PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20971513-8	2010	Furthermore, LPS-induced IkB-alpha degradation was suppressed by the guggulsterone pretreatment.	pregna-4,17-diene-3,16-dione	69-82	NFKB inhibitor alpha	Homo sapiens	25-34	
18495175-7	2008	Although the NF-kappaB binding activity and nuclear p50 and p65 subunit levels, as well as IkappaBalpha degradation in the cytoplasm was greater in cells stimulated with IL-1beta than in unstimulated cells, treatment with guggulsterone abolished all of these increases.	pregna-4,17-diene-3,16-dione	222-235	NFKB inhibitor alpha	Homo sapiens	91-103	
16428513-6	2006	We found that treatment of monocytes with guggulsterone suppressed RANKL-activated NF-kappaB activation (as indicated by gel-shift assay) and that this suppression correlated with inhibition of IkappaBalpha kinase and phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	pregna-4,17-diene-3,16-dione	42-55	NFKB inhibitor alpha	Homo sapiens	194-206	
16428513-6	2006	We found that treatment of monocytes with guggulsterone suppressed RANKL-activated NF-kappaB activation (as indicated by gel-shift assay) and that this suppression correlated with inhibition of IkappaBalpha kinase and phosphorylation and degradation of IkappaBalpha, an inhibitor of NF-kappaB.	pregna-4,17-diene-3,16-dione	42-55	NFKB inhibitor alpha	Homo sapiens	253-265