PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19000789-0 2009 Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists. pregna-4,17-diene-3,16-dione 0-13 toll like receptor 4 Homo sapiens 88-92 29543509-9 2018 These findings indicate that guggulsterone blocks the hyperactivation of macrophages via TREM-1 suppression and induces M2 polarization via IL-10 mediated by the TLR4 signaling pathway. pregna-4,17-diene-3,16-dione 29-42 toll like receptor 4 Homo sapiens 162-166