PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28737377-0	2017	Carbon Dot Based, Naphthalimide Coupled FRET Pair for Highly Selective Ratiometric Detection of Thioredoxin Reductase and Cancer Screening.	Naphthalimides	18-31	peroxiredoxin 5	Homo sapiens	96-117	
28737377-1	2017	The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells.	Naphthalimides	111-124	peroxiredoxin 5	Homo sapiens	152-173	
28737377-1	2017	The fluorescence resonance energy transfer (FRET) mechanism has been established between carbon dots (CDs) and naphthalimide to monitor the activity of thioredoxin reductase (TrxR), which is often overexpressed in many cancer cells.	Naphthalimides	111-124	peroxiredoxin 5	Homo sapiens	175-179	
28737377-4	2017	However, contrary to this, the elevated levels of TrxR cause the breakage of disulfide bonds and consequently abolishes the FRET pair through the release of the naphthalimide moiety from the surface of CDs.	Naphthalimides	161-174	peroxiredoxin 5	Homo sapiens	50-54	
24803348-0	2014	Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators.	Naphthalimides	46-59	peroxiredoxin 5	Homo sapiens	80-101	
24803348-2	2014	The complexes were potent DNA intercalators related to their naphthalimide partial structure, inhibited TrxR as a consequence of the incorporation of the gold(I) moiety, and triggered efficient cytotoxic effects in MCF-7 breast and HT-29 colon adenocarcinoma cells.	Naphthalimides	61-74	peroxiredoxin 5	Homo sapiens	104-108	
24351040-3	2014	TRFS-green displays a green fluorescence off-on change induced by the TrxR-mediated disulfide cleavage and subsequent intramolecular cyclization to liberate the masked naphthalimide fluorophore.	Naphthalimides	168-181	peroxiredoxin 5	Homo sapiens	70-74	
24351040-5	2014	HPLC analyses indicated that TRFS-green was exclusively converted to naphthalimide catalyzed by TrxR.	Naphthalimides	69-82	peroxiredoxin 5	Homo sapiens	96-100