PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10893219-4	2000	Maximal IL-8 release was achieved with 10 ng/ml of TGF-beta1 after 16 h of incubation, which was inhibited by the transcription inhibitor actinomycin D and the corticosteroid dexamethasone but was not affected by the nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 despite their inhibition on TGF-beta1-induced PGE(2) release.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	291-297	C-X-C motif chemokine ligand 8	Homo sapiens	8-12	
12169581-3	2002	Bradykinin increased IL-8 generation in both a non-cystic fibrosis (A549) and cystic fibrosis epithelial cell line (CFTE29) that was inhibited by the nonselective cyclooxygenase (COX) inhibitor indomethacin and the COX-2 selective inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	241-247	C-X-C motif chemokine ligand 8	Homo sapiens	21-25	
9725250-9	1998	The nonselective COX inhibitor indomethacin and the selective COX-2 inhibitor NS-398 strongly inhibited BK-stimulated PGE2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	C-X-C motif chemokine ligand 8	Homo sapiens	127-131	
23843863-11	2013	Similar to the protective effects of S-[6]-gingerol, both NS-398 (a selective COX2 inhibitor) and PDTC (a selective NF kappa B inhibitor) suppressed mRNA levels of IL6, IL8, and SAA1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	169-172	
27312705-0	2016	Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1beta-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	58-64	C-X-C motif chemokine ligand 8	Homo sapiens	106-110	
23488692-9	2013	Furthermore, NS-398 reduced the production of IL-6 and IL-8, thus indicating that IL-1beta/HMGB1 complexes modulate cytokine production in part through prostanoid synthesis.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-19	C-X-C motif chemokine ligand 8	Homo sapiens	55-59	
27312705-5	2016	First, NS-398, instead of reducing inflammation, appeared to further enhance IL-1beta-mediated COX-2 and IL-8 production.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	7-13	C-X-C motif chemokine ligand 8	Homo sapiens	105-109	
27312705-8	2016	Flow cytometry analysis demonstrated that NS-398, in combination with IL-1beta, significantly enhanced cell cycle progression involving IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	136-140	
19376214-5	2009	The level of prostaglandin E(2), a major product of COX enzymes, increased in response to NaF exposure, and its production was abolished by the selective COX-2 inhibitor NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	170-176	C-X-C motif chemokine ligand 8	Homo sapiens	90-93	
21533553-6	2011	Inhibition of COX-2 by NS-398, a selective inhibitor of COX-2, significantly repressed the cytotoxicity, as well as secretion of IL-6 and IL-8 induced by CoCl(2).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	23-29	C-X-C motif chemokine ligand 8	Homo sapiens	138-142	
21779360-6	2011	Similar to the protective effect of H(2)S, both NS-398 (a selective COX-2 inhibitor) and PDTC (a selective NF-kappaB inhibitor) depressed not only CoCl(2)-induced cytotoxicity, but also the secretions of IL-1beta, IL-6 and IL-8.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	48-54	C-X-C motif chemokine ligand 8	Homo sapiens	223-227	
17709599-6	2008	Inhibition of cyclooxygenase (Cox)-2 with NS-398 was associated with reductions in Cox-2 (2-fold) and IL-6 (1.3-fold) mRNA transcripts, and in IL-8 and PGE-2 chemokine secretion.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-48	C-X-C motif chemokine ligand 8	Homo sapiens	143-147	
18096868-7	2008	The COX-2 inhibitor, NS-398, attenuated NiSO(4) and MALP-2-induced PGE2 and CXCL8 release and partially reversed the NiSO(4)-dependent inhibition of MALP-2-induced CXCL10 release from HLF.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	21-27	C-X-C motif chemokine ligand 8	Homo sapiens	76-81	
15997464-9	2005	Treatment with NS-398 severely diminished the IgE-dependently induced production of IL-8 and TNF-alpha.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-21	C-X-C motif chemokine ligand 8	Homo sapiens	84-88	
16678856-13	2006	Treatment with the COX-2 inhibitor NS-398 at a low 1-mu[scap]M dose reduced the production of IL-8 in COX-2-transfected MDA-231 cells by 30%, thus confirming the involvement of COX-2 in IL-8 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
16678856-13	2006	Treatment with the COX-2 inhibitor NS-398 at a low 1-mu[scap]M dose reduced the production of IL-8 in COX-2-transfected MDA-231 cells by 30%, thus confirming the involvement of COX-2 in IL-8 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-41	C-X-C motif chemokine ligand 8	Homo sapiens	186-190	
16428068-12	2006	Moreover, NS-398 suppressed the anti-apoptotic activity of IL-8 and IL-1beta, but did not induce COX-2; therefore, the pro-apoptotic mechanism of the selective COX-2 inhibitor may be unrelated to COX-2 activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-16	C-X-C motif chemokine ligand 8	Homo sapiens	59-63