PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34653752-5 2021 We observed that 4HT and TAM induce estrogen antagonist effects when used at nanomolar concentrations, while pharmacological concentrations that are reached by TAM in clinical settings regulate the expression of VEGFalpha and other immune activation genes by ERalpha- and G protein-coupled receptor 1 (GPER1)-independent mechanisms that involve NRF2 through PI3K/Akt-dependent mechanisms. afimoxifene 17-20 G protein-coupled receptor 1 Mus musculus 272-300 34653752-5 2021 We observed that 4HT and TAM induce estrogen antagonist effects when used at nanomolar concentrations, while pharmacological concentrations that are reached by TAM in clinical settings regulate the expression of VEGFalpha and other immune activation genes by ERalpha- and G protein-coupled receptor 1 (GPER1)-independent mechanisms that involve NRF2 through PI3K/Akt-dependent mechanisms. afimoxifene 17-20 G protein-coupled receptor 1 Mus musculus 302-307