PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31121158-9	2019	Pretreatment with DOACs clearly limited the impact of thrombin on PAR-1 cleavage in our model, contrary to other anticoagulants, associated with ZO-1 and VE-cadherin expressions.	doacs	18-23	coagulation factor II thrombin receptor	Homo sapiens	66-71	
31121158-5	2019	Our hypothesis is that DOACs may limit the effects of thrombin on endothelial cells (of the BBB) alteration by a mechanism probably involving PAR-1 activation.	doacs	23-28	coagulation factor II thrombin receptor	Homo sapiens	142-147	
31121158-10	2019	In conclusion, DOACs seem to limit the alteration of the monolayer of endothelial cells of the BBB mediated by the thrombin/PAR-1 pathway.	doacs	15-20	coagulation factor II thrombin receptor	Homo sapiens	124-129