PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34029649-0	2021	Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice.	tetrahydropalmatine	0-24	cAMP responsive element binding protein 1	Mus musculus	128-132	
34029649-7	2021	Furthermore, L-THP (10.0 mg/kg) co-administered with fentanyl during conditioning prevented the enhanced phosphorylation of ERK and CREB in the Hip, NAc, and PFC.	tetrahydropalmatine	13-18	cAMP responsive element binding protein 1	Mus musculus	132-136	
34029649-8	2021	Our research revealed that L-THP could suppress the rewarding properties of fentanyl-induced CPP, the inhibitory effect may be related to the suppression of ERK and CREB phosphorylation in the Hip, NAc, and PFC of mice.	tetrahydropalmatine	27-32	cAMP responsive element binding protein 1	Mus musculus	165-169	
34029649-4	2021	Western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB) in related brain regions, including the hippocampus (Hip), caudate putamen (CPu), prefrontal cortex (PFC), and nucleus accumbens (NAc), which may mediate the effects of L-THP on fentanyl-induced CPP.	tetrahydropalmatine	354-359	cAMP responsive element binding protein 1	Mus musculus	179-183