PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12705905-0	2003	Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.	pregna-4,17-diene-3,16-dione	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	60-81	
15307955-9	2004	The pattern of BSEP and kininogen regulation by PUFAs is closely similar to that of the guggulsterone, previously reported as a selective bile acid receptor modulator.	pregna-4,17-diene-3,16-dione	88-101	ATP binding cassette subfamily B member 11	Homo sapiens	15-19	
12705905-3	2003	Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene.	pregna-4,17-diene-3,16-dione	114-127	ATP binding cassette subfamily B member 11	Homo sapiens	40-44	
12705905-3	2003	Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene.	pregna-4,17-diene-3,16-dione	114-127	ATP binding cassette subfamily B member 11	Homo sapiens	176-180	
12525500-0	2003	Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.	pregna-4,17-diene-3,16-dione	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	122-143	
12525500-12	2003	Taken together, these data suggest that guggulsterone defines a novel class of FXR ligands characterized by antagonist activities in coactivator association assays but with the ability to enhance the action of agonists on BSEP expression in vivo.	pregna-4,17-diene-3,16-dione	40-53	ATP binding cassette subfamily B member 11	Homo sapiens	222-226	
22246918-0	2012	Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump.	pregna-4,17-diene-3,16-dione	20-35	ATP binding cassette subfamily B member 11	Homo sapiens	98-119	
22246918-8	2012	Z-Guggulsterone underwent metabolism by CYP3A4, and the metabolites greatly increased the induction potency on BSEP but not on CES1.	pregna-4,17-diene-3,16-dione	0-15	ATP binding cassette subfamily B member 11	Homo sapiens	111-115	
17135343-0	2007	The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism.	pregna-4,17-diene-3,16-dione	24-37	ATP binding cassette subfamily B member 11	Homo sapiens	72-93	
17135343-4	2007	In this study, however, we have demonstrated that guggulsterone synergistically induced the expression of BSEP in cells treated with FXR agonist bile acids.	pregna-4,17-diene-3,16-dione	50-63	ATP binding cassette subfamily B member 11	Homo sapiens	106-110	
17135343-5	2007	A dissection study located in the BSEP promoter an activating protein (AP)-1 site supporting the action of guggulsterone.	pregna-4,17-diene-3,16-dione	107-120	ATP binding cassette subfamily B member 11	Homo sapiens	34-38	
17135343-7	2007	Selective c-Jun N-terminal kinase and extracellular signal-regulated kinase inhibitors markedly decreased the transactivation, suggesting an involvement of AP-1 activation pathway in the up-regulation of BSEP by guggulsterone.	pregna-4,17-diene-3,16-dione	212-225	ATP binding cassette subfamily B member 11	Homo sapiens	204-208	
17135343-8	2007	Consistent with its FXR antagonism, guggulsterone antagonized bile acid-mediated transactivation of BSEP promoter when the AP-1 element was disrupted.	pregna-4,17-diene-3,16-dione	36-49	ATP binding cassette subfamily B member 11	Homo sapiens	100-104	
17135343-9	2007	In conclusion, guggulsterone regulates BSEP expression through composite mechanisms, and the transactivation through the AP-1 element is dominant over the FXR-mediated antagonism.	pregna-4,17-diene-3,16-dione	15-28	ATP binding cassette subfamily B member 11	Homo sapiens	39-43	
17135343-10	2007	The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated hypolipidemic effect.	pregna-4,17-diene-3,16-dione	40-53	ATP binding cassette subfamily B member 11	Homo sapiens	21-25	
17135343-10	2007	The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated hypolipidemic effect.	pregna-4,17-diene-3,16-dione	169-182	ATP binding cassette subfamily B member 11	Homo sapiens	21-25