PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26917208-0	2016	Activity of ABCG2 Is Regulated by Its Expression and Localization in DHT and Cyclopamine-Treated Breast Cancer Cells.	cyclopamine	77-88	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	12-17	
26917208-2	2016	In this study, gene expression analysis identified that treatment of the MCF-7 and T-47D breast cancer cell lines with the androgen, 5alpha-dihydrotestosterone (DHT), and the Hedgehog signaling inhibitor, cyclopamine downregulated ABCG2 mRNA levels.	cyclopamine	205-216	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	231-236	
26917208-5	2016	In contrast, cyclopamine, which did not alter ABCG2 protein levels, induced accumulation of ABCG2 in cytoplasmic vesicles, reducing its localization in cell-to-cell junction complexes.	cyclopamine	13-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-97	
26917208-6	2016	The reduced localization of ABCG2 at the plasma membrane of MCF-7 cells was associated with decreased efflux of the ABCG2 substrate, mitoxantrone, and increased sensitivity of cyclopamine-treated cultures to the cytotoxic effects of mitoxantrone.	cyclopamine	176-187	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33	
26917208-7	2016	Together, these findings indicate that DHT and cyclopamine reduce ABCG2 activity in breast cancer cells by distinct mechanisms, providing evidence to advocate the adjunct use of analogous pharmaceutics to increase or prolong the efficacy of breast cancer treatments.	cyclopamine	47-58	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	66-71	
22923052-7	2012	Cyclopamine reversed chemoresistance to gemcitabine,             resulting in decreased expression of ABCG2 in PANC-1 tumorspheres.	cyclopamine	0-11	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	102-107	
22428030-6	2012	Finally, we show that the H460 SP cells preferentially express ABCG2 as well as SMO, a critical mediator of the Hedgehog (HH) signaling, which seems to play an important role in H460 lung cancer cells as its blockage using Cyclopamine greatly inhibits cell-cycle progression.	cyclopamine	223-234	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-68	
21774076-4	2011	In addition, cyclopamine is able to modulate, along with oxysterols and other products, the ABCG2 transporter by increasing Ho342 and mitoxantrone uptake.	cyclopamine	13-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	92-97	
21625222-11	2011	Finally, functional inhibition of ABCG2 drug efflux activity with fumitremorgin C or inhibition of Hh signaling with cyclopamine-KAAD abrogated the stroma-induced chemotolerance suggesting that targeting ABCG2 and Hh signaling may have therapeutic value in overcoming chemoresistance in DLBCL.	cyclopamine	117-128	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	204-209