PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20836852-11 2010 Knockdown of N-SMase 2 by siRNA and inhibitor of N-SMase (GW4869) significantly reduced WithaD-induced ceramide generation and phosphorylation of MKK4 and MKK3/6, whereas phosphorylation of MKK7 was moderately regulated in leukemic cells. GW 4869 58-64 mitogen-activated protein kinase kinase 3 Homo sapiens 155-161