PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30930248-7	2019	PTGS-2 inhibitors CAY10404 and NS398 effectively decreased the secretion of PGE2 and the expression of prostaglandin synthetases, pro-inflammatory factors and DAMPs, and alleviated LPS-induced tissue damage.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-36	prostaglandin-endoperoxide synthase 2	Bos taurus	0-6	
9374663-5	1997	NS-398 (500 nM), a specific PGHS-2 inhibitor, was ineffective.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	prostaglandin-endoperoxide synthase 2	Bos taurus	28-34	
24447957-8	2014	Treatment with PTGS2 selective inhibitor (NS398), PTGS2-specific siRNA or PTGER2-receptor antagonist (AH6809) resulted in ~20-25% reduction in nuclear maturation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	42-47	prostaglandin-endoperoxide synthase 2	Bos taurus	15-20	
24377862-8	2014	During IVM, PTGS2 activity inhibitor NS398 (50 muM) led to lower expression of fatty acid synthase (FASN) in CC and of MOS in treated metaphase-II oocytes.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	37-42	prostaglandin-endoperoxide synthase 2	Bos taurus	12-17	
21293029-3	2011	The specific inhibition of PTGS2 activity with NS-398 during in vitro maturation (IVM) significantly restricted mitogen-activated protein kinase (MAPK) activation in oocytes at the germinal vesicle breakdown stage and reduced both cumulus expansion and the maturation rate after 22 h of culture.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	47-53	prostaglandin-endoperoxide synthase 2	Bos taurus	27-32	
15216991-1	2004	Ultrasound-mediated intrafollicular injection and aspiration procedures were used to investigate the ability of the selective cyclooxygenase-2 inhibitor, NS-398, to inhibit intrafollicular PGE2 synthesis and suppress ovulation in dairy cattle.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	154-160	prostaglandin-endoperoxide synthase 2	Bos taurus	126-142	
15216991-0	2004	Inhibition of intrafollicular PGE2 synthesis and ovulation following ultrasound-mediated intrafollicular injection of the selective cyclooxygenase-2 inhibitor NS-398 in cattle.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	159-165	prostaglandin-endoperoxide synthase 2	Bos taurus	132-148	
18463360-10	2008	A specific inhibitor of cyclooxygenase (PTGS), PTGS2 (NS-398), also reduced cell viability, whereas an inhibitor of PTGS1 (FR122047) did not affect it.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-60	prostaglandin-endoperoxide synthase 2	Bos taurus	47-52	
16855213-6	2006	The prostaglandin-endoperoxide synthase 2 (PTGS2) inhibitor NS-398 caused a region-dependent decrease in SCs and tone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	60-66	prostaglandin-endoperoxide synthase 2	Bos taurus	4-41	
16855213-6	2006	The prostaglandin-endoperoxide synthase 2 (PTGS2) inhibitor NS-398 caused a region-dependent decrease in SCs and tone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	60-66	prostaglandin-endoperoxide synthase 2	Bos taurus	43-48	
12672504-10	2003	Furthermore, PgE-2 release following exposure of BBMEC monolayers to either LPS or the various amphotericin-B formulations was reduced by the addition of the selective COX-2 inhibitor, NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	185-191	prostaglandin-endoperoxide synthase 2	Bos taurus	168-173	
12419090-5	2002	In bovine iridial melanocytes, latanoprost acid caused a significant increase of the PGE(2) production, which could be blocked by indomethacin and NS398, indicating an involvement of cyclo-oxygenase 2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	147-152	prostaglandin-endoperoxide synthase 2	Bos taurus	183-200