PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33924157-9	2021	The mechanistic studied revealed that (E)-guggulsterone stimulates Nrf2-mediated heme oxygenase-1 (HO-1) expression, which increases the antiviral interferon responses and downstream antiviral gene expression by blocking DENV NS2B/3B protease activity.	pregna-4,17-diene-3,16-dione	38-55	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71	
22095074-0	2012	Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.	pregna-4,17-diene-3,16-dione	0-13	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76	
22095074-6	2012	cis-GS treatment enhanced nuclear translocation and ARE-binding activity of Nrf2.	pregna-4,17-diene-3,16-dione	0-6	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80	
22095074-7	2012	MCF10A cells transfected with an ARE luciferase construct exhibited significantly elevated Nrf2 transcriptional activity upon cis-GS treatment compared with cells transfected with the control vector.	pregna-4,17-diene-3,16-dione	126-132	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95	
22095074-10	2012	The pharmacological inhibition of phosphoinositide 3-kinase (PI3K), an upstream kinase responsible for Akt phosphorylation, abrogated cis-GS-induced Nrf2 nuclear translocation.	pregna-4,17-diene-3,16-dione	134-140	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153	
22095074-11	2012	Pretreatment with the thiol-reducing agents attenuated Akt phosphorylation, Nrf2 activation and HO-1 expression, suggesting that cis-GS may cause thiol modification of an upstream signaling modulator.	pregna-4,17-diene-3,16-dione	129-135	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80