PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25898852-4	2015	With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release.	cyclopamine	103-114	CD44 molecule (Indian blood group)	Homo sapiens	194-198	
21630164-9	2011	RESULTS: CD44, CD133 and the expression level of HH members, including Shh, SMO, Gli-1, were found to be highly expressed in gemcitabine-resistant cells, which were significantly down-regulated by cyclopamine treatment.	cyclopamine	197-208	CD44 molecule (Indian blood group)	Homo sapiens	9-13	
20971508-0	2011	Cyclopamine induces eosinophilic differentiation and upregulates CD44 expression in myeloid leukemia cells.	cyclopamine	0-11	CD44 molecule (Indian blood group)	Homo sapiens	65-69	
20971508-5	2011	Combined treatment with cyclopamine and a monoclonal antibody to ligate CD44 more than additively induced the differentiation of HL-60 cells.	cyclopamine	24-35	CD44 molecule (Indian blood group)	Homo sapiens	72-76	
18365871-3	2007	Importantly, the combination of mitoxantrone plus gefitinib and/or cyclopamine also caused a higher rate of apoptotic death of PC cells including enriched fraction of CD44(high) PC3 cell subpopulation as compared to the individual agents or bi-combination of drugs.	cyclopamine	67-78	CD44 molecule (Indian blood group)	Homo sapiens	167-171	
21838786-9	2011	Our results suggest that this semi-quantitative immunohistochemical analysis is valuable for detecting a small population of cells in cancer tissues and that the hedgehog signaling pathway inhibitor cyclopamine is useful for regulating the CD44(+) /CD24(-) tumor cells in breast cancer.	cyclopamine	199-210	CD44 molecule (Indian blood group)	Homo sapiens	240-244