PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34361644-0 2021 Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-beta1 Signaling Pathway. Fedratinib 0-10 signal transducer and activator of transcription 3 Homo sapiens 72-77 26252788-8 2015 Fedratinib treatment led to reduced STAT3 phosphorylation but no meaningful change in JAK2V617F allele burden. Fedratinib 0-10 signal transducer and activator of transcription 3 Homo sapiens 36-41 24165976-7 2014 The relationship between fedratinib exposure and suppression of STAT3 phosphorylation was described using an inhibitory effect sigmoid Emax model, with an EC50 of 1,210 ng/mL in healthy subjects. Fedratinib 25-35 signal transducer and activator of transcription 3 Homo sapiens 64-69 33356802-11 2021 Fedratinib, a JAK/STAT inhibitor was evaluated and 78% tumor efficacy response was achieved. Fedratinib 0-10 signal transducer and activator of transcription 3 Homo sapiens 18-22 25572535-4 2015 Using the pharmaceutical inhibitor TG101348 or knockdown of STAT3 reduced the number of Th17 cells while promoting the number and function of Treg cells via the Janus kinase2 (JAK2)/STAT3 pathway in ACS patients. Fedratinib 35-43 signal transducer and activator of transcription 3 Homo sapiens 182-187