PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23899439-2 2013 A Phase I open-label pharmacokinetic (PK) study was performed to describe first dose (PK1) and steady-state (PK2) PKs of the integrase inhibitor dolutegravir (DTG) in blood plasma (BP), cervicovaginal fluid (CVF), cervical tissue (CT) and vaginal tissue (VT) in HIV type-1-negative women. dolutegravir 145-157 prokineticin 2 Homo sapiens 109-112 23899439-11 2013 Accumulation of DTG from PK1 to PK2 occurred in BP, CT and VT, but only marginally in CVF. dolutegravir 16-19 prokineticin 2 Homo sapiens 32-35 23899439-14 2013 At PK2, DTG accumulated to a greater extent in tissue than in BP or CVF, suggesting increased tissue affinity. dolutegravir 8-11 prokineticin 2 Homo sapiens 3-6