PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34420370-1	2021	This study was conducted to test the hypothesis that the CYP1B1 (cytochrome P450 1B1)-testosterone metabolite 6beta-hydroxytestosterone contributes to angiotensin II-induced hypertension by promoting activation of group IV cPLA2alpha (cytosolic phospholipase A2alpha) and generation of prohypertensive eicosanoids in male mice.	6 beta-hydroxytestosterone	110-135	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	223-233	
34420370-6	2021	Antagonists of prostaglandin E2-EP1/EP3 receptors and thromboxane A2-TP receptors decreased the effect of 6beta-hydroxytestosterone in restoring the angiotensin II-induced increase in systolic blood pressure, cardiac and renal collagen deposition, and reactive oxygen species production in cPLA2alpha+/+/Cyp1b1-/- mice.	6 beta-hydroxytestosterone	106-131	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	290-300	
34420370-7	2021	These data suggest that 6beta-hydroxytestosterone promotes angiotensin II-induced increase in systolic blood pressure and associated pathogenesis via cPLA2alpha activation and generation of eicosanoids, most likely prostaglandin E2 and thromboxane A2 that exerts prohypertensive effects by stimulating EP1/EP3 and TP receptors, respectively.	6 beta-hydroxytestosterone	24-49	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	150-160