PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7845539-2	1994	Treatment of these cells with PACAP 27/38 led to a dose-dependent increase in cAMP content and ACTH accumulation in the medium with an apparent ED50 value close to 10(-9) M. The genomic effects of PACAP were first investigated by using a reporter gene containing a cAMP responsive element (CRE: TGACGTCA) PACAP 27/38 stimulate transcription from this construction and the effect is further increased when cells are cotreated with the phosphodiesterase inhibitor rolipram.	Rolipram	462-470	adenylate cyclase activating polypeptide 1	Mus musculus	30-35	
20388963-9	2009	Among the PDE inhibitors tested, only rolipram (PDE4 inhibitor) significantly increased basal acid secretion and potentiated the acid responses to histamine and PACAP.	Rolipram	38-46	adenylate cyclase activating polypeptide 1	Mus musculus	161-166	
20388963-11	2009	Furthermore, rolipram significantly increased cAMP production induced in the isolated stomach by histamine and PACAP.	Rolipram	13-21	adenylate cyclase activating polypeptide 1	Mus musculus	111-116