PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24453420-8 2013 The expression of Bcl-2, Bax, Beclin-1, and LC3, which play an important role in the regulation of intrinsic pathway of apoptosis and autophagy, was also obviously decreased by ethyl pyruvate (80 mg/kg). ethyl pyruvate 177-191 beclin 1, autophagy related Mus musculus 30-38 24453420-10 2013 CONCLUSION: Our results showed that ethyl pyruvate might attenuate to hepatic I/R injury by inhibiting intrinsic pathway of apoptosis and autophagy, mediated partly through downregulation of HMGB1/TLR4/ NF-kappab axis and the competitive interaction with Beclin-1 of HMGB1. ethyl pyruvate 36-50 beclin 1, autophagy related Mus musculus 255-263