PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11755143-3 2001 The cycooxygenase-2 selective inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS-398, 1 microM) suppressed the endotoxin-induced increase of prostaglandin E(2), without significantly affecting the expression of cyclooxygenase-1 or cyclooxygenase-2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 93-99 prostaglandin-endoperoxide synthase 1 Homo sapiens 226-242 12398900-1 2002 Previous studies with both intact cells and ram seminal vesicles microsomes have shown that the specific PGHS-2 inhibitors NS-398 (N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulfonamide) and DuP-697 (5-bromo-2[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene) attenuate the inhibition of PGHS-1 caused by aspirin and indomethacin. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 123-129 prostaglandin-endoperoxide synthase 1 Homo sapiens 291-297 12398900-3 2002 Here we study the effect of NS-398 and ibuprofen, a nonspecific inhibitor, on the indomethacin-induced inhibition of purified PGHS-1 and compare this effect with that observed with microsomal enzyme. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 28-34 prostaglandin-endoperoxide synthase 1 Homo sapiens 126-132 12398900-4 2002 Dissociation constants are obtained for the interaction of NS-398 with the purified and microsomal PGHS-1 using curve fitting of experimental data on the interaction of indomethacin with the enzyme. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 59-65 prostaglandin-endoperoxide synthase 1 Homo sapiens 99-105 12398900-5 2002 The dissociation constants for ibuprofen and NS-398 for interaction with PGHS-1 are similar. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 45-51 prostaglandin-endoperoxide synthase 1 Homo sapiens 73-79 11992399-3 2002 We have shown previously that NS-398, which selectively inhibits cyclooxygenase-2 (COX-2) over cyclooxygenase-1, induces apoptosis of colorectal tumour cells and elevates COX-2 protein expression. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 30-36 prostaglandin-endoperoxide synthase 1 Homo sapiens 95-111 26151307-10 2015 NOR3 enhanced the release of prostaglandin I2 from cultured human retinal microvascular endothelial cells and the NOR3-induced prostaglandin I2 release was almost completely abolished by the cyclooxygenase-1 inhibitor SC-560, but not by the cyclooxygenase-2 inhibitor NS-398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 268-274 prostaglandin-endoperoxide synthase 1 Homo sapiens 191-207 7864817-4 1995 We have characterized the kinetic mechanisms of the interactions of purified recombinant human cyclooxygenase-1 and -2 (hCox-1, hCox-2) with the selective Cox-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulphonamide (NS-398) and some classical non-selective NSAIDs. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 225-231 prostaglandin-endoperoxide synthase 1 Homo sapiens 95-118 10477832-0 1999 PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 19-25 prostaglandin-endoperoxide synthase 1 Homo sapiens 67-73 10477832-2 1999 N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide (NS-398) and 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonyl) thiophene (DuP-697) have been shown to interact reversibly with PGHS-1, while irreversibly inhibiting PGHS-2 in a time-dependent manner. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-52 prostaglandin-endoperoxide synthase 1 Homo sapiens 178-184 10477832-8 1999 These results suggest that PGHS-2 inhibitors DuP-697 and NS-398 possibly interact with PGHS-1 at a site different from the enzyme"s catalytic site, thus causing attenuation of PGHS-1 inhibition by aspirin and indomethacin without altering PGHS-1 basal activity or the ibuprofen-induced inhibition. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 57-63 prostaglandin-endoperoxide synthase 1 Homo sapiens 87-93 10477832-8 1999 These results suggest that PGHS-2 inhibitors DuP-697 and NS-398 possibly interact with PGHS-1 at a site different from the enzyme"s catalytic site, thus causing attenuation of PGHS-1 inhibition by aspirin and indomethacin without altering PGHS-1 basal activity or the ibuprofen-induced inhibition. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 57-63 prostaglandin-endoperoxide synthase 1 Homo sapiens 176-182 10477832-8 1999 These results suggest that PGHS-2 inhibitors DuP-697 and NS-398 possibly interact with PGHS-1 at a site different from the enzyme"s catalytic site, thus causing attenuation of PGHS-1 inhibition by aspirin and indomethacin without altering PGHS-1 basal activity or the ibuprofen-induced inhibition. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 57-63 prostaglandin-endoperoxide synthase 1 Homo sapiens 176-182 9083063-5 1997 DuP697, NS-398, DFU, and SC-58125 are selective PGHS-2 inhibitors that act as time-dependent inhibitors of PGHS-2 and rapidly reversible competitive inhibitors of PGHS-1. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 8-14 prostaglandin-endoperoxide synthase 1 Homo sapiens 163-169 10219655-9 1999 NS-398 inhibited highly selective COX-2 (IC50 PGHS-1: 10.75 microM vs IC50 PGHS-2: 0.16 microM). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 prostaglandin-endoperoxide synthase 1 Homo sapiens 46-52 9022759-6 1997 In contrast, cyclooxygenase-2 mRNA was detected only at 3 h. Furthermore, most of the increased cyclooxygenase activity was immunoprecipitated with anti-cyclooxygenase-1 antibody, and was not affected by a cyclooxygenase-2-specific inhibitor, NS-398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 243-249 prostaglandin-endoperoxide synthase 1 Homo sapiens 153-169 8831731-9 1996 In contrast, the selective PGHS-2 inhibitor NS-398 exhibited time-independent inhibition of hPGHS-1 but time-dependent inhibition of hPGHS-2 in intact cells. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 44-50 prostaglandin-endoperoxide synthase 1 Homo sapiens 92-99