PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10198333-7 1999 Atropine significantly attenuated gastrin increase at 30 min by 26%. Atropine 0-8 gastrin Rattus norvegicus 34-41 10961714-7 2000 Likewise, the acid response to peptone was also markedly enhanced in STZ-diabetic rats, and this response was significantly blocked by atropine and YM022 (a CCKB/gastrin antagonist) as well as famotidine in both normal and diabetic rats. Atropine 135-143 gastrin Rattus norvegicus 162-169 8795088-8 1996 In this study, 2 ng of oxytocin decreased plasma levels of CCK, gastrin and somatostatin, effects that were blocked by pretreatment with atropine. Atropine 137-145 gastrin Rattus norvegicus 64-71 9468094-5 1998 The gastrin and somatostatin responses to 10(-4) M GABA were completely inhibited by the GABA(A) antagonist bicuculline (10(-5) M) and the cholinergic blocker atropine(l0(-7) M), whereas the GABAB antagonist CGP 35348 (5 x 10(-5) M) was ineffective. Atropine 159-167 gastrin Rattus norvegicus 4-11 9163580-6 1997 A contribution of cholinergic mechanisms to this vagovagal-mediated stimulation of distention-induced gastrin release was excluded, since atropine (100 microg/kg/h; n = 8) further augmented distention-stimulated gastrin release. Atropine 138-146 gastrin Rattus norvegicus 212-219 9163580-10 1997 Distention-induced decrease of gastrin release was attenuated to 50 percent by atropine (10(-7) M: n = 10) or tetrodotoxin (TTX) (10(-6) M; n = 10), respectively. Atropine 79-87 gastrin Rattus norvegicus 31-38 7719401-5 1995 Tetrodotoxin and atropine sulfate completely inhibited this sodium taurocholate induced-gastrin increase, while truncal vagotomy was without effect. Atropine 17-33 gastrin Rattus norvegicus 88-95 8446002-5 1993 In contrast, atropine (10(-7) M) reduced significantly the gastrin response at 2 Hz (270 +/- 78 pg/10 min, p < 0.01), but not at 10 Hz (446 +/- 87 pg/10 min, p > 0.05). Atropine 13-21 gastrin Rattus norvegicus 59-66 7843261-6 1994 The degree and duration of anti-acid secretion by atropine sulfate were equal to those of cimetidine, but the elevation of gastrin release by atropine sulfate was weak and temporary. Atropine 142-158 gastrin Rattus norvegicus 123-130 8446002-6 1993 The combination of BN-antagonist and atropine elicited an inhibition of vagally stimulated gastrin release similar to each substance when given alone. Atropine 37-45 gastrin Rattus norvegicus 91-98 2875917-4 1986 Inclusion of either atropine or pirenzepine in incubation medium prevented GABA-induced stimulation of gastrin release and inhibition of somatostatin release. Atropine 20-28 gastrin Rattus norvegicus 103-110 1717355-9 1991 Oral administration of NIK-228 and atropine inhibited gastrin, 2-deoxy-D-glucose (2-DG) and bethanechol-induced acid secretion, but didn"t inhibit histamine-induced acid secretion. Atropine 35-43 gastrin Rattus norvegicus 54-61 2226784-2 1990 Carbachol induced an increase in intracellular Ca2+ and stimulated gastrin release in a dose-dependent manner over the range 10(-5)-10(-3) M. These effects were completely abolished by atropine, suggesting the implication of muscarinic cholinergic receptors. Atropine 185-193 gastrin Rattus norvegicus 67-74 1318089-6 1992 In contrast, the modest increase in plasma gastrin induced by gastric perfusion with NaHCO3 was completely suppressed by the high atropine dose and was attenuated by small doses of atropine or telenzepine (0.01 mumol/kg and 1 mumol/kg). Atropine 130-138 gastrin Rattus norvegicus 43-50 1318089-6 1992 In contrast, the modest increase in plasma gastrin induced by gastric perfusion with NaHCO3 was completely suppressed by the high atropine dose and was attenuated by small doses of atropine or telenzepine (0.01 mumol/kg and 1 mumol/kg). Atropine 181-189 gastrin Rattus norvegicus 43-50 1348906-4 1992 Atropine partly inhibited the gastrin response (50%) and converted the somatostatin response to an increase above basal level. Atropine 0-8 gastrin Rattus norvegicus 30-37 1348906-6 1992 A combination of atropine and the bombesin/GRP antagonist, like TTX, abolished the gastrin and somatostatin responses. Atropine 17-25 gastrin Rattus norvegicus 83-90 1699429-5 1990 Bilateral cervical vagotomy or atropine pretreatment prevented intracisternal RX 77368-induced rise in hepatic portal levels of histamine, whereas purified gastrin monoclonal antibody 9303, injected at a dose blocking gastrin-stimulated acid secretion, had no effect. Atropine 31-39 gastrin Rattus norvegicus 218-225 3596169-7 1987 In tissue culture, bombesin significantly stimulated gastrin and gastrin-G secretion at doses of 10(-8) and 3 X 10(-8) M. Atropine (10(-6) M) abolished the actions of carbachol to stimulate gastrin and gastrin-G secretion but had no effect on bombesin-stimulated gastrin and gastrin-G secretion. Atropine 122-130 gastrin Rattus norvegicus 53-60 2892415-5 1987 Atropine partially inhibited the gastrin response (34 +/- 6%) but had no effect on the somatostatin response. Atropine 0-8 gastrin Rattus norvegicus 33-40 2878856-3 1987 Four weeks of treatment evoked marked gastrin hypersecretion, which was atropine-resistant. Atropine 72-80 gastrin Rattus norvegicus 38-45 3614557-5 1987 Atropine reduced vagally stimulated gastrin levels substantially. Atropine 0-8 gastrin Rattus norvegicus 36-43 3596152-3 1987 Atropine 10(-6) M, which abolished the effects of cholinergic agent to stimulate gastrin secretion, blocked the 5-HT-stimulated gastrin and gastrin-G secretion. Atropine 0-8 gastrin Rattus norvegicus 81-88 3596152-3 1987 Atropine 10(-6) M, which abolished the effects of cholinergic agent to stimulate gastrin secretion, blocked the 5-HT-stimulated gastrin and gastrin-G secretion. Atropine 0-8 gastrin Rattus norvegicus 128-135 3596152-3 1987 Atropine 10(-6) M, which abolished the effects of cholinergic agent to stimulate gastrin secretion, blocked the 5-HT-stimulated gastrin and gastrin-G secretion. Atropine 0-8 gastrin Rattus norvegicus 128-135 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Atropine 92-100 gastrin Rattus norvegicus 0-7 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Atropine 92-100 gastrin Rattus norvegicus 186-193 3569746-2 1986 Gastrin secretion was significantly stimulated by exogenous bombesin at a dose of 10(-8) M. Atropine 10(-6) M, which abolished the action of the cholinergic agent carbachol to stimulate gastrin secretion, had no effect on bombesin-stimulated gastrin secretion. Atropine 92-100 gastrin Rattus norvegicus 242-249 6124477-3 1982 The gastrin response was abolished by hexamethonium but only partly inhibited (35% at the higher dose of 1,1-dimethyl-4-phenylpiperazinium) by atropine. Atropine 143-151 gastrin Rattus norvegicus 4-11 2881348-7 1986 On day 24, plasma gastrin was elevated more than 10-fold in both groups of rats treated with omeprazole but not in animals given atropine alone. Atropine 129-137 gastrin Rattus norvegicus 18-25 2857528-4 1985 Both atropine and pirenzepine reversed these effects in a dose-dependent fashion with D50 values of 1 X 10(-9) and 1 X 10(-7) M, respectively, against gastrin stimulation and 1 X 10(-8) and 1 X 10(-7) M, respectively, against SLI inhibition. Atropine 5-13 gastrin Rattus norvegicus 151-158 6146551-5 1984 These neurons were both cholinergic and noncholinergic, because addition of an optimal dose of atropine (10(-7) M) to the vascular perfusate inhibited only partially the gastrin response and converted the somatostatin response from decrease below basal levels--a typical cholinergic effect--to significant increase above basal levels. Atropine 95-103 gastrin Rattus norvegicus 170-177 6146551-6 1984 As shown previously, atropine had an identical effect on gastrin and somatostatin responses to transmural electrical stimulation of the antral region. Atropine 21-29 gastrin Rattus norvegicus 57-64 6146189-9 1984 In rats, low doses of atropine (0.05 mg/kg) completely inhibits the intragastric vagally mediated release of somatostatin, which leads to an approximately 10-fold enhancement of the simultaneously occurring gastrin release. Atropine 22-30 gastrin Rattus norvegicus 207-214 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Atropine 267-275 gastrin Rattus norvegicus 0-7 2877911-1 1986 Gastrin release was significantly stimulated by the cholinergic agent carbachol at doses of 10(-4) M, 10(-5) M, and 10(-6) M. Peak stimulation was observed at 10(-5) M. Gastrin release was also significantly stimulated by bombesin at a dose of 10(-8) M, and 10(-6) M atropine which abolished the effect of carbachol in stimulating gastrin release had no effect on the bombesin-stimulated gastrin release. Atropine 267-275 gastrin Rattus norvegicus 169-176 6128924-3 1982 Stimulation at increasing cycle durations (0.1-4 ms) caused increasing gastrin secretion that was progressively more resistant to atropine. Atropine 130-138 gastrin Rattus norvegicus 71-78 6124477-4 1982 The same dose of atropine inhibited the maximal gastrin response to the muscarinic agonist, methacholine, by 80%. Atropine 17-25 gastrin Rattus norvegicus 48-55 7380199-0 1980 Effects of carbachol and atropine on gastrin secretion and synthesis in rat antral organ culture. Atropine 25-33 gastrin Rattus norvegicus 37-44 6129170-4 1982 Both inhibition of stimulated SLI and augmentation of gastrin release were completely abolished by atropine (10(-6) M). Atropine 99-107 gastrin Rattus norvegicus 54-61 7274550-4 1981 Atropine blocked the vagal release of IR-gastrin but not IR-VIP whereas hexamethonium blocked both responses. Atropine 0-8 gastrin Rattus norvegicus 41-48 6104441-4 1980 The maximal gastrin response (434 +/- 89% above basal levels; P less than 0.001) was partially inhibited by 10(-8) M atropine and completely inhibited by 10(-7) M atropine. Atropine 117-125 gastrin Rattus norvegicus 12-19 6104441-4 1980 The maximal gastrin response (434 +/- 89% above basal levels; P less than 0.001) was partially inhibited by 10(-8) M atropine and completely inhibited by 10(-7) M atropine. Atropine 163-171 gastrin Rattus norvegicus 12-19 7380199-7 1980 However, carbachol-stimulated gastrin release was inhibited progressively by inclusion of increasing concentrations of atropine in the culture media. Atropine 119-127 gastrin Rattus norvegicus 30-37 7380199-2 1980 In addition, the effect of atropine on basal and carbachol-stimulated gastrin release was investigated. Atropine 27-35 gastrin Rattus norvegicus 70-77 727256-6 1978 Cholinergic interruption by atropine or vagotomy elevated endogenous serum gastrin concentrations, indicating that the observed DNA stimulation may be mediated by hypergastrinemia. Atropine 28-36 gastrin Rattus norvegicus 75-82 5089711-0 1971 Inhibition of gastrin-induced gastric secretion by atropine in innervated and denervated pouches in the conscious rat. Atropine 51-59 gastrin Rattus norvegicus 14-21 4938464-5 1971 A plateau secretion of acid obtained by infusion of submaximal doses of hog gastrin II, was significantly inhibited by atropine in the Pavlov and the Heidenhain pouch.5. Atropine 119-127 gastrin Rattus norvegicus 76-83 5158190-0 1971 [Atropine inhibition of gastric secretion in rats stimulated with exogenous or endogenous gastrin]. Atropine 1-9 gastrin Rattus norvegicus 90-97 12508367-9 2003 Furthermore, combined infusion of the somatostatin-antagonist and atropine completely abolished distention-induced inhibition of gastrin release. Atropine 66-74 gastrin Rattus norvegicus 129-136