PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20160032-0 2010 Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate. ethyl pyruvate 83-97 indoleamine 2,3-dioxygenase 1 Homo sapiens 33-60 20160032-2 2010 In this report, we offer preclinical evidence that the low-cost, anti-inflammatory agent ethyl pyruvate elicits a potent immune-based antitumor response through inhibition of indoleamine 2,3-dioxygenase (IDO), a key tolerogenic enzyme for many human tumors. ethyl pyruvate 89-103 indoleamine 2,3-dioxygenase 1 Homo sapiens 175-202 20160032-2 2010 In this report, we offer preclinical evidence that the low-cost, anti-inflammatory agent ethyl pyruvate elicits a potent immune-based antitumor response through inhibition of indoleamine 2,3-dioxygenase (IDO), a key tolerogenic enzyme for many human tumors. ethyl pyruvate 89-103 indoleamine 2,3-dioxygenase 1 Homo sapiens 204-207 20160032-3 2010 Consistent with its reported ability to interfere with NF-kappaB function, ethyl pyruvate blocks IDO induction both in vitro and in vivo. ethyl pyruvate 75-89 indoleamine 2,3-dioxygenase 1 Homo sapiens 97-100 20160032-8 2010 Our findings that IDO is effectively blocked by ethyl pyruvate treatment deepen emerging links between IDO and inflammatory processes. ethyl pyruvate 48-62 indoleamine 2,3-dioxygenase 1 Homo sapiens 18-21 20160032-8 2010 Our findings that IDO is effectively blocked by ethyl pyruvate treatment deepen emerging links between IDO and inflammatory processes. ethyl pyruvate 48-62 indoleamine 2,3-dioxygenase 1 Homo sapiens 103-106 32560527-7 2020 We also analyzed the combinatorial antitumor effect of vaccination with RL2-treated cells and the inhibition of indoleamine 2,3-dioxygenase (IDO) with ethyl pyruvate. ethyl pyruvate 151-165 indoleamine 2,3-dioxygenase 1 Homo sapiens 112-139 32560527-7 2020 We also analyzed the combinatorial antitumor effect of vaccination with RL2-treated cells and the inhibition of indoleamine 2,3-dioxygenase (IDO) with ethyl pyruvate. ethyl pyruvate 151-165 indoleamine 2,3-dioxygenase 1 Homo sapiens 141-144