PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28339691-0	2017	Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.	pregna-4,17-diene-3,16-dione	0-15	brain derived neurotrophic factor	Mus musculus	87-91	
28339691-1	2017	Background: Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway.	pregna-4,17-diene-3,16-dione	12-27	brain derived neurotrophic factor	Mus musculus	175-208	
28339691-8	2017	Z-guggulsterone (10, 30 mg/kg) administration prevented the reductions in brain-derived neurotrophic factor protein expression levels as well as the phosphorylation levels of cAMP response element binding protein, extracellular signal-regulated kinase 1/2, and protein kinase B in the hippocampus and cortex induced by chronic unpredictable stress.	pregna-4,17-diene-3,16-dione	0-15	brain derived neurotrophic factor	Mus musculus	74-107	
28339691-10	2017	Blockade of the brain-derived neurotrophic factor signal, but not the monoaminergic system, attenuated the antidepressant-like effects of Z-guggulsterone.	pregna-4,17-diene-3,16-dione	138-153	brain derived neurotrophic factor	Mus musculus	16-49	
28339691-11	2017	Conclusions: Z-guggulsterone exhibits antidepressant activity via activation of the brain-derived neurotrophic factor signaling pathway and upregulation of hippocampal neurogenesis.	pregna-4,17-diene-3,16-dione	13-28	brain derived neurotrophic factor	Mus musculus	84-117	
27677871-0	2016	Z-Guggulsterone Improves the Scopolamine-Induced Memory Impairments Through Enhancement of the BDNF Signal in C57BL/6J Mice.	pregna-4,17-diene-3,16-dione	0-15	brain derived neurotrophic factor	Mus musculus	95-99	
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	pregna-4,17-diene-3,16-dione	34-49	brain derived neurotrophic factor	Mus musculus	170-203	
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	pregna-4,17-diene-3,16-dione	34-49	brain derived neurotrophic factor	Mus musculus	205-209	
27677871-8	2016	Inhibition of the BDNF signal, however, blocked the memory-enhancing effect of Z-guggulsterone.	pregna-4,17-diene-3,16-dione	79-94	brain derived neurotrophic factor	Mus musculus	18-22	
27677871-9	2016	Therefore, these findings demonstrate that Z-guggulsterone attenuates the scopolamine-induced memory impairments mainly through activation of the CREB-BDNF signaling pathway, thereby exhibiting memory-improving effects.	pregna-4,17-diene-3,16-dione	43-58	brain derived neurotrophic factor	Mus musculus	151-155