PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18474109-2	2008	PS1 is regarded as an atypical aspartyl protease harboring two essential aspartic acids in the context of the sequence D257LV and D385FI, respectively, rather than the typical DTG...DTG catalytic motif of classical aspartyl proteases.	dolutegravir	176-179	presenilin 1	Homo sapiens	0-3	
18474109-2	2008	PS1 is regarded as an atypical aspartyl protease harboring two essential aspartic acids in the context of the sequence D257LV and D385FI, respectively, rather than the typical DTG...DTG catalytic motif of classical aspartyl proteases.	dolutegravir	182-185	presenilin 1	Homo sapiens	0-3	
18474109-3	2008	In the present studies, we introduced the sequence DTG in PS1 at and around the catalytic D257 and D385 residues to generate three PS1 mutants: D257TG, D385TG, and the double-mutant D257TG/D385TG.	dolutegravir	51-54	presenilin 1	Homo sapiens	58-61	
18474109-3	2008	In the present studies, we introduced the sequence DTG in PS1 at and around the catalytic D257 and D385 residues to generate three PS1 mutants: D257TG, D385TG, and the double-mutant D257TG/D385TG.	dolutegravir	51-54	presenilin 1	Homo sapiens	131-134