PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23418355-7 2013 We further demonstrate that tamoxifen and its metabolite 4-hydroxytamoxifen lead to prion degradation in an autophagy-independent manner by diverting the trafficking of both PrP and cholesterol to lysosomes. afimoxifene 57-75 prion protein Mus musculus 174-177