PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30804050-7 2019 The kinetic data from expression systems suggested the major enzymes in each tissue: hepatic UGT1A9 > UGT1A1 (dolutegravir and raltegravir) and UGT1A1 (cabotegravir), intestinal UGT1A3 > UGT1A8 > UGT1A1 (dolutegravir) and UGT1A8 > UGT1A1 (raltegravir), and renal UGT1A9 (dolutegravir and raltegravir). dolutegravir 113-125 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 93-99 23132334-5 2013 UDP-glucuronosyltransferase (UGT) 1A1 is the main enzyme responsible for the metabolism of DTG in vivo, with cytochrome P450 (P450) 3A4 being a notable pathway and UGT1A3 and UGT1A9 being only minor pathways. dolutegravir 91-94 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 175-181