PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20877132-6 2010 For other cyclooxygenase-2 inhibitors celecoxib, etoricoxib, rofecoxib and valdecoxib, slight to moderate inhibition of hOAT3 only was observed. Etoricoxib 49-59 solute carrier family 22 member 8 Homo sapiens 120-125 21457143-0 2011 Inhibitory effect of selective cyclooxygenase-2 inhibitor etoricoxib on human organic anion transporter 3 (hOAT3). Etoricoxib 58-68 solute carrier family 22 member 8 Homo sapiens 78-105 21457143-0 2011 Inhibitory effect of selective cyclooxygenase-2 inhibitor etoricoxib on human organic anion transporter 3 (hOAT3). Etoricoxib 58-68 solute carrier family 22 member 8 Homo sapiens 107-112 21457143-3 2011 In this study, we evaluated the inhibitory effects of selective cyclooxygenase-2 inhibitor etoricoxib on hOAT3 by uptake experiments using Xenopus laevis oocytes. Etoricoxib 91-101 solute carrier family 22 member 8 Homo sapiens 105-110 21457143-4 2011 The injection of hOAT3 cRNA stimulated the uptake of methotrexate into the oocytes, and its transport was inhibited by etoricoxib. Etoricoxib 119-129 solute carrier family 22 member 8 Homo sapiens 17-22 21457143-5 2011 Etoricoxib inhibited estrone sulfate uptake by hOAT3 dose dependently, and the 50% inhibitory concentration was estimated to be 9.8 microM. Etoricoxib 0-10 solute carrier family 22 member 8 Homo sapiens 47-52 21457143-6 2011 Eadie-Hofstee plot analysis showed that etoricoxib inhibited hOAT3 in a competitive manner. Etoricoxib 40-50 solute carrier family 22 member 8 Homo sapiens 61-66 21457143-7 2011 These findings show that etoricoxib has inhibitory effect on hOAT3, and that the potential is comparable to that of traditional NSAIDs. Etoricoxib 25-35 solute carrier family 22 member 8 Homo sapiens 61-66