PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26621850-0 2016 Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner. Tigecycline 16-27 cyclin dependent kinase inhibitor 1A Homo sapiens 78-85 30247801-4 2018 Mechanism analysis found that tigecycline led to cell cycle arrest at G0/G1 with down-regulation of p21, CDK2 and cyclin D1, rather than induced apoptosis, in MM cells. Tigecycline 30-41 cyclin dependent kinase inhibitor 1A Homo sapiens 100-103 26621850-0 2016 Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner. Tigecycline 16-27 cyclin dependent kinase inhibitor 1A Homo sapiens 86-90 26621850-9 2016 We found that p21 overexpression significantly rescued tigecycline-induced cell proliferation inhibition as well as migration and invasion suppression. Tigecycline 55-66 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 26621850-10 2016 Taken together, our results revealed that the essential role of p21 in the inhibitory effect of tigecycline on proliferation, migration and invasion of melanoma. Tigecycline 96-107 cyclin dependent kinase inhibitor 1A Homo sapiens 64-67