PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26622683-10	2015	In addition, guggulsterone-induced apoptosis of cholangiocarcinoma cells was demonstrated to be partially inhibited by the caspase inhibitors z-VAD-fmk, z-LEHD-fmk and z-IETD-fmk, accompanied by the activation of caspases-3, -8 and -9, accumulation of cleaved PARP and decreased expression of survivin and Bcl-2.	pregna-4,17-diene-3,16-dione	13-26	caspase 3	Homo sapiens	213-234	
33488300-8	2021	Bcl-2 protein expression was significantly decreased, and active caspase-3 and Bax protein expression was increased in SGC-7901 cells incubated with z-guggulsterone.	pregna-4,17-diene-3,16-dione	149-164	caspase 3	Homo sapiens	65-74	
31581454-6	2019	Our study evidenced that GS treatment altered expression of Bcl-2 mediated the mitochondrial release of cytochrome c which triggered the formation of apoptosome as well as activation of caspase-3/7 leading to death of HCT 116 cells via intrinsic apoptosis pathway.	pregna-4,17-diene-3,16-dione	25-27	caspase 3	Homo sapiens	186-195	
17475222-7	2007	The apoptosis induced by guggulsterone was also indicated by the activation of caspase-8, bid cleavage, cytochrome c release, caspase-9 activation, caspase-3 activation, and PARP cleavage.	pregna-4,17-diene-3,16-dione	25-38	caspase 3	Homo sapiens	148-157	
19232820-3	2009	Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8.	pregna-4,17-diene-3,16-dione	0-13	caspase 3	Homo sapiens	77-94	
17054793-4	2006	The effect of guggulsterone, an antagonist of bile acid receptors, on apoptosis of Barrett"s esophagus-derived cells was assessed morphologically, by flow cytometry and by measuring caspase 3 activity.	pregna-4,17-diene-3,16-dione	14-27	caspase 3	Homo sapiens	182-191	
17054793-9	2006	In vitro treatment with guggulsterone was associated with a significant increase in the percentage of apoptotic cells and of the caspase 3 activity.	pregna-4,17-diene-3,16-dione	24-37	caspase 3	Homo sapiens	129-138	
16275996-8	2005	Guggulsterone treatment resulted in cleavage (activation) of caspase-9, caspase-8, and caspase-3, and guggulsterone-induced cell death was significantly attenuated in the presence of general caspase inhibitor as well as specific inhibitors of caspase-9 and caspase-8.	pregna-4,17-diene-3,16-dione	0-13	caspase 3	Homo sapiens	87-96