PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35001806-10	2022	Moreover, silencing of Sirtuin1 (SIRT1) abolished the effects of safinamide on the mRNA levels of p21 and PAI-1, as well as SA-beta-gal-positive cells in Abeta1-42 oligomers-induced M17 cells.	safinamide	65-75	sirtuin 1	Homo sapiens	23-31	
35001806-10	2022	Moreover, silencing of Sirtuin1 (SIRT1) abolished the effects of safinamide on the mRNA levels of p21 and PAI-1, as well as SA-beta-gal-positive cells in Abeta1-42 oligomers-induced M17 cells.	safinamide	65-75	sirtuin 1	Homo sapiens	33-38	
35001806-11	2022	In conclusion, we reveal that safinamide exerted a protective function on M17 cells from Abeta1-42 oligomers induction-caused oxidative stress and cellular senescence through SIRT1 signaling.	safinamide	30-40	sirtuin 1	Homo sapiens	175-180