PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30247801-4	2018	Mechanism analysis found that tigecycline led to cell cycle arrest at G0/G1 with down-regulation of p21, CDK2 and cyclin D1, rather than induced apoptosis, in MM cells.	Tigecycline	30-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-103	
26621850-0	2016	Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner.	Tigecycline	16-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-85	
26621850-0	2016	Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner.	Tigecycline	16-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-90	
26621850-9	2016	We found that p21 overexpression significantly rescued tigecycline-induced cell proliferation inhibition as well as migration and invasion suppression.	Tigecycline	55-66	cyclin dependent kinase inhibitor 1A	Homo sapiens	14-17	
26621850-10	2016	Taken together, our results revealed that the essential role of p21 in the inhibitory effect of tigecycline on proliferation, migration and invasion of melanoma.	Tigecycline	96-107	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-67