein (CREB) to act on a CRE at -222 in the proximal REN promoter DNA. Colforsin 23-32 renin Homo sapiens 181-184 7997449-4 1994 We found that cholera toxin and forskolin markedly stimulate the synthesis and release of renin in a time-dependent manner. Colforsin 32-41 renin Homo sapiens 90-95 7997449-7 1994 The potential for stimulation of renin expression by cyclic AMP-regulated elements is supported by the dramatic (two-orders of magnitude) increase in renin release observed with cholera and forskolin at 72 h. There are several possible candidates for primary signals for adenylyl cyclase-coupled renin secretion from the placenta, including relaxin and epinephrine. Colforsin 190-199 renin Homo sapiens 33-38 7997449-7 1994 The potential for stimulation of renin expression by cyclic AMP-regulated elements is supported by the dramatic (two-orders of magnitude) increase in renin release observed with cholera and forskolin at 72 h. There are several possible candidates for primary signals for adenylyl cyclase-coupled renin secretion from the placenta, including relaxin and epinephrine. Colforsin 190-199 renin Homo sapiens 150-155 7997449-7 1994 The potential for stimulation of renin expression by cyclic AMP-regulated elements is supported by the dramatic (two-orders of magnitude) increase in renin release observed with cholera and forskolin at 72 h. There are several possible candidates for primary signals for adenylyl cyclase-coupled renin secretion from the placenta, including relaxin and epinephrine. Colforsin 190-199 renin Homo sapiens 150-155 8156625-12 1994 Finally, luciferase analysis of 5"-deletion mutant revealed that -273 to +16 bp of the renin promoter was sufficient to confer complete forskolin stimulation, whereas deletion to -130 (deletion of the CRE) decreased cAMP responsiveness by 50% and those to -67 bp (deletion of the CRE and Pit-1-like sequences) suppressed it. Colforsin 136-145 renin Homo sapiens 87-92 7721420-8 1995 Human renin expression in these cells was induced approximately 100-fold after treatment with forskolin, 8-bromoadenosine 3":5"-cyclic monophosphate, or N6,2"-O-dibutyryladenosine 3":5"-cyclic monophosphate. Colforsin 94-103 renin Homo sapiens 6-11 7961740-3 1994 In the present study we examine the effects of forskolin and T3 on the expression of luciferase hybrid genes containing hREN 5"-flanking DNAs (hREN.luc) transiently transfected into the pituitary cell line GC. Colforsin 47-56 renin Homo sapiens 120-124 7961740-3 1994 In the present study we examine the effects of forskolin and T3 on the expression of luciferase hybrid genes containing hREN 5"-flanking DNAs (hREN.luc) transiently transfected into the pituitary cell line GC. Colforsin 47-56 renin Homo sapiens 143-147 7961740-5 1994 Addition of forskolin stimulated expression up to 48-fold, depending on the hREN sequences present. Colforsin 12-21 renin Homo sapiens 76-80 7961740-6 1994 The hREN sequence -148 to +18 was sufficient for both maximal expression and maximal stimulation by forskolin. Colforsin 100-109 renin Homo sapiens 4-8 2822309-9 1987 Forskolin (10 mumol/l for 24 h) increased secretion of renin from 1.9 +/- 0.36 to 4.1 +/- 0.64 pg/ml per h of culture (P less than 0.001, n = 11), consistent with cAMP being a second messenger in the secretory mechanism. Colforsin 0-9 renin Homo sapiens 55-60 1317905-1 1992 Comparison with forskolin-induced renin secretion. Colforsin 16-25 renin Homo sapiens 34-39 1317905-2 1992 OBJECTIVE: Renin secretion in response to long-term exposure to isoprenaline, dibutyryl cyclic adenosine monophosphate (dbcAMP), forskolin and atrial natriuretic peptide (ANP) was measured in cultured human nephroblastoma cells. Colforsin 129-138 renin Homo sapiens 11-16 1317905-6 1992 Forskolin stimulated renin secretion per cell. Colforsin 0-9 renin Homo sapiens 21-26 1317905-9 1992 ANP suppressed isoprenaline-induced and dbcAMP-induced renin output by blocking increased cell growth, and forskolin-induced renin output by blocking renin secretion. Colforsin 107-116 renin Homo sapiens 125-130 1317905-9 1992 ANP suppressed isoprenaline-induced and dbcAMP-induced renin output by blocking increased cell growth, and forskolin-induced renin output by blocking renin secretion. Colforsin 107-116 renin Homo sapiens 125-130 1587805-3 1992 The secretion of active renin was stimulated by forskolin, and the stimulation was repressed by dexamethasone. Colforsin 48-57 renin Homo sapiens 24-29 1587805-5 1992 Moreover, the forskolin-stimulated release of active renin was hardly repressed by dexamethasone in AtT-20 cells transfected with the renin expression plasmid and a selectable plasmid pMAMneo. Colforsin 14-23 renin Homo sapiens 53-58 1587805-5 1992 Moreover, the forskolin-stimulated release of active renin was hardly repressed by dexamethasone in AtT-20 cells transfected with the renin expression plasmid and a selectable plasmid pMAMneo. Colforsin 14-23 renin Homo sapiens 134-139 1745821-15 1991 By contrast, cAMP induces in essence gene activation in WI26VA4 transformed human lung fibroblasts in which renin mRNA levels increase by up to 150-fold in response to forskolin. Colforsin 168-177 renin Homo sapiens 108-113 2217188-4 1990 Treatment of the cultures with a calcium ionophore alone, calcium ionophore plus forskolin (that activates adenylate cyclase), or forskolin plus a phorbol ester increased prorenin release and renin mRNA levels 1.3- to 6-fold, but several classes of steroids did not affect prorenin secretion or renin RNA levels. Colforsin 81-90 renin Homo sapiens 174-179 2217188-4 1990 Treatment of the cultures with a calcium ionophore alone, calcium ionophore plus forskolin (that activates adenylate cyclase), or forskolin plus a phorbol ester increased prorenin release and renin mRNA levels 1.3- to 6-fold, but several classes of steroids did not affect prorenin secretion or renin RNA levels. Colforsin 81-90 renin Homo sapiens 192-197 2217188-4 1990 Treatment of the cultures with a calcium ionophore alone, calcium ionophore plus forskolin (that activates adenylate cyclase), or forskolin plus a phorbol ester increased prorenin release and renin mRNA levels 1.3- to 6-fold, but several classes of steroids did not affect prorenin secretion or renin RNA levels. Colforsin 130-139 renin Homo sapiens 174-179 2217188-4 1990 Treatment of the cultures with a calcium ionophore alone, calcium ionophore plus forskolin (that activates adenylate cyclase), or forskolin plus a phorbol ester increased prorenin release and renin mRNA levels 1.3- to 6-fold, but several classes of steroids did not affect prorenin secretion or renin RNA levels. Colforsin 130-139 renin Homo sapiens 192-197 2217188-5 1990 The transfected renin promoter (584 or 100 base pairs of 5"-flanking DNA) initiated at the correct start site in these cells and forskolin increased its expression 2.5- to 4-fold. Colforsin 129-138 renin Homo sapiens 16-21 8391804-4 1993 PMA and forskolin acted synergistically to increase both renin mRNA levels and renin production in a dose-dependent manner. Colforsin 8-17 renin Homo sapiens 57-62 8391804-4 1993 PMA and forskolin acted synergistically to increase both renin mRNA levels and renin production in a dose-dependent manner. Colforsin 8-17 renin Homo sapiens 79-84 3039094-7 1986 Forskolin induced renin secretion in a dose-dependent manner, as did dibutyryl cAMP. Colforsin 0-9 renin Homo sapiens 18-23