PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11111075-3 2000 Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate. farnesyl pyrophosphate 201-220 mevalonate kinase Homo sapiens 22-39 18302342-1 2008 Mevalonate kinase (MK), which catalyzes a key reaction in polyisoprenoid and sterol metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related compounds. farnesyl pyrophosphate 151-171 mevalonate kinase Homo sapiens 0-17 18302342-1 2008 Mevalonate kinase (MK), which catalyzes a key reaction in polyisoprenoid and sterol metabolism in many organisms, is subject to feedback regulation by farnesyl diphosphate and related compounds. farnesyl pyrophosphate 151-171 mevalonate kinase Homo sapiens 19-21 32256770-0 2020 Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate. farnesyl pyrophosphate 155-177 mevalonate kinase Homo sapiens 11-28 32256770-10 2020 The mRNA and protein expression levels of keratin 1 and involucrin were significantly decreased following interference of MVK expression, and the decrease was markedly attenuated by FPP. farnesyl pyrophosphate 182-185 mevalonate kinase Homo sapiens 122-125 32256770-15 2020 FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42. farnesyl pyrophosphate 0-3 mevalonate kinase Homo sapiens 21-24