PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31072024-0	2019	Ethyl Pyruvate Directly Attenuates Active Secretion of HMGB1 in Proximal Tubular Cells via Induction of Heme Oxygenase-1.	ethyl pyruvate	0-14	heme oxygenase 1	Mus musculus	104-120	
22715434-9	2012	In contrast, administration of ethyl pyruvate before high stretch mechanical ventilation prevented lung edema formation, inflammatory cytokine production, neutrophil accumulation, oxidative stress and HMGB1 and HO-1 expression.	ethyl pyruvate	31-45	heme oxygenase 1	Mus musculus	211-215	
19454652-8	2009	Furthermore, ethyl pyruvate induced HO-1 expression in intestinal tissue.	ethyl pyruvate	13-27	heme oxygenase 1	Mus musculus	36-40	
22369644-0	2012	Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.	ethyl pyruvate	0-14	heme oxygenase 1	Mus musculus	23-39	
22369644-1	2012	AIMS: We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(-/-)) septic mice.	ethyl pyruvate	55-69	heme oxygenase 1	Mus musculus	83-99	
22369644-1	2012	AIMS: We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(-/-)) septic mice.	ethyl pyruvate	55-69	heme oxygenase 1	Mus musculus	101-105	
22369644-1	2012	AIMS: We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(-/-)) septic mice.	ethyl pyruvate	55-69	heme oxygenase 1	Mus musculus	222-226	
22369644-1	2012	AIMS: We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(-/-)) septic mice.	ethyl pyruvate	55-69	heme oxygenase 1	Mus musculus	222-226	
19454652-12	2009	Additionally, ethyl pyruvate induced HO-1 mRNA and protein expression and HO-1 promoter activation.	ethyl pyruvate	14-28	heme oxygenase 1	Mus musculus	37-41	
19454652-12	2009	Additionally, ethyl pyruvate induced HO-1 mRNA and protein expression and HO-1 promoter activation.	ethyl pyruvate	14-28	heme oxygenase 1	Mus musculus	74-78