PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32950500-0 2020 Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway. Naphthalimides 34-47 epidermal growth factor receptor Homo sapiens 144-148 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 epidermal growth factor receptor Homo sapiens 112-116 32950500-3 2020 We show here that gain-of-function p53 mutation in gastric cancer cells promotes tumorigenesis by enhancing p53-EGFR (epidermal growth factor receptor) signaling pathway, and such process can be blocked by small molecule NA20, a naphthalimide derivative that exhibited selective inhibition in p53 mutant gastric cancer cell lines. Naphthalimides 229-242 epidermal growth factor receptor Homo sapiens 118-150