PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28365254-5	2017	Moreover, arecoline-induced HIF-1alpha expression was downregulated by mitogen-activated protein kinase inhibitor U0126, phosphatidylinositol 3-kinase inhibitor LY294002, p38 inhibitor SB203580, cyclooxygenase-2 inhibitor NS-398, and glutathione precursor N-acetyl-L-cysteine (p<0.05).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	222-228	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38	
12401798-10	2002	Two selective COX-2 inhibitors, meloxicam and NS398, decreased HIF-1alpha levels and nuclear localization, under both normoxic and hypoxic conditions.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	46-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73	
24692712-0	2014	COX2 inhibitor NS398 reduces HT-29 cell invasiveness by modulating signaling pathways mediated by EGFR and HIF1-alpha.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	15-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117	
24692712-6	2014	Under normoxia, NS398 reduced signalling pathways induced by EGF [phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT), extracellular-signal-regulated kinases (ERKs)], while under hypoxia, EGF stimulation and NS398 treatment was associated with HIF-1alpha expression.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	16-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	250-260	
17511040-7	2007	However, all of these changes were reversed by HIF-1alpha inhibitor NS398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	68-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57	
16527254-9	2006	In addition, pretreatment with NS-398 to inhibit COX-2 activity also effectively suppressed DFX-induced HIF-1alpha accumulation in human colon cancer cells, providing the evidence that COX-2 plays as a regulator of HIF-1alpha accumulation in DFX-treated colon cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114	
16527254-9	2006	In addition, pretreatment with NS-398 to inhibit COX-2 activity also effectively suppressed DFX-induced HIF-1alpha accumulation in human colon cancer cells, providing the evidence that COX-2 plays as a regulator of HIF-1alpha accumulation in DFX-treated colon cancer cells.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	215-225	
15864753-10	2005	In addition, pretreatment with NS-398 to reduce PGE2 also effectively suppressed HIF-1alpha protein accumulation and achieved a similar inhibitory effect on VEGF production as did antisense HIF-1alpha transfection.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91	
15382039-0	2004	NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-51	
15382039-0	2004	NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-61	
15382039-6	2004	NS398 also inhibits hypoxia-induced angiogenesis, which may be mediated by the inhibition of HIF-1 function in a COX-2-dependent manner.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-98	
15382039-8	2004	On the one hand, NS398 decreases the expression of HIF-1alpha mRNA and reduces HIF-1alpha synthesis in a COX-2/PGE2 dependent way, which can be restored by addition of exogenous PGE2 that activates the phosphatidylinositol 3-kinase/AKT/p70s6k signaling pathway.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	17-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61	
15382039-11	2004	These data not only confirm the inhibitory effect of NS398 on HIF-1alpha and HIF-1 transcriptional activity but also demonstrate that such an effect occurs at multiple levels involving both COX-2 dependent and independent mechanisms.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72	
15382039-11	2004	These data not only confirm the inhibitory effect of NS398 on HIF-1alpha and HIF-1 transcriptional activity but also demonstrate that such an effect occurs at multiple levels involving both COX-2 dependent and independent mechanisms.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	53-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67