PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21908709-1 2011 Human fatty acid synthase (hFAS) is a homodimeric multidomain enzyme that catalyzes a series of reactions leading to the de novo biosynthesis of long-chain fatty acids, mainly palmitate. long-chain fatty acids 145-167 fatty acid synthase Homo sapiens 6-25 22485149-1 2012 Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors. long-chain fatty acids 77-99 fatty acid synthase Homo sapiens 0-19 22485149-1 2012 Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors. long-chain fatty acids 77-99 fatty acid synthase Homo sapiens 21-25 18635971-1 2008 Fatty Acid Synthase (FASN), a cytoplasmic biosynthetic enzyme, is the major source of long-chain fatty acids, particularly palmitate. long-chain fatty acids 86-108 fatty acid synthase Homo sapiens 0-19 18723500-1 2008 Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer. long-chain fatty acids 81-103 fatty acid synthase Homo sapiens 14-33 18723500-1 2008 Expression of fatty acid synthase (FASN), the key enzyme in de novo synthesis of long-chain fatty acids, is normally low but increases in cancer. long-chain fatty acids 81-103 fatty acid synthase Homo sapiens 35-39 20067991-1 2010 Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids, is involved in both normal lipid synthesis and cancer development. long-chain fatty acids 58-80 fatty acid synthase Homo sapiens 0-19 20067991-1 2010 Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids, is involved in both normal lipid synthesis and cancer development. long-chain fatty acids 58-80 fatty acid synthase Homo sapiens 21-25 19723916-2 2009 Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids and is overexpressed in most human solid tumors. long-chain fatty acids 53-75 fatty acid synthase Homo sapiens 0-19 19723916-2 2009 Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids and is overexpressed in most human solid tumors. long-chain fatty acids 53-75 fatty acid synthase Homo sapiens 21-24 19517019-3 2009 Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73. long-chain fatty acids 58-80 fatty acid synthase Homo sapiens 0-19 19517019-3 2009 Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73. long-chain fatty acids 58-80 fatty acid synthase Homo sapiens 21-25 18635971-1 2008 Fatty Acid Synthase (FASN), a cytoplasmic biosynthetic enzyme, is the major source of long-chain fatty acids, particularly palmitate. long-chain fatty acids 86-108 fatty acid synthase Homo sapiens 21-25 17168665-1 2006 The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the reductive de novo synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and nicotinamide adenine dinucleotide phosphate -NADPH-) is extremely low in nearly all nonmalignant adult tissues, whereas it is significantly up-regulated or activated in many cancer types, thus creating the potential for a large therapeutic index. long-chain fatty acids 120-142 fatty acid synthase Homo sapiens 31-50 17168665-1 2006 The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the reductive de novo synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and nicotinamide adenine dinucleotide phosphate -NADPH-) is extremely low in nearly all nonmalignant adult tissues, whereas it is significantly up-regulated or activated in many cancer types, thus creating the potential for a large therapeutic index. long-chain fatty acids 120-142 fatty acid synthase Homo sapiens 52-56 29541228-1 2018 Fatty acid synthase (FASN) is the key enzyme required for the de novo synthesis of long-chain fatty acids. long-chain fatty acids 83-105 fatty acid synthase Homo sapiens 0-19 16753600-1 2006 Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids. long-chain fatty acids 65-87 fatty acid synthase Homo sapiens 0-19 15878185-2 2005 Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (beta-oxidation) occurs in mitochondria and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step for the entry of fatty acids into the mitochondria. long-chain fatty acids 95-117 fatty acid synthase Homo sapiens 0-19 15878185-2 2005 Fatty acid synthase (FAS) catalyzes the condensation of acetyl-CoA and malonyl-CoA to generate long-chain fatty acids in the cytoplasm, while the breakdown of fatty acids (beta-oxidation) occurs in mitochondria and is regulated by carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting step for the entry of fatty acids into the mitochondria. long-chain fatty acids 95-117 fatty acid synthase Homo sapiens 21-24 10769045-1 2000 Animal fatty acid synthase (FAS) is a homodimer protein which synthesizes long-chain fatty acids and is rich in liver, brain, breast, and lung. long-chain fatty acids 74-96 fatty acid synthase Homo sapiens 7-26 17021367-2 2006 Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids, whereas the breakdown of fatty acids by beta-oxidation is regulated by carnitine palmitoyltransferase-1, the rate-limiting enzyme for the entry of fatty acids into the mitochondria for oxidation. long-chain fatty acids 53-75 fatty acid synthase Homo sapiens 0-19 17021367-2 2006 Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids, whereas the breakdown of fatty acids by beta-oxidation is regulated by carnitine palmitoyltransferase-1, the rate-limiting enzyme for the entry of fatty acids into the mitochondria for oxidation. long-chain fatty acids 53-75 fatty acid synthase Homo sapiens 21-24 16374067-1 2005 OBJECTIVE: A key enzyme of fatty acid synthesis, fatty acid synthase (FAS), is expressed in human cancers, including squamous-cell carcinoma of the lung, and long-chain fatty acids are intracellularly transported and/or taken up from blood by fatty-acid-binding proteins (FABPs). long-chain fatty acids 158-180 fatty acid synthase Homo sapiens 49-68 16374067-1 2005 OBJECTIVE: A key enzyme of fatty acid synthesis, fatty acid synthase (FAS), is expressed in human cancers, including squamous-cell carcinoma of the lung, and long-chain fatty acids are intracellularly transported and/or taken up from blood by fatty-acid-binding proteins (FABPs). long-chain fatty acids 158-180 fatty acid synthase Homo sapiens 70-73 32694731-3 2020 Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-function mutation in fatty acid synthase (FASN), whose product catalyses the formation of long-chain fatty acids. long-chain fatty acids 225-247 fatty acid synthase Homo sapiens 156-175 32694731-3 2020 Here, we use pooled genome-wide CRISPR screens to systematically map genetic interactions (GIs) in human HAP1 cells carrying a loss-of-function mutation in fatty acid synthase (FASN), whose product catalyses the formation of long-chain fatty acids. long-chain fatty acids 225-247 fatty acid synthase Homo sapiens 177-181 32434239-4 2021 Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses the synthesis of long-chain fatty acids, in VAT of the same subjects and whether it is associated with metabolic traits. long-chain fatty acids 100-122 fatty acid synthase Homo sapiens 40-44 32434239-4 2021 Moreover, we studied DNA methylation of FASN (fatty acid synthase), that catalyses the synthesis of long-chain fatty acids, in VAT of the same subjects and whether it is associated with metabolic traits. long-chain fatty acids 100-122 fatty acid synthase Homo sapiens 46-65 29463677-2 2018 For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of this enzyme in this response remains poorly defined. long-chain fatty acids 89-111 fatty acid synthase Homo sapiens 28-47 29463677-2 2018 For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response in macrophages; however, the precise role of this enzyme in this response remains poorly defined. long-chain fatty acids 89-111 fatty acid synthase Homo sapiens 49-53 29541228-1 2018 Fatty acid synthase (FASN) is the key enzyme required for the de novo synthesis of long-chain fatty acids. long-chain fatty acids 83-105 fatty acid synthase Homo sapiens 21-25 26680361-2 2016 FAS synthesizes long-chain fatty acids from three substrates: acetyl-CoA as a primer, malonyl-CoA as a 2 carbon donor, and NADPH for reduction. long-chain fatty acids 16-38 fatty acid synthase Homo sapiens 0-3