PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17511040-7 2007 However, all of these changes were reversed by HIF-1alpha inhibitor NS398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 68-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 47-57 28365254-5 2017 Moreover, arecoline-induced HIF-1alpha expression was downregulated by mitogen-activated protein kinase inhibitor U0126, phosphatidylinositol 3-kinase inhibitor LY294002, p38 inhibitor SB203580, cyclooxygenase-2 inhibitor NS-398, and glutathione precursor N-acetyl-L-cysteine (p<0.05). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 222-228 hypoxia inducible factor 1 subunit alpha Homo sapiens 28-38 24692712-0 2014 COX2 inhibitor NS398 reduces HT-29 cell invasiveness by modulating signaling pathways mediated by EGFR and HIF1-alpha. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 15-20 hypoxia inducible factor 1 subunit alpha Homo sapiens 107-117 24692712-6 2014 Under normoxia, NS398 reduced signalling pathways induced by EGF [phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), extracellular-signal-regulated kinases (ERKs)], while under hypoxia, EGF stimulation and NS398 treatment was associated with HIF-1alpha expression. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 16-21 hypoxia inducible factor 1 subunit alpha Homo sapiens 250-260 12401798-10 2002 Two selective COX-2 inhibitors, meloxicam and NS398, decreased HIF-1alpha levels and nuclear localization, under both normoxic and hypoxic conditions. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 46-51 hypoxia inducible factor 1 subunit alpha Homo sapiens 63-73 15864753-10 2005 In addition, pretreatment with NS-398 to reduce PGE2 also effectively suppressed HIF-1alpha protein accumulation and achieved a similar inhibitory effect on VEGF production as did antisense HIF-1alpha transfection. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 81-91 15382039-0 2004 NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-5 hypoxia inducible factor 1 subunit alpha Homo sapiens 14-51 15382039-0 2004 NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-5 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-61 15382039-6 2004 NS398 also inhibits hypoxia-induced angiogenesis, which may be mediated by the inhibition of HIF-1 function in a COX-2-dependent manner. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-5 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-98 15382039-8 2004 On the one hand, NS398 decreases the expression of HIF-1alpha mRNA and reduces HIF-1alpha synthesis in a COX-2/PGE2 dependent way, which can be restored by addition of exogenous PGE2 that activates the phosphatidylinositol 3-kinase/AKT/p70s6k signaling pathway. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 17-22 hypoxia inducible factor 1 subunit alpha Homo sapiens 51-61 15382039-11 2004 These data not only confirm the inhibitory effect of NS398 on HIF-1alpha and HIF-1 transcriptional activity but also demonstrate that such an effect occurs at multiple levels involving both COX-2 dependent and independent mechanisms. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 53-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-72 15382039-11 2004 These data not only confirm the inhibitory effect of NS398 on HIF-1alpha and HIF-1 transcriptional activity but also demonstrate that such an effect occurs at multiple levels involving both COX-2 dependent and independent mechanisms. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 53-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 62-67 16527254-9 2006 In addition, pretreatment with NS-398 to inhibit COX-2 activity also effectively suppressed DFX-induced HIF-1alpha accumulation in human colon cancer cells, providing the evidence that COX-2 plays as a regulator of HIF-1alpha accumulation in DFX-treated colon cancer cells. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 104-114 16527254-9 2006 In addition, pretreatment with NS-398 to inhibit COX-2 activity also effectively suppressed DFX-induced HIF-1alpha accumulation in human colon cancer cells, providing the evidence that COX-2 plays as a regulator of HIF-1alpha accumulation in DFX-treated colon cancer cells. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 31-37 hypoxia inducible factor 1 subunit alpha Homo sapiens 215-225